The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers

García-Ibáñez, Paula; Rosés, Carles; Agudelo, Agatha; Milagro, Fermı́n I.; Barceló, Ana M; Viadel, Blanca; Nieto, Juan Antonio; Moreno, Diego A.; Carvajal, Micaela

doi:10.3390/foods10051038

Cited by 19 publications

(19 citation statements)

References 94 publications

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“…In this sense, membrane vesicles from broccoli plants were characterized for their capacity to cross the stratum corneum [37], which is an essential requirement for the transdermal application of a drug. Lastly, oral delivery is usually not an effective route due to product degradation in the gastrointestinal tract, but recently, Garcia-Ibañez et al [42] showed that bioactive compounds encapsulated in membrane vesicles from cauliflower were able to exert their specific function after gastrointestinal digestion [42]. Hence, the oral route could also be considered to treat certain pathologies.…”

Section: Discussionmentioning

confidence: 99%

“…Considering membrane vesicles, plants are a suitable source of this type of nanocarriers. Our previous studies revealed the advantages of membrane vesicles from plants, specifically from the Brassicaceae family, and their suitable use in different biotechnological applications for agriculture [40,41], or those related to the cosmeceutical [36,37] or nutraceutical [42] industries. These vesicles are thermodynamically stable [43] and, among other reasons, this stability was associated with aquaporins [31], which are intrinsic membrane proteins that are also related to the ability of membrane vesicles to stabilize compounds, such as the glucosinolate GRA [33].…”

Section: Introductionmentioning

confidence: 99%

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Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model

Yepes-Molina

Pérez-Jiménez

Martínez‐Esparza

et al. 2022

IJMS

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At present, there is a growing interest in finding new non-toxic anti-inflammatory drugs to treat inflammation, which is a key pathology in the development of several diseases with considerable mortality. Sulforaphane (SFN), a bioactive compound derived from Brassica plants, was shown to be promising due to its anti-inflammatory properties and great potential, though its actual clinical use is limited due to its poor stability and bioavailability. In this sense, the use of nanocarriers could solve stability-related problems. In the current study, sulforaphane loaded into membrane vesicles derived from broccoli plants was studied to determine the anti-inflammatory potential in a human-macrophage-like in vitro cell model under both normal and inflammatory conditions. On the one hand, the release of SFN from membrane vesicles was modeled in vitro, and two release phases were stabilized, one faster and the other slower due to the interaction between SFN and membrane proteins, such as aquaporins. Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-α, IL-1β and IL-6, was observed. Furthermore, these results also showed that membrane vesicles by themselves had anti-inflammatory properties, opening the possibility of new lines of research to study these vesicles, not only as carriers but also as active compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model

Yepes-Molina

Pérez-Jiménez

Martínez‐Esparza

et al. 2022

IJMS

Self Cite

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“…italica ) and cabbage ( Brassica oleracea — Capitata Group ). These kinds of vegetables are rich in vitamins and fiber, and can promote intestinal peristalsis and improve inflammation; they also contain glucosinolates, substances in the body after digestion that can enhance immune function and improve the balance of intestinal flora [ 7 , 8 ]. Asparagus ( Asparagus officinalis ) is also rich in dietary fiber and oligosaccharides; some of its active ingredients such as quercetin and rutin can affect the composition of colon microbes and play a certain role in reducing intestinal inflammation and injury [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Zou

Zhang

et al. 2021

Foods

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As the largest immune organ of the human body, the intestine also plays a vital role in nutrient digestion and absorption. Some vegetables are considered to have improvement effects on the intestine. This experiment explored the effects of freeze-dried asparagus, broccoli and cabbage powder on the intestinal immune homeostasis and microflora of mice. Thirty-two mice were divided into four groups (n = 8), including control group (fed normal diet), asparagus group (fed normal diet with 5% asparagus power), broccoli group (fed normal diet with 5% broccoli power) and cabbage group (fed normal diet with 5% cabbage power). The experiment lasted 21 days. The results showed that the serum immunoglobulin concentration (IgA and IgM) and intestinal cytokine content (like IFN-γ and TNF-α) were increased after vegetable powder supplement. The experiment also detected that vegetable powder supplementation changed intestinal flora and their metabolites (short-chain fatty acid), which showed that the abundance of Lachnospiraceae and Bacteroides were decreased, while the abundance of Firmicutes and Lactobacillus as well as propionic acid and butyric acid contents were increased. Together, these vegetable powders, especially cabbage, changed the intestinal immune response and microbial activity of mice.

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“…Better stability was achieved in the presence of MD, at an inlet temperature of 170 • , and a linear degradation kinetic profile [123]. Moreover, nanoencapsulation methods were applied to obtain formulations with improved in vivo sulforaphane oral bioavailability [124,125]. By applying a melt emulsification ultrasonication technique, sulforaphane-loaded nanostructured lipid carriers (SFN-NLC) were obtained.…”

Section: Technological Strategies To Improve Stability and Bioefficac...mentioning

confidence: 99%

The Role of Glucosinolates from Cruciferous Vegetables (Brassicaceae) in Gastrointestinal Cancers: From Prevention to Therapeutics

et al. 2022

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The gastrointestinal (GI) tract is composed of rapidly renewing cells, which increase the likelihood of cancer. Colorectal cancer is one of the most frequently diagnosed GI cancers and currently stands in second place regarding cancer-related mortality. Unfortunately, the treatment of GI is limited, and few developments have occurred in the field over the years. With this in mind, new therapeutic strategies involving biologically active phytocompounds are being evaluated as anti-cancer agents. Vegetables such as broccoli, brussels sprouts, cabbage, cauliflower, and radish, all belonging to the Brassicaceae family, are high in dietary fibre, minerals, vitamins, carotenoids, polyphenols, and glucosinolates. The latter compound is a secondary metabolite characteristic of this family and, when biologically active, has demonstrated anti-cancer properties. This article reviews the literature regarding the potential of Cruciferous vegetables in the prevention and/or treatment of GI cancers and the relevance of appropriate compound formulations for improving the stability and bioaccessibility of the major Cruciferous compounds, with a particular focus on glucosinolates.

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The Influence of Red Cabbage Extract Nanoencapsulated with Brassica Plasma Membrane Vesicles on the Gut Microbiome of Obese Volunteers

Cited by 19 publications

References 94 publications

Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model

Membrane Vesicles for Nanoencapsulated Sulforaphane Increased Their Anti-Inflammatory Role on an In Vitro Human Macrophage Model

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

The Role of Glucosinolates from Cruciferous Vegetables (Brassicaceae) in Gastrointestinal Cancers: From Prevention to Therapeutics

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