The influence of shielding on the biological effectiveness of accelerated particles for the induction of chromosome damage

George, K.; Cucinotta, Francis A.

doi:10.1016/j.asr.2007.01.004

Cited by 18 publications

(13 citation statements)

References 25 publications

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“…Previously we have shown that human peripheral blood lymphocyte (PBL) cells follow a linear dose response for simple exchanges following HZE particle irradiation for doses as low as 0.01 Gy, which corresponds to less than 1 in 5 particle traversal per cell for the 16 O, 28 Si, and 56 Fe particles considered [ 26 ]. CA in lymphocytes cells showed radiation quality dependence that deviated from a simple dependence on LET [ 18 ] consistent with track structure models of other endpoints (reviewed in [ 27 ]), which suggest that biological effects depend on particle charge and kinetic energy and not LET alone. In contrast to lymphocyte cells, normal human fibroblast cells have a low dose response for HZE particles that was best fit with a supra-linear dose response model, suggesting that non-targeted effect (NTE) mechanisms are at play.…”

Section: Introductionmentioning

confidence: 57%

Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints

et al. 2016

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The biological effects of high charge and energy (HZE) particle exposures are of interest in space radiation protection of astronauts and cosmonauts, and estimating secondary cancer risks for patients undergoing Hadron therapy for primary cancers. The large number of particles types and energies that makeup primary or secondary radiation in HZE particle exposures precludes tumor induction studies in animal models for all but a few particle types and energies, thus leading to the use of surrogate endpoints to investigate the details of the radiation quality dependence of relative biological effectiveness (RBE) factors. In this report we make detailed RBE predictions of the charge number and energy dependence of RBE’s using a parametric track structure model to represent experimental results for the low dose response for chromosomal exchanges in normal human lymphocyte and fibroblast cells with comparison to published data for neoplastic transformation and gene mutation. RBE’s are evaluated against acute doses of γ-rays for doses near 1 Gy. Models that assume linear or non-targeted effects at low dose are considered. Modest values of RBE (<10) are found for simple exchanges using a linear dose response model, however in the non-targeted effects model for fibroblast cells large RBE values (>10) are predicted at low doses <0.1 Gy. The radiation quality dependence of RBE’s against the effects of acute doses γ-rays found for neoplastic transformation and gene mutation studies are similar to those found for simple exchanges if a linear response is assumed at low HZE particle doses. Comparisons of the resulting model parameters to those used in the NASA radiation quality factor function are discussed.

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Section: Introductionmentioning

confidence: 57%

Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints

et al. 2016

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“…Acentric fragments often occur in conjunction with formation of dicentric chromosomes, and dicentrics are believed to occur with the same yield as translocations. The main body of work previously assessing the RBE for cytogenetic damage from HZE particle radiation has been carried out mainly using human lymphocytes as the cell system of study (5,6). It can be pointed out that such cells are radiosensitive, particularly with respect to apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…To what extent this is the case will depend on the cell system under study, in particular it will depend on the radiation sensitivity for cell killing. For the study of chromosome aberrations from HZE ions (5,6), most studies have been done with human lymphocytes, a radiation sensitive cell type with regard to apoptosis. Probably, results with lymphocytes may not be representative for more radioresistant cell types, particularly not for high LET radiations where a single hit will produce a significant, potentially cell killing dose to the cell.…”

Section: Estimation Of Risk From Highly Charged (Z) High Energy (Hze)mentioning

confidence: 99%

Relative Biological Effectiveness of High-Energy Iron Ions for Micronucleus Formation at Low Doses

2007

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“…Importantly, the data (e.g., George and Cucinotta, 2007) also show that the LET value of the RBE peak increases with Z and that RBE increases with decreasing E. As already mentioned, LET is known to provide a poor description of track structure and energy deposition in biomolecules, cells, or tissues due to the different spatial distribution of ionization and excitation events for particles that have the same LET values (as illustrated in Figure 5.4 in the 2011 NASA report using data from Plante and Cucinotta [2008]). In part, this reflects the relative contributions of delta rays for different particles of similar LET.…”

Section: Replacement Of Let-based Quality Factors With Track-structurmentioning

confidence: 99%

Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation

Nasa¹

2012

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The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Charles M. Vest is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles M. Vest are chair and vice chair, respectively, of the National Research Council.

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The influence of shielding on the biological effectiveness of accelerated particles for the induction of chromosome damage

Cited by 18 publications

References 25 publications

Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints

Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints

Relative Biological Effectiveness of High-Energy Iron Ions for Micronucleus Formation at Low Doses

Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation

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