The Influence of Sex Hormones on Renal Osteopontin Expression and Urinary Constituents in Experimental Urolithiasis

Yamada, Takashi; Ito, Fumio; Osaka, Yukinari; Amano, Hiroyuki; Kobayashi, Chizuko; Toma, Hiroshi

doi:10.1016/s0022-5347(05)65925-3

Cited by 76 publications

(46 citation statements)

References 16 publications

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“…Studies have reported the potential inhibitory role of female hormones in urinary stone formation. Male gender has been associated with greater number of stone episodes (16,(18)(19). Memon (22) in Saudi observed that the male to female ratio was 500:100, which is almost comparable to the present study.…”

Section: Discussionsupporting

confidence: 88%

Age at onset and clinical presentation of urolithiasis in Ajman, UAE

Venkatramana¹,

Muttappallymyalil²,

Sreedharan³

et al. 2010

AMJ

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Section: Discussionsupporting

confidence: 88%

Age at onset and clinical presentation of urolithiasis in Ajman, UAE

Venkatramana¹,

Muttappallymyalil²,

Sreedharan³

et al. 2010

AMJ

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“…vitamin C, xylitol (sweetener), or hydroxyproline (20)), mechanisms of oxalate transport in the kidney or intestine, and/or endogenous oxalate production. Studies in rats suggest that testosterone increases and estrogen decreases urinary oxalate excretion(21). A recent study in mice that lack the hepatic androgen receptor (AR) documented reduced oxalate biosynthesis (22), and that mice lacking kidney proximal or distal epithelial AR also had lower CaOx crystal formation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Demographics on Excretion of Key Urinary Factors Related to Kidney Stone Risk

Perinpam

Ware

Smith

et al. 2015

Urology

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Objective To investigate the effect of demographics including age and sex on excretion of four key urinary factors (calcium (Ca), magnesium (Mg), oxalate (Ox) and uric acid (UA)) related to kidney stone risk. Methods Twenty-four hour urine samples were collected from non-Hispanic white sibships in Rochester, MN. Height, weight, blood pressure, serum creatinine and cystatin C (CC) were measured. Diet was assessed using the Viocare food frequency questionnaire. Effects of demographics and dietary elements on urinary excretions were evaluated in univariate, multivariate, and interaction models that included age, sex, and body mass index (BMI). Results Samples were available from 709 individuals. In multivariate models, sex was a significant predictor of all four urinary factors, age was significant for all but UA excretion, and serum creatinine was significant only for Ca and Mg excretion (p<0.05). BMI or weight positively correlated with Mg, Ox and UA excretion (p<0.05). Use of a thiazide diuretic (lower) and dietary protein (higher) were associated with Ca excretion, while dietary Ca was associated with higher Mg excretion. Urinary UA excretion increased with animal protein intake and CC estimated glomerular filtration rate (eGFR), and was lower with concurrent loop diuretic use. Significant interaction effects on urinary UA excretion were observed for loop diuretic use and sex, eGFR and sex, age and animal protein intake, and BMI and eGFR (p<0.05). Conclusions Age and sex influence excretion of key urinary factors related to kidney stone risk, and should be taken into account when evaluating kidney stone patients.

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“…Alternatively, testosterone may increase the risk of NL. Indeed, many studies have demonstrated that testosterone was associated with the presence of NL [4–6]. …”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that hormonal factors play a role in the development of nephrolithiasis (NL). For instance, insulin resistance [2, 3] and testosterone [4–6] were found to be related with increased NL. Ando et al showed that insulin resistance was higher in stone formers of Japanese descent [7].…”

Section: Introductionmentioning

confidence: 99%

The relationship between insulin, insulin resistance, parathyroid hormone, cortisol, testosterone, and thyroid function tests in the presence of nephrolithiasis: a comprehensive analysis

Afsar

Karaca

2014

CEJU

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IntroductionPrevious studies have shown that hormonal factors such as levels of insulin, cortisol, testosterone, and insulin resistance are related with increased nephrolithiasis (NL). However, no previous study has evaluated the relationship between insulin, insulin resistance, thyroid hormones, cortisol, intact parathyroid hormone and testosterone levels with the presence of NL in a comprehensive manner.Materials and methodsAll patients underwent the following procedures: history taking, physical examination, biochemical analysis [including measurement of levels of insulin, thyroid hormones, cortisol, and total testosterone (for male patients only)], urine analysis, 24–hour urine collection to measure urinary protein, sodium excretion, and creatinine clearance. Insulin resistance was evaluated by the homeostasis model assessment index (HOMA–INDEX). The presence of NL was determined by ultrasonography.ResultsThe study was composed of 136 patients. In total, 30 patients had NL. Patients with NL were more likely to be older, male, obese, and smokers. Uric acid and HOMA–INDEX were also higher in patients with NL. In the whole group, only insulin (Odds ratio:1.128, CI:1.029–1.236, P:0.01) but not other hormones, and HOMA–INDEX were related with the presence of NL. In males, none of the hormones including total testosterone were associated with NL.ConclusionsOnly levels of insulin, but not other hormones were associated with the presence of NL in a group of patients with suspicion of NL. More studies are needed to highlight the mechanisms regarding NL and hormone levels.

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The Influence of Sex Hormones on Renal Osteopontin Expression and Urinary Constituents in Experimental Urolithiasis

Abstract: Testosterone appears to promote stone formation by suppressing osteopontin expression in the kidneys and increasing urinary oxalate excretion. Estrogen appears to inhibit stone formation by increasing osteopontin expression in the kidneys and decreasing urinary oxalate excretion.

Cited by 76 publications

References 16 publications

Age at onset and clinical presentation of urolithiasis in Ajman, UAE

Age at onset and clinical presentation of urolithiasis in Ajman, UAE

Effect of Demographics on Excretion of Key Urinary Factors Related to Kidney Stone Risk

The relationship between insulin, insulin resistance, parathyroid hormone, cortisol, testosterone, and thyroid function tests in the presence of nephrolithiasis: a comprehensive analysis

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