The influence of sensory experience on the glutamatergic synapse

Cooper, Daniel D.; Frenguelli, Bruno G.

doi:10.1016/j.neuropharm.2021.108620

Cited by 12 publications

(33 citation statements)

References 128 publications

(213 reference statements)

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“…RPS5KA is a downstream enzyme of BDNF that regulates gene expression and therefore may participate in the pathogenesis of depression [ 34 ]. In a recent review, the author suggested that RPS5KA might regulate key plasticity-related genes through epigenetic mechanisms to potentially avoid depression, which also supported our results [ 35 ]. As part of this neurotrophic factor cascades, MAPK signaling pathway and TNF signaling pathway might play a crucial role in immune and inflammatory response [ 36 , 37 ].…”

Section: Discussionsupporting

confidence: 87%

“…The MDD patients underwent an open-label antidepressant trial for six weeks, and their daily doses were adjusted by their clinicians based on routine clinical practice. Among these patients, 35 The average fluoxetine equivalent dose was 39.80 mg, calculated as described [24]. Additionally, participants were permitted to receive additional medication such as hypnotics and sedatives.…”

Section: Treatment and Primary Outcomementioning

confidence: 99%

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RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

Tao

Zhang

et al. 2022

BMC Psychiatry

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Objective We aimed to investigate the effect of differentially methylated genes and chronic childhood stress on the development of depressive symptoms in Chinese adolescents, as well as to test whether methylation at baseline can be used as a predictor of remission at follow-up after six weeks of treatment. Methods After recruiting 87 MDD patients and 53 healthy controls, we compared demographic and baseline clinical characteristics. The Childhood Chronic Stress Questionnaire was used to assess stress caused by early-life events. MDD patients underwent six weeks of treatment, and response to treatment was assessed using the Beck Depression Inventory-II. In addition, four MDD patients and five controls were randomly chosen for genome-wide methylation analysis. Results The gene RPS6KA5 showed significant methylation differences between the two groups. Severity of chronic childhood stress was significantly associated with increased risk of depression in adolescents, but not with treatment response. Baseline RPS6KA5 methylation can predict remission after six weeks of treatment. We did not observe any interaction between RPS6KA5 methylation and chronic childhood stress. Conclusions Our results suggest that RPS6KA5 methylation can be used as a predictor of response to treatment in adolescent MDD patients. Here we offer new evidence for the role of epigenetics in early response to treatment of depression. Trial registration ChiCTR, ChiCTR2000033402, 31/05/2020, http://www.chictr.org.cn/index.aspx

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Section: Discussionsupporting

confidence: 87%

Section: Treatment and Primary Outcomementioning

confidence: 99%

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

Tao

Zhang

et al. 2022

BMC Psychiatry

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“…This homeostatic process governs synapse sensitivity under various excitation states 53 . Synaptic scaling is regulated by a complex network of proteins and signaling pathways, including BDNF, MSK1 and Arc/Arg3.1 54,55 . BDNF activates MSK1 that in turn acts to alter expression of Arc/Arg3.1 29 .…”

Section: Microlesion and Cbd Effects On Synaptic Scaling Regulatorsmentioning

confidence: 99%

Cannabidiol Inhibits Neuroinflammatory Responses and Circuit-Associated Synaptic Loss Following Damage to a Songbird Vocal Pre-motor Cortical-Like Region

Tripson

Litwa

Soderstrom

2023

Preprint

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The non-euphorigenic phytocannabinoid cannabidiol (CBD) has been used successfully to treat childhood-onset epilepsies. These conditions are associated with developmental delays that often include vocal learning. Zebra finch song, like language, is a complex behavior learned during a sensitive period of development. Song quality is maintained through continuous sensorimotor refinement involving circuits that control learning and production. Within the vocal motor circuit, HVC is a cortical-like region that when partially lesioned temporarily disrupts song structure. We previously found CBD (10 mg/kg/day) improves post-lesion vocal recovery. The present studies were done to understand mechanisms underlying CBD vocal protection. We found CBD-improved vocal recovery is accompanied by reduced expression of inflammatory mediators and oxidative stress markers. These effects were associated with regionally-reduced expression of the microglia marker TMEM119. As microglia are key regulators of synaptic reorganization, we measured synapse densities, finding significant lesion-induced circuit-wide decreases that were largely reversed by CBD. Synaptic protection was accompanied by NRF2 activation and BDNF/ARC/ARG3.1/MSK1 expression implicating mechanisms important to song circuit node mitigation of oxidative stress and promotion of synaptic homeostasis. Our findings indicate CBD improves post-lesion recovery of a complex learned behavior through an array of neuroprotective processes consistent with modulation of multiple cell signaling systems.

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“…Modulators of plasticity are also positive and negative stressors, as well as sensorial and somatosensory experiences. Independently of the nature of regulators, neuronal plasticity in mammals is largely put into action through changes of synaptic contacts between pre-existing cells (synaptic formation, elimination and change in strength) [10]. Indeed, the hippocampus is endowed with a high degree of so-called structural plasticity [11], which influences the number of synapses and the formation of novel connections among neurons, as well as the complexity of their dendritic arborizations.…”

Section: The Endless Hippocampal Plasticitymentioning

confidence: 99%

Retinal Plasticity

Strettoi

Marco

Orsini

et al. 2022

IJMS

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Brain plasticity is a well-established concept designating the ability of central nervous system (CNS) neurons to rearrange as a result of learning, when adapting to changeable environmental conditions or else while reacting to injurious factors. As a part of the CNS, the retina has been repeatedly probed for its possible ability to respond plastically to a variably altered environment or to pathological insults. However, numerous studies support the conclusion that the retina, outside the developmental stage, is endowed with only limited plasticity, exhibiting, instead, a remarkable ability to maintain a stable architectural and functional organization. Reviewed here are representative examples of hippocampal and cortical paradigms of plasticity and of retinal structural rearrangements found in organization and circuitry following altered developmental conditions or occurrence of genetic diseases leading to neuronal degeneration. The variable rate of plastic changes found in mammalian retinal neurons in different circumstances is discussed, focusing on structural plasticity. The likely adaptive value of maintaining a low level of plasticity in an organ subserving a sensory modality that is dominant for the human species and that requires elevated fidelity is discussed.

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The influence of sensory experience on the glutamatergic synapse

Cited by 12 publications

References 128 publications

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

RPS6KA5 methylation predict response to 6-week treatment for adolescent MDD patients

Cannabidiol Inhibits Neuroinflammatory Responses and Circuit-Associated Synaptic Loss Following Damage to a Songbird Vocal Pre-motor Cortical-Like Region

Retinal Plasticity

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