The Influence of Progesterone, Relaxin and Estrogen on Some Structural and Functional Changes in the Pre-Parturient Mouse

Steinetz, Bernard G.; Beach, V. L.; Kroc, Robert L.

doi:10.1210/endo-61-3-271

Cited by 44 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The separation of the pubic bones attributable to resorption of their articular surfaces, to swelling of the cartilaginous matrix, and/or transformation of the cartilage into an interpubic ligament, such as the one described in the mouse [Crelin, 1954;Crelin and Haines, 1955;Storey, 1957;Steinetz et al, 1957Steinetz et al, , 1965 and guinea pig [Ruth, 1936[Ruth, , 1937Talmage, 1947], was not observed in the rat, neither in the present study nor in the article by Crelin and Brightman [1957], who reported that the interpubic histoarchitecture in the rat was unaltered by castration, pregnancy or injections of estradiol benzoate and relaxin.…”

Section: Discussioncontrasting

confidence: 68%

Morphological Characteristics of the Interpubic Joint <i>(Symphysis pubica)</i> of Rats, Guinea Pigs and Mice in Different Physiological Situations

Ortega

Muñoz-de-Toro

Luque

et al. 2003

Cells Tissues Organs

View full text Add to dashboard Cite

The pubic joint of male and female rats, guinea pigs and mice was studied using the Picrosirius polarization method which selectively discloses the fibers of the collagenous system. Besides that, considerations were made regarding joint classification. In adult rats (both males and females, including intrapartum specimens), our results confirm those of earlier studies showing that the interpubic joint contains a central core of hyaline cartilage surrounded by fibrocartilaginous areas. Thus, in rats, the pubic joint should more properly be classified as a true synchondrosis. In virgin female guinea pigs and mice, the interpubic joint is formed of fibrocartilage (a true symphysis); whereas at term the bones are joined by a connective ligament, constituting a syndesmosis. Male mice have a similar (fibrocartilaginous) joint structure to virgin female mice, whereas male guinea pigs (like rats) have a hyaline cartilage joint. The foregoing observations indicate that the classification of the pubic joint depends upon the species, age, sex, and physiological reproductive stage studied. Species that are very similar in most other aspects (such as rats and mice) displayed different morphological features of the pubic joint to support the same reproductive processes. Together, the data reported here suggest that interspecies differences are likely to be found in other parameters and should be considered when choosing an appropriate animal model for research or teaching purposes.

show abstract

Section: Discussioncontrasting

confidence: 68%

Morphological Characteristics of the Interpubic Joint <i>(Symphysis pubica)</i> of Rats, Guinea Pigs and Mice in Different Physiological Situations

Ortega

Muñoz-de-Toro

Luque

et al. 2003

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…11). Steinetz, Beach & Kroc (1957) have recently investigated the changes in symphysis and cervix (by de Vaal's method) simultaneously in mice and confirmed this coincidence in time relations directly. Both changes start at a time which coincides approximately with the time when the foetal circulation begins to develop and increase progressively to the end of pregnancy.…”

Section: The Non-pregnant Cervixmentioning

confidence: 69%

Changes in the physical properties of the uterine cervix of the rat during pregnancy

Harkness¹,

Harkness²

1959

The Journal of Physiology

169

View full text Add to dashboard Cite

“…Preceding parturition, the mouse pubic symphysis rapidly resumes its earlier appearance and dimension, which are quite similar to those of the pubic symphysis in nulliparous mice with the dynamic involution of the interpubic ligament (Hall 1947;Crelin 1954;Storey 1957;Kroc et al 1958;Steinetz et al 1957;Horn 1960). Five days after parturition, the large fibroblasts revert back to their original chondrocyte stage (Crelin 1969).…”

Section: Introductionmentioning

confidence: 70%

“…This separation is attributed to three factors: (a) a progressive reabsorption of the symphyseal surfaces of the pubic bones; (b) the swelling of the cartilaginous matrix; and (c) the formation of a fibrous interpubic ligament. At parturition, this ligament undergoes a rapid and pronounced swelling which will transform it into a flaccid structure with a maximum length of 6 mm in mice (Hall 1947;Crelin 1954;Storey 1957;Kroc et al 1958;Steinetz et al 1957;Horn 1960).…”

Section: Introductionmentioning

confidence: 99%

Phenotypic modulation of fibroblastic cells in mice pubic symphysis during pregnancy, partum and postpartum

Moraes

Pinheiro

Toledo

et al. 2004

Cell and Tissue Research

View full text Add to dashboard Cite

In many species, the cartilaginous pubic symphysis of the pregnant female is gradually replaced by a fibrous connective tissue, forming a flexible and elastic interpubic ligament. This newly formed ligament is responsible for the separation of the pubic bones, enabling safe delivery of the young. Following labor, the ligament undergoes rapid involution. To our knowledge, no previous work has focused on the phenotypic modulation that is responsible for the changes present at the interpubic ligament throughout the relaxation and closing of the symphysis. The purpose of this study was to investigate the ultrastructural features and immunophenotype of the peculiar cell type found in the pubic symphysis of cycling, pregnant and postpartum mice. In particular, immunohistochemistry studies were conducted on the expressions of the cytoskeletal proteins desmin, vimentin and alpha-smooth muscle actin (alpha-SMA). During pregnancy, the pubic symphysis cells always expressed alpha-SMA, whereas the expression of vimentin and desmin was transient from early pregnancy to postpartum. Furthermore, the expression patterns of these three cytoskeletal proteins were distinct. Cells present in the medial region of the mouse symphysis in cycling and at D12 displayed ultrastructural features characteristic of a typical fibroblast. In contrast, during the last week of pregnancy and in postpartum these cells acquired ultrastructural features representative of a myofibroblast; for example, a fibronexus and a contractile apparatus were found to be present lying in close contact with the extracellular collagenous and elastic system fibrils. Taken together, these results strongly suggest a contractile function for these cells which might contribute to support of the varying mechanical stresses present during pubic bone movement.

show abstract

The Influence of Progesterone, Relaxin and Estrogen on Some Structural and Functional Changes in the Pre-Parturient Mouse

Cited by 44 publications

References 0 publications

Morphological Characteristics of the Interpubic Joint <i>(Symphysis pubica)</i> of Rats, Guinea Pigs and Mice in Different Physiological Situations

Morphological Characteristics of the Interpubic Joint <i>(Symphysis pubica)</i> of Rats, Guinea Pigs and Mice in Different Physiological Situations

Changes in the physical properties of the uterine cervix of the rat during pregnancy

Phenotypic modulation of fibroblastic cells in mice pubic symphysis during pregnancy, partum and postpartum

Contact Info

Product

Resources

About