The influence of protein restriction during mid- to late gestation on beef offspring growth, carcass characteristic and meat quality

Maresca, Sebastian; Valiente, Sebastián López; Rodríguez, A. M.; Testa, Laura M.; Long, N. M.; Quintans, G.; Paván, E.

doi:10.1016/j.meatsci.2019.03.014

Cited by 36 publications

(21 citation statements)

References 24 publications

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“…Do mesmo modo, Wilson et al (2015) não obtiveram diferenças no desempenho e consumo de matéria seca de novilhos nascidos de vacas suplementadas ou não durante a gestação. Trabalhando com baixo e alto nível proteico no final da gestação, Maresca et al (2019) não observaram mudanças no consumo de alimento, ganho de peso e eficiência alimentar da progênie quando estes foram confinados.…”

Section: Implicações No Desempenho Da Progênieunclassified

Programação fetal e as consequências no desenvolvimento da progênie – uma revisão

Klein

Adams

Filho

et al. 2021

RSD

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O objetivo deste trabalho foi, através de uma revisão de literatura, identificar as principais alterações fisiológicas e comportamentais causadas pela programação fetal que afetam a saúde e o desempenho da progênie na vida pós-natal. Dentre os inúmeros fatores que alteram a formação fetal, a nutrição materna na gestação tem sido fortemente referenciada nas pesquisas recentes. A nutrição materna na gestação pode alterar de inúmeras formas a formação fetal, de forma que o feto se adapte o mais rapidamente possível ao ambiente uterino, sendo essas mudanças perceptíveis durante a vida adulta da progênie. De modo geral, a literatura sugere que a restrição materna na gestação pode promover mudanças fisiológicas e funcionais nos órgãos e tecidos do feto, preparando o organismo para sobreviver em ambientes desafiadores também na vida pós-natal. Além disso, indivíduos que experimentaram ambientes restritos durante a formação fetal, apresentam maior procura por alimento e comportamentos psicossociais alterados, tais como reações de medo, isolamento e reatividade. A maior eficiência produtiva e consequentemente menor idade de abate da progênie tem sido associada a melhor nutrição materna durante a gestação, uma vez que esses indivíduos possuem formação fetal adequada e, portanto, maior capacidade metabólica dos nutrientes em sistemas intensivos de produção que almejam o máximo desempenho animal.

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Section: Implicações No Desempenho Da Progênieunclassified

Programação fetal e as consequências no desenvolvimento da progênie – uma revisão

Klein

Adams

Filho

et al. 2021

RSD

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“…IUGR alters the proliferation and differentiation of myoblasts prepared from near-term sheep fetuses [ 14 ] and the proportion of type I (oxidative) and II (glycolytic) myofibers, the two major matured muscle cell types in the skeletal muscle tissue [ 15 , 16 , 17 ]. Fetal muscle growth impairment in meat animals can affect livestock production, especially meat quality parameters such as beef tenderness [ 18 , 19 ]. The intramuscular triglyceride content is upregulated in the nutrition-restricted fetal skeletal muscles [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal Undernutrition during Pregnancy Alters Amino Acid Metabolism and Gene Expression Associated with Energy Metabolism and Angiogenesis in Fetal Calf Muscle

et al. 2021

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To elucidate the mechanisms underlying maternal undernutrition (MUN)-induced fetal skeletal muscle growth impairment in cattle, the longissimus thoracis muscle of Japanese Black fetal calves at 8.5 months in utero was analyzed by an integrative approach with metabolomics and transcriptomics. The pregnant cows were fed on 60% (low-nutrition, LN) or 120% (high-nutrition, HN) of their overall nutritional requirement during gestation. MUN markedly decreased the bodyweight and muscle weight of the fetus. The levels of amino acids (AAs) and arginine-related metabolites including glutamine, GABA, and putrescine were higher in the LN group than those in the HN group. Metabolite set enrichment analysis revealed that the highly different metabolites were associated with the metabolic pathways of pyrimidine, glutathione, and AAs such as arginine and glutamate, suggesting that MUN resulted in AA accumulation rather than protein accumulation. The mRNA expression levels of energy metabolism-associated genes, such as PRKAA1, ANGPTL4, APLNR, CPT1B, NOS2, NOS3, UCP2, and glycolytic genes were lower in the LN group than in the HN group. The gene ontology/pathway analysis revealed that the downregulated genes in the LN group were associated with glucose metabolism, angiogenesis, HIF-1 signaling, PI3K-Akt signaling, pentose phosphate, and insulin signaling pathways. Thus, MUN altered the levels of AAs and expression of genes associated with energy expenditure, glucose homeostasis, and angiogenesis in the fetal muscle.

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“…Maternal undernutrition often impedes fetal and postnatal growth in humans [ 13 ] and cattle [ 14 ], where ruminants experience impaired skeletal muscle development and a predisposition to fat accumulation [ 15 ], ultimately impacting meat quality [ 16 ]. It is unknown whether the development of the fetal gut microbiome, whose inoculation has been widely demonstrated to begin in utero [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ], is similarly impacted by maternal diet.…”

Section: Introductionmentioning

confidence: 99%

Late Gestation Maternal Feed Restriction Decreases Microbial Diversity of the Placenta While Mineral Supplementation Improves Richness of the Fetal Gut Microbiome in Cattle

Hummel

Woodruff

Austin

et al. 2021

Animals

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Feed intake restriction impacts both humans and ruminants in late gestation, although it is unknown whether this adverse maternal environment influences the microbiome of the reproductive tract, and through it, the colonization of the fetal gut. A 2 × 2 factorial design including a 70% feed intake restriction (feed restricted ‘FR’ or control diets ‘CON’) and mineral supplementation (unsupplemented ‘S−’ or supplemented ‘S+’) was used to analyze these effects in multiparous cows (n = 27). Vaginal swabs were obtained 60, 30, and 10 days prior to the estimated calving date, along with neonatal rumen fluid and meconium. Placental tissues and efficiency measurements were collected. Microbial DNA was extracted for 16S sequencing of the V4 region. Feed restriction decreased the diversity of the placental microbiome, but not the vagina, while mineral supplementation had little impact on these microbial communities. Mineral supplementation did improve the richness and diversity of the fetal gut microbiomes in relation to reproductive microbes. These differences within the placental microbiome may influence individual health and performance. Adequate maternal nutrition and supplementation yielded the greatest placental efficiency, which may aid in the establishment of a healthy placental microbiome and fetal microbial colonization.

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The influence of protein restriction during mid- to late gestation on beef offspring growth, carcass characteristic and meat quality

Cited by 36 publications

References 24 publications

Programação fetal e as consequências no desenvolvimento da progênie – uma revisão

Programação fetal e as consequências no desenvolvimento da progênie – uma revisão

Maternal Undernutrition during Pregnancy Alters Amino Acid Metabolism and Gene Expression Associated with Energy Metabolism and Angiogenesis in Fetal Calf Muscle

Late Gestation Maternal Feed Restriction Decreases Microbial Diversity of the Placenta While Mineral Supplementation Improves Richness of the Fetal Gut Microbiome in Cattle

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