The influence of polyelectrolyte charges of polyurethane membrane surface on the growth of human endothelial cells

Zhu, Yabin; Sun, Yu

doi:10.1016/j.colsurfb.2004.04.008

Cited by 33 publications

(22 citation statements)

References 19 publications

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“…Several evidences support that net charge of biomaterials or chemical surfaces influence the growth and specific responses of different cellular types . In our experiments, sponges built with CS ALG that bore charge ratios n + /n − 1.5 and 1.9 showed the highest cellular proliferation levels, particularly the material with charge ratio n + /n − 1.9, suggesting that an adequate polymer concentration generates an electrical charge balance favorable to cellular growth.…”

Section: Discussionsupporting

confidence: 69%

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

Orellana

Giacaman

Pavicic

et al. 2016

J Biomedical Materials Res

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The study of biomaterials by electrical charge scaling to explore the role of net charge on biocompatibility and suitability for tissue regeneration has been limited as has the search for products that could improve this first-rate variable. In the present study, we prepared sponges composed of chitosan/alginate (CS/ALG) with or without hyaluronic acid (HA) by mixing polymer stock solutions of different net electric charge ratios (n(+/) n(-) ), and then lyophilizing them to obtain porous materials. The electric charge ratios n(+/) n(-) studied were 0.3, 0.8, 1.0, and 2.5 for CS/ALG and 0.3, 1.0, 1.9, and 3.7 for CS/ALG/HA sponges. Under these conditions a role for net electric charge balance over sponge microstructure rearrangement, protection to dissolution, cellular proliferation, and cell-cell interactions was apparent, effects that were enhanced by copolymer modification with HA. Mass balance, electric charge, and specific products that influence both such as HA, have a potential in biomaterials for wound healing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2537-2543, 2016.

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Section: Discussionsupporting

confidence: 69%

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

Orellana

Giacaman

Pavicic

et al. 2016

J Biomedical Materials Res

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“…Polyurethanes have an established record of biocompatibility [15,16], the ability to be functionalised to improve cell growth and proliferation [16][17][18][19][20], and controllable degradation kinetics [21]. Additionally, the mechanical properties of polyurethanes can be tailored for uses as hard [22][23][24] and soft tissue [25][26][27][28] biomaterials.…”

Section: Introductionmentioning

confidence: 98%

Synthesis of two-component injectable polyurethanes for bone tissue engineering

Bonzani

Adhikari²,

Houshyar³

et al. 2007

Biomaterials

153

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“…Cell adhesive molecules such as fibronectin, vitronectin, or laminin reportedly play an important role in the attachment of cells to substrate. According Zhu and Sun,34 before endothelial cells attach to the matrix, they must recognize the specific conformation of the adsorbed proteins in the culture medium, but a negative surface repulsed the adsorption of proteins and thus blocked the anchorage of the negative HUVECs to the surface. Comparing with the result discussed under the Hemocompatibility of Autoxidized DLPE Films section for protein absorption, higher amounts of albumin, a negatively charged carboxylic acid‐rich protein, adsorbed on the autoxidized DLPE films than the glass control (Figure 7), implied a possibly positive charge, or at least not negative charge on the surfaces.…”

Section: Resultsmentioning

confidence: 99%

Film from peroxidation of an amino phospholipid and its biocompatibility

Wang¹,

Liu²,

Ji³

et al. 2006

J Biomed Mater Res

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A new kind of phospholipid product with fluorescence was derived from autoxidation of an aminophospholipid, L-alpha-phosphatidylethanolamine dilinoleoyl in solid film state. Atomic force microscopy showed that the film product was composed of round and elliptical vesicles with diameters of about 20-45 nm. The product was difficult to dissolve in water and most organic solvents. Fourier transform infrared spectroscopy, solid-state (13)C NMR, and solid-state (31)P NMR indicated that the unsaturated double carbon bond decreased with the reaction, and polymerization within/between phospholipid molecules occurred. Endothelial cells from human vein seeded onto the film showed the highest proliferating activity compared with seeding onto Corning culture plate, glass plate, or phospholipid film with phosphorylcholine head group, as evaluated by 3-(4,5-timethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (p < 0.001). The hemocompatibility of the film was also assessed by platelet adhesion and protein adsorption. The results suggest that the product has potential applications as a new biomaterial coating.

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The influence of polyelectrolyte charges of polyurethane membrane surface on the growth of human endothelial cells

Cited by 33 publications

References 19 publications

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

Synthesis of two-component injectable polyurethanes for bone tissue engineering

Film from peroxidation of an amino phospholipid and its biocompatibility

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