The influence of plaque composition on underlying arterial wall stress during stent expansion: The case for lesion-specific stents

Pericevic, Ian Owens; Lally, Caitríona; Toner, Deborah; Kelly, Daniel J.

doi:10.1016/j.medengphy.2008.11.005

Cited by 150 publications

(126 citation statements)

References 35 publications

(48 reference statements)

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“…These computational methods of analysis employ sophisticated numerical techniques, such as the finite element and finite volume methods, to obtain approximate numerical solutions to complex physical problems. To date, a large number of studies have carried out computational structural (CS) analyses 1,4,5,14,15,19,[25][26][27][28][29]37,44,53,54,57,59,[62][63][64]72,73,78,80,85,87,[90][91][92] and computational fluid dynamics (CFD) analyses 3,8,9,12,30,31,33,42,[47][48][49][50][51]65,66,69,[74][75][76]83,89 ...…”

Section: Introductionmentioning

confidence: 99%

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Martín¹,

Boyle²

2015

Cardiovasc Eng Tech

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Abstract-Several clinical studies have identified a strong correlation between neointimal hyperplasia following coronary stent deployment and both stent-induced arterial injury and altered vessel hemodynamics. As such, the sequential structural and fluid dynamics analysis of balloon-expandable stent deployment should provide a comprehensive indication of stent performance. Despite this observation, very few numerical studies of balloon-expandable coronary stents have considered both the mechanical and hemodynamic impact of stent deployment. Furthermore, in the few studies that have considered both phenomena, only a small number of stents have been considered. In this study, a sequential structural and fluid dynamics analysis methodology was employed to compare both the mechanical and hemodynamic impact of six balloon-expandable coronary stents. To investigate the relationship between stent design and performance, several common stent design properties were then identified and the dependence between these properties and both the mechanical and hemodynamic variables of interest was evaluated using statistical measures of correlation. Following the completion of the numerical analyses, stent strut thickness was identified as the only common design property that demonstrated a strong dependence with either the mean equivalent stress predicted in the artery wall or the mean relative residence time predicted on the luminal surface of the artery. These results corroborate the findings of the large-scale ISAR-STEREO clinical studies and highlight the crucial role of strut thickness in coronary stent design. The sequential structural and fluid dynamics analysis methodology and the multivariable statistical treatment of the results described in this study should prove useful in the design of future balloon-expandable coronary stents.

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Section: Introductionmentioning

confidence: 99%

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Martín¹,

Boyle²

2015

Cardiovasc Eng Tech

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“…Without considering such phenomena it will not be possible to develop models to accurately predict lumen gain during clinical procedures such as angioplasty and stenting (Early and Kelly, 2011;Early and Kelly, 2010;Early et al, 2009;Pericevic et al, 2009). In this study an anisotropic inelastic constitutive model is formulated to describe stress softening and permanent set for arterial tissue.…”

Section: Introductionmentioning

confidence: 99%

An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue

Maher

Creane

Lally

et al. 2012

Journal of the Mechanical Behavior of Biomedical Materials

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A n anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue A bstractInelastic phenomena such as softening and unrecoverable inelastic strains induced by loading have been observed experimentally in soft tissues such as arteries. These phenomena need to be accounted for in constitutive models of arterial tissue so that computational models can accurately predict the outcomes of interventional procedures such as balloon angioplasty and stenting that involve non-physiological loading of the tissue. In this study, a novel constitutive model is described that accounts for inelastic effects such as Mullins-type softening and permanent set in a fibre reinforced tissue. The evolution of inelasticity is governed by a set of internal variables. Softening is introduced through a typical continuum damage mechanics approach, while the inelastic residual strains are introduced through an additive split in the stress tensor. Numerical simulations of aorta and carotid arterial tissue subjected to uniaxial testing in the longitudinal, circumferential and axial directions reproduce the anisotropic inelastic behaviour of the tissue. Material parameters derived from best-fits to experimental data are provided to describe these inelastic effects for both aortic and carotid tissue.

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“…Other applications of finite element simulations have been proposed, for the placement of a stent in the context of EVAR procedures 22 , or in the peripheral vessels [23][24][25][26][27] .…”

Section: Discussionmentioning

confidence: 99%

Prediction of deformations during endovascular aortic aneurysm repair using finite element simulation

Kaladji

Dumenil

Castro

et al. 2013

Computerized Medical Imaging and Graphics

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During endovascular aortic aneurysm repair (EVAR), the introduction of medical devices deforms the arteries. The aim of the present study was to assess the feasibility of finite element simulation to predict arterial deformations during EVAR. The aortoiliac structure was extracted from the preoperative CT angiography of fourteen patients who underwent EVAR.The simulation consists of modeling the deformation induced by the stiff guidewire used during EVAR. The results of the simulation were projected onto the intraoperative images, using a 3D/2D registration. The mean distance between the real and simulated guidewire was 2.3 ± 1.1 mm. Our results demonstrate that finite element simulation is feasible and appears to be reproducible in modeling device/tissue interactions and quantifying anatomic deformations during EVAR.

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The influence of plaque composition on underlying arterial wall stress during stent expansion: The case for lesion-specific stents

Cited by 150 publications

References 35 publications

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

Sequential Structural and Fluid Dynamics Analysis of Balloon-Expandable Coronary Stents: A Multivariable Statistical Analysis

An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue

Prediction of deformations during endovascular aortic aneurysm repair using finite element simulation

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