The influence of placebo awareness on stimulant drug response in a double-blind trial

Nash, Justin M.; Holroyd, Kenneth A.; Rokicki, Lori A.; Kvaal, Steven A.; Penzien, Donald

doi:10.1007/s00213-002-1050-1

Cited by 12 publications

(10 citation statements)

References 19 publications

(34 reference statements)

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“…This finding is in accordance with the results of previous studies (24,35). In the study of Nash et al (24), negative results were obtained following the intake of both 125 mg and 325 mg caffeine, and the latter dosage is comparable to that used in the recent study. According to these findings, caffeine may affect vigilance and psychomotor performance but has no direct impact on reaction time.…”

Section: Discussionsupporting

confidence: 82%

“…This negative finding is in accordance with the results of other caffeine studies (24,46,47), while differences between the effects of the two administration methods were found in pain-related clinical and experimental placebo studies (30,43,44). According to these findings, results obtained from laboratory experiments using caffeine cannot be generalized to medical problems (i.e.…”

Section: Discussionsupporting

confidence: 76%

“…As caffeine had an impact on HRV-SDNN which reflects all cyclic components responsible for HR variability and had no impact on the more specific HF and LF/HF indices, no conclusions can be drawn regarding the autonomic background of this change. Although the hypertensive effect of caffeine is generally accepted (6,11,12,17,22,24,35), it was not demonstrated in all studies (17,37). HR-related results are also mixed.…”

Section: Discussionmentioning

confidence: 77%

“…HR-related results are also mixed. While no changes following caffeine consumption were detected in some studies (6,11,12,17,24,37), a significant decrease in HR was reported in others (22,35,40,49). Reduction of HR possibly reflects a baroreceptor mediated response to pressor action (28).…”

Section: Discussionmentioning

confidence: 98%

“…In summary, the information given to participants about the likelihood of receiving the active substance (stimulus expectancy) had an impact on certain variables in both the placebo and the caffeine groups. Interestingly, in other studies with placebo-groups only (46,47) or with placebo and caffeine groups (24), no such differences were found.…”

mentioning

confidence: 87%

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Subjective and objective effects of coffee consumption — caffeine or expectations?

Dömötör¹,

Szemerszky²,

Köteles³

2015

Acta Physiologica Hungarica

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Impact of 5 mg/kg caffeine, chance of receiving caffeine (stimulus expectancies), and expectations of effects of caffeine (response expectancies) on objective (heart rate (HR), systolic/diastolic blood pressure (SBP/DBP), measures of heart rate variability (HRV), and reaction time (RT)) and subjective variables were investigated in a double-blind, placebo-controlled experiment with a no-treatment group. Participants were 107 undergraduate university students (mean age 22.3 ± 3.96 years). Consumption of 5 mg/kg caffeine had an impact on participants' SBP, standard deviation of normal heartbeat intervals, HR (decrease), and subjective experience 40 minutes later even after controlling for respective baseline values, stimulus and response expectancies, and habitual caffeine consumption. No effects on DBP, high frequency component of HRV, the ratio of low-and high-frequency, and RT were found. Beyond actual caffeine intake, response expectancy score was also a determinant of subjective experience which refers to a placebo component in the total effect. Actual autonomic (SBP, HR) changes and somatosensory amplification tendency, however, had no significant impact on subjective experience. Placebo reaction plays a role in the subjective changes caused by caffeine consumption but it has no impact on objective variables. Conditional vs deceptive administration of caffeine (i.e. stimulus expectancies) had no impact on any assessed variable.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 87%

See 3 more Smart Citations

Subjective and objective effects of coffee consumption — caffeine or expectations?

Dömötör¹,

Szemerszky²,

Köteles³

2015

Acta Physiologica Hungarica

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Current Awareness in Human Psychopharmacology

2002

Human Psychopharmacology

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of human psychopharmacology. Each bibliography is divided into 18 sections: 1 Books, Reviews & Symposia; 2 General; 3 Psychotropic Drugs ‐ General; Antidepressive Agents: 4 Tricyclics; 5 Monoamine Oxidase Inhibitors; 6 Serotonergics; Euthymic Agents: 7 Lithium; Tranquillizing Agents: 8 Major; 9 Minor & Hypnotics; 10 Analeptic Agents; 11 Anticonvulsant Agents; 12 Drugs of Abuse; 13 Transmitters, Receptors, Metabolites & Modulating Agents; 14 Neuropeptides; 15 Psychoneuroendocrinology; 16 Psychoneuroimmunology; 17 Behavioural Genetics; 18 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Can We Trust Our Body Feelings? The Discrepancy Between Actual and Perceived Events

Köteles

2021

Body Sensations

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The influence of placebo awareness on stimulant drug response in a double-blind trial

Cited by 12 publications

References 19 publications

Subjective and objective effects of coffee consumption — caffeine or expectations?

Subjective and objective effects of coffee consumption — caffeine or expectations?

Current Awareness in Human Psychopharmacology

Can We Trust Our Body Feelings? The Discrepancy Between Actual and Perceived Events

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