The influence of sex on biochemical markers of bone turnover in dogs

Belić, Maja; Kušec, Vesna; Svetina, Ante; Grizelj, Juraj; Robić, Mirna; Vrbanac, Zoran; Benić, Marijan; Turk, Romana

doi:10.1016/j.rvsc.2012.01.008

Cited by 15 publications

(29 citation statements)

References 31 publications

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“…Serum crosslaps, a marker of osteoclastic activity, were measured with a human ELISA (immunodiagnostic systems Serum CrossLaps ® ELISA; Immunodiagnostic Systems GmbH, Frankfurt/Main, Germany) validated for dogs. Reference ranges for dogs found in literature using ELISAs are 0.11–1.83 ng/ml in intact female dogs (Belić et al., ). Bone alkaline phosphatase, a marker of osteoblastic activity, was measured with the human ELISA kit from MicroVue™ Quidel ® BAP Enzym‐Immunassay (TECOmedical AG, Sissach, Switzerland) validated for dogs.…”

Section: Animals Materials and Methodsmentioning

confidence: 99%

Faecal calcium excretion does not decrease during long‐term feeding of a low‐calcium diet in adult dogs

Schmitt

Mack

Kienzle

et al. 2017

Animal Physiology Nutrition

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According to a previous meta-analysis, adult dogs do not notably increase calcium absorption from the gastrointestinal tract when calcium intake is decreased. This results in a negative calcium balance even with a moderate calcium reduction. In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal requirements, and if so (ii) whether the negative calcium balance will persist for up to 6 months on a low-calcium diet. After a pre-feeding period of at least 18 weeks with calcium intake slightly exceeding maintenance requirements (200 mg/kg body weight ), 12 dogs (6 Beagles, 6 Foxhound crossbreds) were fed a low-calcium diet for 28 weeks. One dog was removed from the trial for reasons unrelated to the study at week 23. Calcium intake amounted to 60 mg/kg body weight corresponding to the minimal requirement for maintenance in dogs (NRC, 2006 (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC)). Digestion trials were carried out at week 7, 14, 21 and 28 of the low calcium feeding period. At these time points, and at week 18 of the pre-trial, blood samples were taken and analysed for calcium, ionised calcium, phosphorus, parathyroid hormone, vitamin D, serum crosslaps and bone alkaline phosphatase. Apparent calcium digestibility was negative throughout the study, suggesting a negative calcium balance. There was no systematic decrease in faecal calcium excretion. Serum calcium, ionised calcium and phosphorus remained within the reference range. Serum crosslaps increased continuously from baseline to week 28 of trial, with averages increasing from 0.102 ng/ml to 0.279 ng/ml, suggesting osteoclastic activity, indicative of calcium mobilisation from the skeleton. The study supports the theory of a lack of adaptation of intestinal calcium absorption from diets with relatively low calcium content in dogs. This agrees with clinical findings in dogs eating low-calcium diet.

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Section: Animals Materials and Methodsmentioning

confidence: 99%

Faecal calcium excretion does not decrease during long‐term feeding of a low‐calcium diet in adult dogs

Schmitt

Mack

Kienzle

et al. 2017

Animal Physiology Nutrition

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“…4 was a 25-year-old adult male and the only bull in the present study. Previous reports have described that the blood levels of bone markers may be influenced by sex in humans [ 17 ] and other animals [ 5 , 9 ]. Androgens in males have suppressive effects on osteoclastogenesis, supporting osteoblast activity [ 11 ].…”

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confidence: 99%

Serum activities of two bone markers in captive Asian elephants (<i>Elephas maximus</i>) at different ages

Hatate

Yamagishi

2018

The Journal of Veterinary Medical Science

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The blood biochemical analysis of bone markers could have a role in the early diagnosis of metabolic bone disease in animals; however, there is limited information on bone markers in captive Asian elephants (Elephas maximus). Serum samples from ten captive Asian elephants were obtained to clarify the relationship between age and the blood bone markers tartrate-resistant acid phosphatase isoform 5b (TRAP5b) and bone specific alkaline phosphatase (BALP). Serum TRAP5b and BALP activities were negatively correlated with age. A positive correlation was observed between TRAP5b activity and BALP activity. These results may contribute to the health management of captive Asian elephants.

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“…This may explain the significant increase in PINP markers OC and b-CTX in AG1 compared with other age groups. This increase is probably related to the rapid skeletal growth in this phase [5,21].…”

Section: Discussionmentioning

confidence: 93%

“…However, in individuals over 16 years, there AG3 Adults (10-15 years) was no difference between sexes [23], in accordance with the present study. In dogs, sex influenced bone markers (OC and b-CTX), which is explained by the fact that males have a more robust skeleton than females, especially during growth and puberty, when the gains in size and volume are higher [5]. Studies in humans have reported that the skeleton is influenced by sexual steroids, altering bone mineral density and, hence, the concentrations of the bone markers [18,26].…”

Section: Discussionmentioning

confidence: 99%

Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity

Imbeloni

Rahal

Filho

et al. 2015

J of Medical Primatology

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The influence of sex on biochemical markers of bone turnover in dogs

Cited by 15 publications

References 31 publications

Faecal calcium excretion does not decrease during long‐term feeding of a low‐calcium diet in adult dogs

Faecal calcium excretion does not decrease during long‐term feeding of a low‐calcium diet in adult dogs

Serum activities of two bone markers in captive Asian elephants (<i>Elephas maximus</i>) at different ages

Effect of age and sex on bone markers in Chlorocebus aethiops raised in captivity

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