The influence of potassium concentration on epileptic seizures in a coupled neuronal model in the hippocampus

Abstract

Experiments on hippocampal slices have recorded that a novel pattern of epileptic seizures with alternating excitatory and inhibitory activities in the CA1 region can be induced by an elevated potassium ion (K ? ) concentration in the extracellular space between neurons and astrocytes (ECS-NA). To explore the intrinsic effects of the factors (such as glial K ? uptake, Na ? lateral diffusion leads to epileptic seizure in neurons only when the synaptic conductance values of the excitatory and inhibitory neurons are within an appropriate range. Finally, we propose an energy factor to measure the metabolic demand during neuron firing, and the results show that different energy demands for the normal discharges and the pathological epileptic seizures of the coupled neurons.

Morphological and functional alterations of astrocytes responding to traumatic brain injury

“…K + efflux is associated with excessive neuronal activity, and K + in extracellular space is consequently moved into astrocytes by active transport that mediates local uptake to buffer extracellular K + . This process is enhanced by the Kir4.1 channel in a VGLUT1-dependent manner (Cai et al, 2011), the Na + -K + -Cl − -cotransporter-1 (NKCC1) (Amadeo et al, 2018), the Na + -K + -ATPase pump (Du et al, 2016) and Cx43 (Lykke et al, 2017). The molecular mechanism of maintaining Cl − ion homeostasis by astrocytes includes GABA receptor anion channels (Fraser et al, 1995) and ClC-2.…”

The Energy Coding of a Structural Neural Network Based on the Hodgkin–Huxley Model

“…This coding theory has made several research findings possible (Wang et al, 2006 , 2008 , 2016 , 2017 ; Wang and Wang, 2014 ; Wang R. et al, 2014 ; Wang Z. et al, 2014 ; Du et al, 2016 ; Wang and Zhu, 2016 ; Yan et al, 2016 ; Zheng et al, 2016 ). Previously, Wang and Zhang proposed a novel biophysical model of neurons, which provides the membrane potential function of a single neuron and the corresponding energy function with their calculation method (Wang et al, 2006 ).…”

Down-regulated expression of aquaporin-4 in the cerebellum after status epilepticus

“…Epilepsy is a common and severe neurological disorder that can undermine the psychological health and quality of life of patients (Ngugi et al 2010;Rowley and Patel 2013;Du et al 2016). Temporal lobe epilepsy (TLE) is the most common form and is usually preceded by prolonged seizures or SE.…”