The Influence of PVP Polymer Topology on the Liquid Crystalline Order of Itraconazole in Binary Systems
Luiza Orszulak,
Taoufik Lamrani,
Roksana Bernat
et al.
Abstract:This study presents a novel approach by utilizing poly-(vinylpyrrolidone)s (PVPs) with various topologies as potential matrices for the liquid crystalline (LC) active pharmaceutical ingredient itraconazole (ITZ). We examined amorphous solid dispersions (ASDs) composed of ITZ and (i) self-synthesized linear PVP, (ii) self-synthesized star-shaped PVP, and (iii) commercial linear PVP K30. Differential scanning calorimetry, X-ray diffraction, and broad-band dielectric spectroscopy were employed to get a comprehens… Show more
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