The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders

Stojanoska, Milica Medić; Milošević, Nataša; Milić, Nataša; Abenavoli, Ludovico

doi:10.1007/s12020-016-1158-4

Cited by 154 publications

(108 citation statements)

References 125 publications

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“…Metabolic syndrome that is characterized by the coincidence of hypertension, dyslipidemia, abdominal obesity, and hyperglycemia, is a main predisposing factor of cardiovascular diseases. Diet, sedentary lifestyle as well as exposing to endocrine disturbing chemicals as the case bisphenol A (BPA) have been promoting impacts on the characteristic feature of the metabolic syndrome (Stojanoska, Milosevic, Milic, & Abenavoli, ).…”

Section: Introductionmentioning

confidence: 99%

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Rameshrad

Razavi

Imenshahidi

et al. 2019

Phytotherapy Research

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The mechanisms of bisphenol‐A (BPA)‐induced metabolic syndrome as well as the protective role of grape seed extract (GSE) and resveratrol were investigated. Rats were treated with BPA (0 and 35 mg·kg−1·day−1, gavage) plus resveratrol (25, 50, and 100 mg·kg−1·day−1, i.p.) or GSE (3, 6, 12 mg·kg−1·day−1, i.p.) or vitamin E (200 IU/kg/every other day, i.p.). After 2 months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme‐linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real‐time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (LDLR, CYP7A1, ABCG5 and 8) and insulin signaling (p‐Akt/Akt and p‐PI3K/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low‐density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both ABCG5 and ABCG8. It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p‐Akt/Akt and p‐PI3K/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels. Herein, the predisposing effects of BPA‐induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling, ABCG8 expression, and their antioxidant properties.

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Section: Introductionmentioning

confidence: 99%

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Rameshrad

Razavi

Imenshahidi

et al. 2019

Phytotherapy Research

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“…Several molecular targets have been identified to explain the obesogenic effect of BPA . Indeed, it has been reported that BPA, in concentration ranges of μ m , interacts with Nuclear Receptors (NR), Estrogen Receptors (ER), Glucocorticoid Receptors (GR), peroxisome proliferator‐activated receptor γ (PPARγ), the Retinoid X Receptor (RXR) and Thyroid Receptors (TR) .…”

Section: Obesogenic Activity Of Bisphenol Amentioning

confidence: 99%

“…Epidemiological studies Several recent reviews have been published concerning epidemiological data and the link between BPA exposure and obesity [39,[48][49][50][51].…”

Section: Impact Of Bpa In Obesitymentioning

confidence: 99%

“…All together, these results suggest that BPA, in a lM concentration range, induces adipocyte differentiation, and in a nM concentration range, induces an adipocyte dysfunction reflected by a decrease in insulin sensitivity and a stimulation of pro-inflammatory responses. Several molecular targets have been identified to explain the obesogenic effect of BPA [39,51,125]. Indeed, it has been reported that BPA, in concentration ranges of lM, interacts with Nuclear Receptors (NR), Estrogen Receptors (ER), Glucocorticoid Receptors (GR), peroxisome proliferator-activated receptor c (PPARc), the Retinoid X Receptor (RXR) and Thyroid Receptors (TR) [126][127][128][129].…”

Section: In Vitro Studiesmentioning

confidence: 99%

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Is bisphenol A an environmental obesogen?

Legeay

Faure

2017

Fundamemntal Clinical Pharma

104

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Bisphenol A (BPA) is an endocrine disruptor with an oestrogenic activity that is widely produced for the manufacture of polycarbonate plastic, epoxy resin, and thermal paper. Its ubiquitous presence in the environment contributes to broad and continuous human exposure, which has been associated with deleterious health effects. Despite numerous controversial discussions and a lack of consensus about BPA's safety, growing evidence indicates that BPA exposure positively correlates with an increased risk of developing obesity. An updated analysis of the epidemiological, in vivo, and in vitro studies indicates that BPA should be considered an obesogenic environmental compound. Precisely, BPA exposure during all life stages correlates with increased body weight and/or body mass index. Developmental periods that include prenatal, infancy, and childhood appear to be critical windows with increased sensitivity to BPA effects. Finally, blood analysis and in vitro data clearly demonstrate that BPA promotes adipogenesis, lipid and glucose dysregulation, and adipose tissue inflammation, thus contributing to the pathophysiology of obesity. Future prevention efforts should now be employed to avoid BPA exposure, and more research to determine in depth the critical time windows, doses, and impact of long-term exposure of BPA is warranted in order to clarify its risk assessment.

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“…Hence, BPFL is used as a substitute of BPA in the production of “BPA‐free” plastics . The estrogenic activity of BPA and its substitutes are known to cause various reproductive and metabolic disorders such as obesity, type‐2 diabetes mellitus ,. However human exposure to BPFL and its effects is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Structural, Vibrational Properties and Electronic Structure of Fluorene‐9‐Bisphenol: A DFT Approach

et al. 2018

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Bisphenol A (BPA) is a chemical used in a variety of materials and has adverse effects on endocrine system. The substitutes of BPA have been developed to produce BPA-free plastics. Fluorene-9-bisphenol (BPFL), has anti-oestrogenic effects, is one of those substitutes used in 'BPA-free' bottles. In this study, the physical, electronic and vibrational properties of BPFL molecule are investigated using density functional theory (DFT) calculations at B3LYP/6-311G (d, p) basis set. Bond distances, Fourier transform infrared (FT-IR) spectra, natural atomic charges, solvation energies, dipole moments and vibrational frequencies were carried out. The calculated bond distance for the optimized geometry of BPFL obtained from DFT calculations were compared with the measured results. Structural properties like radial distribution function (RDF) and probability distribution depending on coordination number have been calculated for the molecule. Ultraviolet-visible (UV-Vis) spectra characteristics and the electronic features, such as absorption wavelengths, frontier orbitals, excitation energies and band gap energy of BPFL were also recorded using time-dependent (TD) DFT approach based on optimized structure with different solvent environments. Finally, we investigated the effects of solvents on structural, electronic and vibrational frequencies of BPFL molecule.[a] Dr.

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The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders

Cited by 154 publications

References 125 publications

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Is bisphenol A an environmental obesogen?

Investigation of Structural, Vibrational Properties and Electronic Structure of Fluorene‐9‐Bisphenol: A DFT Approach

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