“…Care should be taken during long-time culture that the cell number is not overestimated due to cells that might grow close to the scaffold while not being part of the final construct. Although, more frequently used in other scientific domains, such as modeling and controlling heart rate responses of athletes (Lefever et al, 2012), energy transfer in buildings (Price et al, 1999), precision life stock farming (Silva et al, 2009), and other environmental and economic phenomena (Haredasht et al, 2011;Young, 1998), the DBM modeling technique is, as far as known by the author, unexplored in the context of bioprocess control for TE bioreactors. Nevertheless this data-based approach holds promise for the TE domain since high quality bioprocess data are often available from the bioreactor system and purely mechanistic models for complicated biological processes are often non-existent or have a significant cost of development (Koutinas et al, 2012).…”