The Influence of Propionibacterium acnes (Corynebacterium parvum) Fractions on Immune Response in vivo

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

“…avidum, P. granulosum, P. acnes) have shown to be beneficial in the treatment of neoplastic and infectious diseases [163][164][165]. Besides, dead Propionibacterium acnes or a polysaccharide extracted from its cell wall have proven to be effective in the induction of macrophages with an antitumor effect [166] and in modulating an experimental immunization against…”

Clinical use of immunomodulatory agents

“…Neupogen (G-CSF) (Amgen Inc., Thousand Oaks, California, USA) Proliferation and differentiation of granulocyte progenitor cells Neutropenia due to sepsis, endotoxaemia and drug-induced myeloid hypoplasia interferon production and natural killer cytotoxicity (Lichtenstein et al 1982;Cox 1988;Kim et al 1997). In addition, administration of P acnes increases the total mass of reticuloendothelial cells and provides protection against lethal bacterial and viral challenge (Cioffi and Herbert 1985;Panangala et al 1986;Cox 1988;Weiss et al 1990;Mara et al 1994). Stimulation of systemic immunity can be documented in laboratory animals for 4 or 5 days after i.v.…”

Systemic toxicity of non-cell corynebacterium parvum (CP) in monkeys

“…Evidence indicates that some fractions of CP have similar effects as CP (Mára et al, 1994), which means that reconstruction of CP can retain its biological functions, and reducing its adverse effects by this way may be feasible. Non-cell corynebacterium parvum product (NCPP) is prepared by breaking CP using nanometer technique.…”