The Influence of Repetitive Transcranial Magnetic Stimulation on Sleep in Parkinson’s Disease

Antczak, Jakub; Rakowicz, Maria; Banach, Marta; Derejko, Mirosława; Sienkiewicz, J.; Zalewska, U.; Więcławska, M.; Jernajczyk, Wojciech

doi:10.1016/s0208-5216(11)70017-1

Cited by 4 publications

(7 citation statements)

References 31 publications

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“…The effects of rTMS on sleep have also been studied in Parkinson disease in two separate studies (van Dijk et al 2009;Antczak et al 2011), both of which applied HF over either the motor or parietal cortex. Both studies found improvement in sleep by subjective and objective measures.…”

Section: Effect Of Frequency and Locationmentioning

confidence: 99%

“…Both studies found improvement in sleep by subjective and objective measures. However, one of the studies found that the improvement seen on polysomnographic (PSG) studies was likely the result of improvement in nocturnal motor symptoms of Parkinson disease more than actual influence on sleep itself (Antczak et al 2011). The other study found no changes in motor symptoms, but did find improvement in actigraphic recordings if rTMS was applied to the parietal cortex (van Dijk et al 2009).…”

Section: Effect Of Frequency and Locationmentioning

confidence: 99%

“…The other study found no changes in motor symptoms, but did find improvement in actigraphic recordings if rTMS was applied to the parietal cortex (van Dijk et al 2009). These two studies used different questionnaires and measuring techniques, which could explain the conflicting results (Antczak et al 2011). The heterogenous results of these studies on sleep illustrate that rTMS's effect is complex, due to variations in rTMS settings, target brain regions, as well as the underlying neurological conditions.…”

Section: Effect Of Frequency and Locationmentioning

confidence: 99%

See 2 more Smart Citations

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Oroz

Kung

Croarkin

et al. 2021

Sleep Science Practice

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Repetitive transcranial magnetic stimulation (rTMS) is a neuromodulatory technique approved by the US Food and Drug Administration for use in treatment-resistant major depressive disorder. It works by generating localized magnetic fields that create depolarizing electrical currents in neurons a few centimeters below the scalp. This localized effect is believed to stimulate neural plasticity, activate compensatory processes, and influence cortical excitability. Additionally, rTMS has been used in a variety of clinical trials for neurological and psychiatric conditions such as anxiety, post-traumatic stress disorder and epilepsy. Beneficial effects in sleep parameters have been documented in these trials, as well as in major depressive disorder, and have led to an interest in using rTMS in the field of sleep medicine for specific disorders such as insomnia, hypersomnia, and restless legs syndrome. It is unknown whether rTMS has intrinsically beneficial properties when applied to primary sleep disorders, or if it only acts on sleep through mood disorders. This narrative review sought to examine available literature regarding the application of rTMS for sleep disorder to identify knowledge gaps and inform future study design. The literature in this area remains scarce, with few randomized clinical trials on rTMS and insomnia. Available studies have found mixed results, with some studies reporting subjective sleep improvement while objective improvement is less consistent. Due to the heterogeneity of results and the variations in rTMS protocols, no definitive conclusions have been reached, signaling the need for further research.

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Section: Effect Of Frequency and Locationmentioning

confidence: 99%

Section: Effect Of Frequency and Locationmentioning

confidence: 99%

Section: Effect Of Frequency and Locationmentioning

confidence: 99%

See 1 more Smart Citation

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Oroz

Kung

Croarkin

et al. 2021

Sleep Science Practice

View full text Add to dashboard Cite

show abstract

“…165 To date, only a few studies have delivered daytime noninvasive transcranial stimulation in patients with PD and measured the impact on sleep. [176][177][178][179][180] Despite varied methodologies and stimulation sites, these studies have shown some modest improvements in sleep latency and fragmentation, nocturnal awakenings, and subjective fatigue. Whether such approaches could have greater efficacy by directly targeting specific sleep stages overnight in PD remains unknown.…”

Section: Effects Of Noninvasive Stimulation On Sleepmentioning

confidence: 99%

“…These studies, although in the early stage, suggest noninvasive brain stimulation can alter sleep and impact memory 165 . To date, only a few studies have delivered daytime noninvasive transcranial stimulation in patients with PD and measured the impact on sleep 176‐180 . Despite varied methodologies and stimulation sites, these studies have shown some modest improvements in sleep latency and fragmentation, nocturnal awakenings, and subjective fatigue.…”

Section: Can Sleep Disturbances Seen In Pd Be Reversed?mentioning

confidence: 99%

The Neurophysiology of Sleep in Parkinson's Disease

et al. 2021

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Sleep disturbances are among the most common nonmotor complications of Parkinson's disease (PD), can present in prodromal stages, and progress with advancing disease. In addition to being a symptom of neurodegeneration, sleep disturbances may also contribute to disease progression. Currently, limited options exist to modulate sleep disturbances in PD. Studying the neurophysiological changes that affect sleep in PD at the cortical and subcortical level may yield new insights into mechanisms for reversal of sleep disruption. In this article, we review cortical and subcortical recording studies of sleep in PD with a particular focus on dissecting reported electrophysiological changes. These studies show that slow-wave sleep and rapid eye movement sleep are both notably disrupted in PD. We further explore the impact of these electrophysiological changes and discuss the potential for targeting sleep via stimulation therapy to modify PD-related motor and nonmotor symptoms.

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The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions: A systematic review

Babiloni

Bellemare

Beetz

et al. 2021

Sleep Medicine Reviews

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The Influence of Repetitive Transcranial Magnetic Stimulation on Sleep in Parkinson’s Disease

Cited by 4 publications

References 31 publications

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

Transcranial magnetic stimulation therapeutic applications on sleep and insomnia: a review

The Neurophysiology of Sleep in Parkinson's Disease

The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions: A systematic review

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