The influence of plasma protein binding on the extra-adrenal metabolism of cortisol in normal, hyperthyroid and hypothyroid subjects

Beisel, William R.; DiRaimondo, Vincent C.; Chao, Ping Yu; Rosner, Jorge M.; Forsham, Peter H.

doi:10.1016/0026-0495(64)90084-8

Cited by 31 publications

(5 citation statements)

References 18 publications

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“…Fractions (250 pl) were then carefully removed sequentially from the top of the tube and 25-OHD, vitamin D-binding protein and radioactivity measured. Vitamin D-binding protein was undetectable in the top four fractions and the percentage free 25-OHD was calculated (Beisel et al 1964).…”

Section: Identijication Of 25-0hd In Salivamentioning

confidence: 99%

Studies on the measurement of 25-hydroxy vitamin D in human saliva

Fairney

Saphier

1987

Br J Nutr

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1. A competitive protein-binding assay for 25-hydroxy vitamin D (25-OHD) in saliva has been established by adaptation of that previously described for 25-OHD in serum (Fairney et al. 1979).2. Random values of salivary 25-OHD in patients attending hospital for venesection showed a wide range of results (105-1000 pg/ml, n 55). These values corresponded to 1.2% of the total serum values with which they showed a significant relation (r 0.45, P < 0.001).3. There was no relation between salivary 25-OHD and measured serum free 25-OHD in eighteen pairs of saliva and serum studied. METHODS Collection of samplesUnstimulated samples of whole saliva (approximately 2 ml) were collected directly into glass bottles from normal volunteer subjects or patients attending for phlebotomy. Serum was collected simultaneously and all samples were stored in glass bottles at -20" until thawed before assay. Permission to collect these samples was obtained from the Local Ethical Commit tee.The saliva samples contained varying amounts of particulate matter to which 25-OHD3 bound on storage. To obtain a homogenous mixture for assay, the thawed samples were sonicated at amplitude 6 for 30 s before use, using a MSE Soniprep 150 (MSE Scientific Instruments, Crawley, Sussex).

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Section: Identijication Of 25-0hd In Salivamentioning

confidence: 99%

Studies on the measurement of 25-hydroxy vitamin D in human saliva

Fairney

Saphier

1987

Br J Nutr

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“…It is well known that thyroid disease can influence corticosteroid metabolism, hyperthyroidism being associated with increased catabolism of corticosteroids while the reverse occurs in hypothyroidism (Pittman, 1971). It has, for instance, been reported that in hyperthyroidism the plasma 17-OHCS remain in the low normal or slightly low range and the ACTH concentration increases (Hilton et a/., 1962) and that the rate of disappearance from plasma of both protein-bound and free cortisol is increased in hyperthyroidism and decreased in hypothyroidism (Beisel et al, 1964). It has also been reported that abnormalities in the binding of cortisol to plasma proteins occur in thyroid disease (Farese & Plager, 1962) although this could not be confirmed by Beisel et al (1964).…”

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confidence: 99%

The Adrenocortical Status of Patients With Thyroid Disease

Brien

1976

Clinical Endocrinology

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Summary. Plasma cortisol, cortisol resin uptake ratio and free cortisol index was measured in twenty‐seven euthyroid, ten hypothyroid and fifteen hyperthyroid subjects. No difference was observed between euthyroid subjects and patients with thyroid disease for any of the three parameters tested. The significance of these findings is discussed in the light of earlier reports linking thyroid activity with the levels of corticosteroid binding globulin.

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“…Hypothyroid patients have a slower turnover of Cortisol. Both bound and free steroid fraction disappearance rates were slower than normal or hyperthyroid patients (Beisel et al_. , 1964).…”

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confidence: 72%

Interrelationships of certain thermal and endocrine phenomena and reproductive function in the female bovine / by Francis Charles Gwazdauskas.

Gwazdauskas¹

1974

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Simple correlations between hormone measurements. 37 Physical characteristics of plasma in heifers at^9 21.3 C and 32.0 C. Overall least squares analyses of variance for 96 hormones in heifers at 21.3 C and 32.0 C. Plasma progestins (ng/ml) following PGF^injection. 97 Plasma estradiol (pg/ml) following PGFp injection. 98 Plasma estrone (pg/ml) following PGFp injection. 99 Plasma LH (ng/ml) following PGFp injection. 100 Plasma prolactin (ng/ml) following PGFp injection. 101 Plasma corticoids (ng/ml) following PGFp injection. 102 11 Plasma corticoids (ng/ml) prior to and following 103 200 lU ACTH. Plasma progestins (ng/ml) prior to ACTH injection. 104 Simple correlations betv;een hormones and temperatures. 105 Analysis of variance for aortic and uterine temperatures. 106 Hormonal and temperature measurements for 6665 (6) and 107 JN15 (J). VI 9 Uterine and aortic temperature prior to and following 65 IV injection of 12 ml sterile physiological saline. 10 Uterine and aortic temperature prior to and following 67 IV injection of 3 mg estradiol-17e. 11 ATuterus-aorta P'^'o'' to and following either 12 ml 69 saline or 3 mg estradiol-17B. vn-List of Figures (continued); Figure Page No. 12 Uterine and aortic temperature prior to and after injection of estradiol-17e from continuous recording. 13 Uterine and aortic temperatures prior to and following PGFo injections in G665. CO. 14 Uterine and aortic temperatures prior to and follov/ing PGFo injections in JN15. ca 15 Changes in aT, , following PGF, injections. u-a CO. 16 Uterine and aortic temperatures, LH and estradiol in G655 and air temperatures. 17 Uterine and aortic temperatures, LH and estradiol in JN15 and air temperatures. 18 Circadian uterine, aortic and air temperature changes.

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The influence of plasma protein binding on the extra-adrenal metabolism of cortisol in normal, hyperthyroid and hypothyroid subjects

Cited by 31 publications

References 18 publications

Studies on the measurement of 25-hydroxy vitamin D in human saliva

Studies on the measurement of 25-hydroxy vitamin D in human saliva

The Adrenocortical Status of Patients With Thyroid Disease

Interrelationships of certain thermal and endocrine phenomena and reproductive function in the female bovine / by Francis Charles Gwazdauskas.

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