The influence of probable rapid eye movement sleep behavior disorder and sleep insufficiency on fall risk in a community-dwelling elderly population

Abstract

Background The objective was to investigate the individual effect and potential interactions of probable rapid eye movement sleep behavior disorder (pRBD) and sleep insufficiency on fall risk among a Chinese elderly population. Methods Community-dwelling population aged 55 years or above were recruited from the Beijing Longitudinal Study on Aging II cohort from 2010 to 2011. Odds ratio (ORs) and 95% confidence intervals (CIs) were estimated using multivariate logistic regression models. Multiplicative and additive interactions between pRBD and sleep insufficiency were examined using likelihood ratio tests and relative excess risk due to interaction (RERI), respectively. Results Among 6891 included participants, 479 experienced at least once fall. pRBD and sleep insufficiency were both independently associated with elevated fall risk. Compared to the elderly without pRBD or sleep insufficiency, pRBD and sleep insufficiency was each associated with a 2.57-fold (OR = 2.57, 95%CI: 1.46–4.31) and 1.45-fold (OR = 1.45, 95%CI: 1.11–1.88) risk of falls individually, while their coexistence was associated with a less-than-additive 17% (OR = 1.17, 95%CI: 0.43–2.63) increased risk of falls. The combination of these two factors demonstrated evidence of a negative interaction on both multiplicative (ratio of ORs = 0.31, 95%CI: 0.10, 0.86) and additive (RERI = − 1.85, 95%CI: − 3.61, − 0.09) scale. Conclusions Our study has provided robust evidence for the adverse effect of pRBD and sleep insufficiency, as well as their negative interaction on increasing fall risk in a Chinese elderly population.

Falls and associated risk factors in a sample of old age population in Egyptian community

“…They also reflect a low physical fitness leading to inability to prevent falling in case of stumbling or losing equilibrium. Similar associations between old age persons' falls and poor vision or hearing impairment ( 16 , 17 ), sleep disorders ( 18 ), depression ( 19 ), and impaired recall and mental abilities ( 20 ) were previously reported.…”

Secular Trends in Sleep Conditions in Chinese Elderly Individuals: A National Population-Based Study

“…Meanwhile, the plan reminds us that short sleep duration is associated with an increased risk of cardiovascular disease, depression, diabetes and obesity. 6 A large amount of evidence has also suggested that short sleep duration or insomnia is significantly associated with adverse health outcomes including stroke, 7 hypertension, 8 diabetes and diabetes-related complications, 9 metabolic syndrome, 10 , 11 dyslipidemia, 12 cardiometabolic disease, 13 neoplasms, 14 , 15 fall risk, 16 depression, 17 premature death, 18 and mental disorders that are susceptible to elderly individuals, including dementia, 19 , 20 Alzheimer’s disease, 21 and cognitive decline. 22 In addition to short sleep duration, many reports of long sleep duration are concerning as long sleep has been linked with a number of adverse health outcomes including mortality, diabetes mellitus, cardiovascular disease, stroke, coronary heart disease, and obesity.…”

Gender-Specific Association Between Nighttime Sleep Duration and Falls Among Community-Dwelling Middle-Aged and Older Adults in China

“…Although the mechanisms have not been thoroughly elucidated, plausible reasons were proposed in prior studies. Han et al (2021) demonstrated that probable rapid eye movement sleep behavior disorder can interact antagonistically with sleep insufficiency in additive and multiplicative scales to influence fall risk. Racial diversity is another worth noting risk factor for association with falls.…”