The influence of selected nutritional components in lung cancer risk – unsaturated fatty acids, isothiocyanates, selenium

Zabłocka, Katarzyna; Biernat, Jadwiga

doi:10.5114/wo.2010.979

Cited by 3 publications

(2 citation statements)

References 29 publications

(41 reference statements)

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“…The protective effects of selenium in the etiology of cancer diseases result from its effect on cell membranes protecting against oxidative stress, and also from the stabilizing effect on DNA and enhancement of cellular immune response [1,87]. It has also been found that selenium inhibits tumor cell proliferation via the effect exerted on the expression of p53 tumor suppressor gene, and Bcl-2 apoptosis-suppressor gene [101]. It has been shown that in the case of cancer occurrence, lesions in the p53 gene are reported [102].…”

Section: Influence Of Selenium In Cancer Preventionmentioning

confidence: 99%

Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review

2016

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Selenium is one of the elements classified within the group of micronutrients which are necessary in trace amounts for the proper functioning of organisms. Selenium participates in the protection of cells against excess H 2 O 2 , in heavy metal detoxification, and regulation of the immune and reproductive systems as well. It also ensures the proper functioning of the thyroid gland. Selenium induces the occurrence of the selenoprotein synthesis process involved in the antioxidant defense mechanism of the organism. Recent years have brought much success in the studies on selenium. Anticarcinogenic properties of selenium against some cancers have been reported. Supplementation is increasingly becoming a solution to this problem. A large number of different supplementation methods are promoting studies in this area. Slight differences in the selenium content can result in excess or deficiency, therefore supplementation has to be done carefully and cautiously.

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Section: Influence Of Selenium In Cancer Preventionmentioning

confidence: 99%

Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review

2016

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“…Also, the protective effects of Se in the etiology of cancer result from its effect on cell membranes protecting against oxidative stress, and the stabilizing effect on DNA and increase of cellular immune response. It has been indicated that Se inhibits tumor cell proliferation via the effect exerted on Bcl-2 apoptosis suppressor gene and the expression of p53 tumor suppressor gene [ 18 , 22 ]. Protein hydrophobic interactions induced by a variety of nutritional and environmental factors can provide rational explanation for a number of pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Selenium Supplementation on Clinical Outcomes, Metabolic Profiles, and Pulsatility Index of the Uterine Artery in High-Risk Mothers in Terms of Preeclampsia Screening with Quadruple Test: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mesdaghinia

Shahin

Ghaderi

et al. 2022

Biol Trace Elem Res

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Data on the effects of selenium (Se) supplementation on clinical outcomes, metabolic profiles, and pulsatility index (PI) in high-risk mothers in terms of preeclampsia (PE) screening with quadruple tests are scarce. This study evaluated the effects of Se supplementation on clinical outcomes, metabolic profiles, and uterine artery PI on Doppler ultrasound in high-risk mothers in terms of PE screening with quad marker. The current randomized, double-blind, placebo-controlled trial was conducted among 60 high-risk pregnant women screening for PE with quad tests. Participants were randomly allocated into two groups (30 participants each group), received either 200 µg/day Se supplements (as Se amino acid chelate) or placebo from 16 to 18 weeks of pregnancy for 12 weeks. Clinical outcomes, metabolic profiles, and uterine artery PI were assessed at baseline and at the end of trial. Se supplementation resulted in a significant elevation in serum Se levels (β 22.25 µg/dl; 95% CI, 18.3, 26.1; P < 0.001) compared with the placebo. Also, Se supplementation resulted in a significant elevation in total antioxidant capacity (β 82.88 mmol/L; 95% CI, 3.03, 162.73; P = 0.04), and total glutathione (β 71.35 µmol/L; 95% CI, 5.76, 136.94; P = 0.03), and a significant reduction in high-sensitivity C-reactive protein levels (β − 1.52; 95% CI, − 2.91, − 0.14; P = 0.03) compared with the placebo. Additionally, Se supplementation significantly decreased PI of the uterine artery in Doppler ultrasound (β − 0.09; 95% CI, − 0.14, − 0.04; P = 0.04), and a significant improvement in depression (β − 5.63; 95% CI, − 6.97, − 4.28; P < 0.001), anxiety (β − 1.99; 95% CI, − 2.56, − 1.42; P < 0.001), and sleep quality (β − 1.97; 95% CI, − 2.47, − 1.46; P < 0.001). Se supplementation for 12 weeks in high-risk pregnant women in terms of PE screening with quad marker had beneficial effects on serum Se level, some metabolic profiles, uterine artery PI, and mental health. IRCT Registration: htpp:// www.irct.ir ; identifier IRCT20200608047701N1.

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Two Sides of Selenium: Occurrence and Determination of Selenium Forms in Food and Environmental Samples Using Analytical Methods

Zembrzuska

Karbowska

Gołębiewska

2021

Food Bioactive Ingredients

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The influence of selected nutritional components in lung cancer risk – unsaturated fatty acids, isothiocyanates, selenium

Cited by 3 publications

References 29 publications

Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review

Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review

The Effect of Selenium Supplementation on Clinical Outcomes, Metabolic Profiles, and Pulsatility Index of the Uterine Artery in High-Risk Mothers in Terms of Preeclampsia Screening with Quadruple Test: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Two Sides of Selenium: Occurrence and Determination of Selenium Forms in Food and Environmental Samples Using Analytical Methods

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