The influence of plant stanol (β-sitostanol) on inner leaflet of human erythrocytes membrane modeled with the Langmuir monolayer technique

Hąc-Wydro, Katarzyna; Lenartowicz, Róża; Dynarowicz-Łątka, Patrycja

doi:10.1016/j.colsurfb.2012.07.048

Cited by 17 publications

(6 citation statements)

References 42 publications

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“…The excess Gibbs free energy (Δ G ex ) was used to quantitatively analyze the information of the thermodynamic stability of mixed monolayers; Δ G ex can be calculated from the following equation [ 31 , 32 ]:

where A exp represents the experimental mean molecular area. A 1 and A 2 denote the mean molecular areas of components 1 and 2 at a definite surface pressure, respectively.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Hao

Zhang

et al. 2017

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Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and a mixture of DPPC with curcumin (CUR) have been investigated at the air-water interface through a combination of surface pressure measurements and atomic force microscopy (AFM) observation. By analyzing the correlation data of mean molecular areas, the compressibility coefficient, and other thermodynamic parameters, we obtained that the interaction between the two components perhaps was mainly governed by the hydrogen bonding between the amino group of DPPC and the hydroxyl groups of CUR. CUR markedly affected the surface compressibility, the thermodynamic stability, and the thermodynamic phase behaviors of mixed monolayers. The interaction between CUR and DPPC was sensitive to the components and the physical states of mixed monolayers under compression. Two-dimensional phase diagrams and interaction energies indicated that DPPC and CUR molecules were miscible in mixed monolayers. AFM images results were in agreement with these analyses results of experimental data. This study will encourage us to further research the application of CUR in the biomedical field.

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where A exp represents the experimental mean molecular area. A 1 and A 2 denote the mean molecular areas of components 1 and 2 at a definite surface pressure, respectively.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Hao

Zhang

et al. 2017

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“…Experimentally, each plant sterol interacts differently with the membrane, and the subtle differences in the structure of the sterol molecules may cause significant differences in the membrane properties . Animal cells are fine‐tuned to maintain a stable cell membrane fluidity via cholesterol, and replacing cholesterol with plant sterols may alter the balance of the membrane significantly by altering the pressure profile along the membrane normal . In MD simulations, replacing cholesterol with plant sterols affects the thickness of the layer, the sterol orientation, membrane fluidity and elastic properties of membranes .…”

Section: Interactions Of Plant Extracts With Bilayersmentioning

confidence: 99%

Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes

2013

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Several small drugs and medicinal plant extracts, such as the Indian spice extract curcumin, have a wide range of useful pharmacological properties that cannot be ascribed to binding to a single protein target alone. The lipid bilayer membrane is thought to mediate the effects of many such molecules directly via perturbation of the plasma membrane structure and dynamics, or indirectly by modulating transmembrane protein conformational equilibria. Furthermore, for bioavailability, drugs must interact with and eventually permeate the lipid bilayer barrier on the surface of cells. Biophysical studies of the interactions of drugs and plant extracts are therefore of interest. Molecular dynamics simulations, which can access time and length scales that are not simultaneously accessible by other experimental methods, are often used to obtain quantitative molecular and thermodynamic descriptions of these interactions, often with complementary biophysical measurements. This review considers recent molecular dynamics simulations of small drug‐like molecules with membranes, and provides a biophysical description of possible routes of membrane‐mediated pharmacological effects of drugs. The review is not exhaustive, and we focus on molecules containing aromatic ring‐like structures to develop our hypotheses. We also show that some drugs and anesthetics may have an effect on the lipid bilayer analogous to that of cholesterol.

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“…Since the images for one component films of the respective lipids investigated herein were presented in literature [26][27][28][29][30][31], they are not shown in this work. In short, BAM images taken for POPC film reflect a homogenous monolayer.…”

Section: Bam Imagesmentioning

confidence: 99%

“…These domains denote the occurrence of phase transition between expanded and condensed phase, clearly noticeable in the isotherm. With further compression (see picture at ≈ 20 mN/m) these domains enlarge and take a snowflake shape characteristic for pure POPE monolayer [29,30]. The number of these condensed phase increases up to the collapse point.…”

Section: Bam Imagesmentioning

confidence: 99%

The influence of cholesterol on multicomponent Langmuir monolayers imitating outer and inner leaflet of human erythrocyte membrane

Wydro¹

2013

Colloids and Surfaces B: Biointerfaces

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The influence of plant stanol (β-sitostanol) on inner leaflet of human erythrocytes membrane modeled with the Langmuir monolayer technique

Cited by 17 publications

References 42 publications

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Investigation of Surface Behavior of DPPC and Curcumin in Langmuir Monolayers at the Air-Water Interface

Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes

The influence of cholesterol on multicomponent Langmuir monolayers imitating outer and inner leaflet of human erythrocyte membrane

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