The influence of retrobulbar adipose tissue volume upon intraocular pressure in obesity

Stojanov, Oliver; Stokić, Edita; Sveljo, Olivera; Naumovic, Nada

doi:10.2298/vsp1305469s

Cited by 36 publications

(38 citation statements)

References 20 publications

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“…The aetiology of the elevated IOP in obese individuals may be due to increased intra-abdominal pressure causing increased episcleral venous pressure and choroidal vascular congestion (Ece et al 2015) or increased orbital fat causing episcleral venous compression (Lam et al 2016). Stojanov et al (2013) found significantly higher mean retrobulbar adipose tissue volume in obese subjects compared to normal-weight individuals using magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 95%

Reduction of intraocular pressure after bariatric surgery

Burgansky-Eliash

Achiron

Hecht

et al. 2018

Acta Ophthalmologica

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In a cohort of obese individuals undergoing sleeve gastrectomy, there was a significant decrease in IOP measured 3-6 months after the procedure. Our results suggest that significant weight loss could have beneficial effects on IOP in obese individuals with ocular hypertension which might enable avoidance of antiglaucoma medications. The high likelihood of a reduction in IOP should be taken into account when considering bariatric surgery in such patients.

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Section: Discussionmentioning

confidence: 95%

Reduction of intraocular pressure after bariatric surgery

Burgansky-Eliash

Achiron

Hecht

et al. 2018

Acta Ophthalmologica

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“…In intraocular arteries supplying the ciliary body of the pig, NA and neuropeptide Y induced contraction that could elevate intraocular pressure, a central feature of open‐angle glaucoma (Kringelholt et al ., ). Obesity in humans, which may correlate with elevated NA signalling, is associated with both increased retrobulbar adipose tissue volume and elevated intraocular pressure (Stojanov et al ., ). A longitudinal cohort study found that hypertension was associated with (hazard ratio 1.17) increased risk of developing open‐angle glaucoma (Newman‐Casey et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Noradrenaline transmission reducing drugs may protect against a broad range of diseases.

Fitzgerald

2014

Auton Autocoid Pharmacol

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1 A growing body of evidence suggests that the signalling molecule, noradrenaline (NA), plays a pathophysiological role in a broad range of psychiatric, neurological and peripheral disorders. Both preclinical and clinical data suggest that elevated NA signalling may be involved in the aetiology of major diseases such as depression, Alzheimer's disease and diabetes mellitus. 2 The molecular pathways by which NA may cause the manifestation of disease remain poorly understood, although they may include G protein-coupled receptor modulation of the Ras/MAP kinase, Stat3 and PI3K pathways, among others. In both individual animals and humans, NA tone may be elevated largely due to genetics, but also because of the exposure to marked psychological stress or trauma, or other environmental factors. 3 As NA is involved in the 'fight or flight' response by the sympathetic nervous system, this transmitter may be elevated in a large number of organisms due to evolutionary selection of enhancing responses to immediate environmental dangers. Likewise, acetylcholine signalling by the parasympathetic ('rest and digest') nervous system may be relatively diminished. This putative autonomic imbalance may result in diminished engagement in homeostatic processes, resulting in the emergence and progression of a number of diseases throughout the body. 4 In this scenario, a large number of individuals may benefit from chronic use of pharmacological agents - such as clonidine, guanfacine, propranolol or prazosin - that diminish NA signalling throughout the body. If so, NA transmission lowering drugs may protect against a wide range of diseases.

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“…Stojanov et al . [11] showed obese subjects had significantly higher IOP than subjects with normal weight. Mori et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of oral contraceptive pills on central corneal thickness in young women

et al. 2016

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Objectives:Hormonal changes during oral contraceptive pill (OCP) use may affect central corneal thickness (CCT) values. We aimed to evaluate the impact of OCP use on CCT values in healthy young women.Materials and Methods:Fifty women subjects who use OCP for contraception (Group 1) and forty control subjects (Group 2) who do not use OCP were included in this prospective study. None of the patients had any history of systemic or ocular diseases. The CCT values measured by ultrasonic pachymeter (Nidek US-4000 Echoscan, Japan) and the intraocular pressure (IOP) values were measured by noncontact tonometer (Reichert 7 CR Corneal Response Technology, USA) at the time of admission to our clinic. The demographic findings and body mass index (BMI) scores of participants were also recorded.Results:The mean ages were 32.8 ± 5.6 for OCP + patients (Group 1) and 31.3 ± 6.9 for OCP-patients (Group 2) (P = 0.28). The mean CCT values were significantly higher in Group 1 when compared to that of the Group 2 (540.9 ± 30.4 μm and 519.6 ± 35.6 μm, respectively) (P = 0.003). The mean IOP value was 14.3 ± 2.5 mmHg in Group 1 and 14.4 ± 2.7 mmHg in Group 2 (P = 0.96). The mean BMI scores were 24.4 ± 5.8 kg/m2 in Group 1 and 24.6 ± 3.5 kg/m2 in Group 2 (P = 0.83).Conclusion:Our findings revealed that CCT values were significantly higher in patients with OCP use. Ophthalmologists should be aware of potential elevated CCT levels in these patients.

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The influence of retrobulbar adipose tissue volume upon intraocular pressure in obesity

Cited by 36 publications

References 20 publications

Reduction of intraocular pressure after bariatric surgery

Reduction of intraocular pressure after bariatric surgery

Noradrenaline transmission reducing drugs may protect against a broad range of diseases.

Impact of oral contraceptive pills on central corneal thickness in young women

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