The influence of sample size and gender composition on the meta-analysis conclusion of platelet-rich plasma treatment for osteoarthritis

Zhao, Kun; Liu, Yan-shan; Qian, Lin-na; Nie, Nanfang; Leptihn, Sebastian; Bunpetch, Varitsara; Zou, Xiaohui; Ouyang, Hongwei

doi:10.1016/j.jot.2019.10.002

Cited by 10 publications

(10 citation statements)

References 54 publications

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“…Sex has been identified an influencing factor in PRP efficacy studies in patients with OA, as no sex subanalysis was undertaken in this analysis, it is unclear whether the same is true for FAI. 42 It is uncertain whether differences in FAI type are likely to alter the overall conclusions of the evidence, given the PRP was administered as part of the corrective surgery, and the patients were not arthritic at the time.…”

Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Is Not Associated With Improved Outcomes Following Hip Femoroacetabular Impingement Surgery: Very Low-Quality Evidence Suggests Hyaluronic Acid and Cell-Based Therapies May Be Beneficial—A Systematic Review of Biological Treatments

Mullins¹,

Filan²,

Carton

2022

Arthroscopy, Sports Medicine, and Rehabilitation

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Section: Discussionmentioning

confidence: 99%

Platelet-Rich Plasma Is Not Associated With Improved Outcomes Following Hip Femoroacetabular Impingement Surgery: Very Low-Quality Evidence Suggests Hyaluronic Acid and Cell-Based Therapies May Be Beneficial—A Systematic Review of Biological Treatments

Mullins¹,

Filan²,

Carton

2022

Arthroscopy, Sports Medicine, and Rehabilitation

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“…It was also concluded that sample size and gender composition play important role in determining the efficacy of PRP. [ 20 ] Hassan et concluded that on comparing the parameters between PRP and Arthrocentesis groups, the difference was statistically insignificant. The improvement in pain relief was better in the PRP group but the improvement in TMJ clicking was better in arthrocentesis group.…”

Section: Discussionmentioning

confidence: 99%

Minimally invasive intraarticular platelet rich plasma injection for refractory temporomandibular joint dysfunction syndrome in comparison to arthrocentesis

Chandra

Goyal

Srivastava

2021

Journal of Family Medicine and Primary Care

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Context: Internal derangements of temporomandibular joint (TMJ) with associated symptoms which do not respond to conservative therapies are refractory cases of temporomandibular joint dysfunction syndrome (TMD). Minimally invasive techniques like arthrocentesis and platelet rich plasma (PRP) injections are usually employed to improve TMJ symptoms and function in these cases. Aims: To compare PRP with arthrocentesis for evaluating the effectiveness of PRP in relieving symptoms of refractory TMJ pain dysfunction syndrome. Setting and Design: A clinical study was carried out on 52 patients of refractory Temporomandibular joint dysfunction syndrome. The patients were divided in two groups that is Group A - test group and Group B -control Group. Methods and Material: Group A consisted of 26 patients who underwent intraarticular PRP injection in TMJ and Arthrocentesis of TMJ was done in 26 patients of Group B. TMJ pain, Maximium Interincisal opening and TMJ clicking were assessed among the group as well as between the groups over a period of 6 months. Statistical Analysis Used: Repeated Measure ANOVA was used to compare the parameters within the groups and T test was used for group comparison at 0.05 level of significance. Result: There was statistically significant difference in pain intensity improvement 1 ± 0.75 versus 3.17 ± 2.13, maximum interincisal opening 39.86 ± 2.86 versus 37.59 ± 4.03 and clicking 6 versus 16 between the PRP group and arthrocentesis group at P < 0.05. Conclusions: Intraarticular PRP injection for the management of refractory TMD is more effective than arthrocentesis in reducing symptoms and functional improvement.

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“…Intra-articular drug delivery has various advantages over the systemic administration, such as increased local bioavailability throughout the joint capsule and fewer adverse events [3]. Intra-articular delivery of corticosteroids, hyaluronic acid, platelet-rich plasma and glucosamine or chondroitin can increase local bioavailability and serve as another strategy to reduce pain and relieve symptoms [3,[18][19][20][21]23]. However, synovial fluid with complex biological composition and high viscosity affects drug's properties and diffusion.…”

Section: Inadequate Clinical Therapy Efficacymentioning

confidence: 99%

Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

Dai

Guo

et al. 2021

Nano-Micro Lett.

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Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge medical and socioeconomic burdens. Intra-articular administration of agents is clinically used for pain management. However, the effectiveness is inapparent caused by the rapid clearance of agents. To overcome this issue, nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents. Given the therapeutic programs are inseparable from pathological progress of osteoarthritis, an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders. In this review, we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release. Then, we review the interactions of nanoparticles with cartilage microenvironment and the rational design. Furthermore, we highlight advances in the therapeutic schemes according to the pathology signals. Finally, armed with an updated understanding of the pathological mechanisms, we place an emphasis on the development of “smart” bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals. We anticipate that the exploration of nanoparticles by balancing the efficacy, safety, and complexity will lay down a solid foundation tangible for clinical translation.

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The influence of sample size and gender composition on the meta-analysis conclusion of platelet-rich plasma treatment for osteoarthritis

Cited by 10 publications

References 54 publications

Platelet-Rich Plasma Is Not Associated With Improved Outcomes Following Hip Femoroacetabular Impingement Surgery: Very Low-Quality Evidence Suggests Hyaluronic Acid and Cell-Based Therapies May Be Beneficial—A Systematic Review of Biological Treatments

Platelet-Rich Plasma Is Not Associated With Improved Outcomes Following Hip Femoroacetabular Impingement Surgery: Very Low-Quality Evidence Suggests Hyaluronic Acid and Cell-Based Therapies May Be Beneficial—A Systematic Review of Biological Treatments

Minimally invasive intraarticular platelet rich plasma injection for refractory temporomandibular joint dysfunction syndrome in comparison to arthrocentesis

Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy

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