The influence of relative humidity on the strength of spray-dried products.

Yamada, Noriyuki; Hirosue, Hideharu; Abe, Eiichi

doi:10.4164/sptj.24.582

Cited by 2 publications

(1 citation statement)

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“…It is likely that the stability of GPCT is impacted by the permeability and rupture of coating film, and the hygroscopicity of auxiliary layers. Due to the compaction process, pellet coating film had certain deformation and damage [28,29], resulting in a lower drug content in GPCT compared to GP under high humidity, which was also verified under high temperature and strong light conditions. Since the excipient compressibility may directly impact the integrity and permeability of the coating film during compaction, it played a dominant role in stability of GPCT.…”

Section: Drug Degradation Rate Studiesmentioning

confidence: 93%

Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

et al. 2015

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Section: Drug Degradation Rate Studiesmentioning

confidence: 93%

Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

et al. 2015

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Effect of Punch Velocity on the Compressibility and Stress Relaxation of Particles and Granules.

Danjo

Hiramatsu

Otsuka

1998

J. Soc. Powder Technolo, Japan

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Effect of punch velocity on compaction properties of particles and granules has been studied through compressibility, stress relaxation and elastic recovery. The compressibility of powders was evaluated by the modified Kawakita equation (K). The relationship between compression stress (P) and reciprocal of porosity (1/e) showed an inflection point. Denoting the slope of low compression stress in the stage of densiflcation by powder slippage and rearrangement by K1, and K2 the slope of high compression stress in the stage of elastic, plastic deformation and brittle fracture of particles and granules, the values of K1 and K2 decreased with increasing punch velocity. The diametral tensile strength had a tendency to decrease with decreasing K2, while stress relaxation increased with increasing punch velocity. In particular, constant a and b values in a cellulose system (microcrystalline cellulose) were greater than those in a non -cellulose system (a and b lactoses). As found in the relationship between constant a, b and constant K2, materials which undergo plastic deformation and fragmentation have high stress relaxation. It was also found that elastic recovery ratios of tablets increased with increasing punch velocity. Therefore punch velocity affects both the stress relaxation and elastic recovery ratio of tablets.

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The influence of relative humidity on the strength of spray-dried products.

Cited by 2 publications

References 0 publications

Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

Effect of Punch Velocity on the Compressibility and Stress Relaxation of Particles and Granules.

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