The Influence of Pharmaceutical Compounds on Male Fertility*

Neumann, F.; Fa, Diallo; Sh, Hasan; Schenck, B.; I, Traore

doi:10.1111/j.1439-0272.1976.tb02137.x

Cited by 50 publications

(10 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neben der Erektionsstörung entwickeln die Patienten unter Androgenablation eine Hodenfibrosierung, eine Abnahme des Hodenvolumens und eine Beeinträchtigung der Spermiogenese. Diese Effekte treten bereits kurz nach Einleitung der Therapie auf, sind dosisabhängig und scheinen jedoch reversibel zu sein [19,38,39]. Es liegen allerdings keine Langzeitergebnisse über die Auswirkungen auf die Fertilität bei jungen initial fertilen Männern unter LHRH-Therapie vor.…”

Section: Unerwünschte Wirkungenunclassified

Die antiandrogene Therapie aus urologischer Sicht

Korda

Sommer

2010

Forens Psychiatr Psychol Kriminol

View full text Add to dashboard Cite

Ü b e r s i c h tZusammenfassung testosteron, das für den Mann wichtigste sexualsteroid sowie seine Metaboliten Dihydrotestosteron (Dht) und estradiol (e2) steuern zentral und peripher eine Vielzahl von sexualspezifischen sowie unspezifischen Abläufen. Die fördernde Wirkung von freiem Testosteron auf die Frequenz der sexuellen Gedanken und die Häufigkeit von sexuellen Handlungen macht man sich in der Behandlung von Paraphilien zunutze und senkt den Androgenspiegel medikamentös unter das Kastrationsniveau von 50 ng/dl (1,735 nmol/l). Unerwünschte Wirkungen dieser antiandrogenen Therapie sind in der Regel reversibel und umfassen psychische Symptome wie Reizbarkeit, depressive Verstimmung und Gedächtnisschwäche ebenso wie eine Vielzahl körperlicher Symptome wie z. B. negative metabolische und kardiovaskuläre Veränderun-gen, Muskel-und Gelenkschmerzen sowie eine Reduktion der Knochenmineralsubstanz. Wichtigste unerwünschte Wirkungen im urologischen Bereich sind die erektile Dysfunktion und die Beeinträchtigung der Spermiogenese bis hin zur Infertilität. Da der Testosteronwert invers mit dem Risiko und der Aggressivität eines Prostatakarzinoms zu korrelieren scheint, ist die regelmäßige urologische Vorsorge von großer Wichtigkeit. Patienten, die sich einer antiandrogenen Therapie unterziehen, sollten regelmäßig überwacht werden, um Komplikationen zu verhindern oder rechtzeitig zu diagnostizieren und behandeln zu können.Schlüsselwörter Paraphilie · Cyproteronacetat · Agonist des luteinisierenden Hormon-Releasing-Hormons · Androgendeprivation · Komplikationen · Nebenwirkung · Pharmakotherapie Anti-androgen treatment of paraphilias from the urologist's perspective Abstract Testosterone, the most important male sex steroid and its metabolites dihydrotestosterone (DHT) and estradiol (E2) regulate a vast number of central and peripheral specific and non-specific sexual processes. Free testosterone facilitates the frequency of sexual thoughts and acts. This concept is used in the treatment of paraphilia by medicinally decreasing the level of testosterone to under the castration level of 50 ng/dl (1.735 nmol/l). Adverse drug reactions of this anti-androgen therapy are usually reversible and include mental symptoms, such as irritability, depressive episodes and weakness of memory, as well as a variety of physical symptoms, such as negative metabolic and cardiovascular changes, muscle and joint pain plus a reduction of bone mineral mass. The most important urologic adverse events include erectile dysfunction and impairment of spermatogenesis up to infertility. Testosterone levels seem to correlate inversely with the risk and aggression of prostate cancer and therefore urologic prevention is of prime importance. Patients on anti-androgen treatment should receive regular monitoring and therapy aimed at preventing or treating antiandrogen-induced complications.

show abstract

Section: Unerwünschte Wirkungenunclassified

Die antiandrogene Therapie aus urologischer Sicht

Korda

Sommer

2010

Forens Psychiatr Psychol Kriminol

View full text Add to dashboard Cite

show abstract

“…The inhibitory effect of CA on the male reproductive tract, including the involution of the prostate, seminal vesicles and epididymis has been well documented in a number of mammalian species (Neumann et al, 1976;Kumar & Panda, 1983;Habenicht & El Etreby, 1989;Kaur et al, 1990Kaur et al, , 1991. Treatment with CA also induces a severe impairment of the testis, comprising weight loss, arrest of spermatogenesis, and a decrease in the production of some secretory proteins, such as androgen binding protein (ABP) (Neumann et al, 1976;Schenck & Neumann, 1978;Kalla & Bhasin, 1983;Bhiwgade et al, 1990). In most species studied, CA inhibits the gonadal function by interfering with the androgenic stimulation.…”

Section: Introductionmentioning

confidence: 99%

“…In most species studied, CA inhibits the gonadal function by interfering with the androgenic stimulation. This compound displaces androgens from its receptors and also reduces gonadotropin release through the negative feedback on the hypothalamic-pituitary axis, acting in this way as a progestin (Neumann et al, 1976;Brinkmann et al, 1983;Knuth et al, 1984;Abdulmaged et al, 1985;Huang et al, 1985;Poyet & Labrie, 1985). It has been demonstrated that CA may also have direct negative effects on the synthesis of androgens, through the inhibition of some microsomal enzymes involved in steroidogenic testicular pathways (Ayub & Levell, 1987;Clos et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

Effects of cyproterone acetate on the reproductive tract and pituitary-gonadal axis of the golden hamster

Balbontin

Ferrario

2009

Andrologia

View full text Add to dashboard Cite

The effects of cyproterone acetate (CA) on the reproductive tract and serum levels of gonadotropins and testosterone in male golden hamsters exposed to long days, were studied. The daily injection of CA at 100 mg kg-' body weight during 8 weeks reduced sperm count, both in caput and cauda epididymidis. The weight of epididymis and seminal vesicles were also reduced, while testicular weight and histology were not affected. Serum levels of testosterone and LH were increased 3.6 and 1.8 fold, respectively, above controls, while FSH was not affected by the treatment with CA. The absence of an inhibitory action of CA on the testis could be explained through an increase in L H stimulation, thus suggesting that in the golden hamster CA is devoid of progestagenic partial effects.

show abstract

“…Exogenous steroids, such as progestins and androgens, suppress estrus via inhibition of pituitary gonadotropin secretion and release (NEUMANN et al, 1976). Among progestins, megestrol acetate, medroxyprogesterone acetate (MPA), proligestone are used.…”

Section: Conservative Treatment/management Of Orsmentioning

confidence: 99%

“…In the queen, megestrol acetate is mainly used orally at a dose 5 mg/cat for 3 days followed by 2.5 to 5 mg/week for 10 weeks (BURKE, 1982;FELDMAN;NELSON, 2004). This treatment has suppressed estrus in 92% of the patients but, despite its efficiency, reported side effects in the bitch and queen include: change in temperament, increasing appetite leading to weight gain, growth hormone secretion with resultant signs of acromegalia and insulin resistance REYNOLDS, 1975;NEUMANN et al, 1976;EIGENMANN, 1986), mammary hyperplasia and/or neoplasms (SOREMNO et al, 2000;STONE, 2003), stump pyometra (HAGMAN, 2004), reversible transitory hypoadrenocorticism ( VAN DEN BROEK;O'FARRELL, 1994) as well as other clinical signs consistent with adrenocortical suppression (i.e. alopecia, hair discoloration, thinning of the skin and mobilization of subcutaneous fat) (KUTZLER; WOODS, 2006).…”

Section: Conservative Treatment/management Of Orsmentioning

confidence: 99%

Ovarian remnant syndrome in small animals

et al. 2012

View full text Add to dashboard Cite

The ovarian remnant syndrome (ORS) is an iatrogenic disorder in bitches and queens, which is characterized by recurrence of estrus following surgical spay, due to the presence of a piece of ovarian tissue within the abdominal cavity. In most cases, the remnant ovary is found in the right ovarian pedicle, due to its topographic position, deeper and more cranial than the left ovary. The main clinical signs of ORS in small animals are the heat behavior and the presence of vaginal swelling/secretion, especially in canines. The diagnosis should be performed by means of vaginal cytology when attraction of males is detected, serum estrogen and progesterone levels and/or by challenging test with GnRH or hCG administration. However, vaginal citology is the most suitable and less expensive diagnostic tool. Nowadays the treatment of choice is a new laparotomy or laparoscopy, followed by removal of the remnant ovarian tissue. The surgical treatment has more chances of success if it is performed in the diestrus (i.e., between 15 and 60 days after the detection of attraction of males). Furthermore, a careful and accurate surgical procedure aided by advanced visualization techniques during ovariohysterectomy or ovariectomy is the best way to prevent ORS in companion animals. Key words: Partial ovarian spay, recurrent estrus, bitches, queens ResumoA síndrome do ovário remanescente (SOR) é um distúrbio iatrogênico em cadelas e gatas caracterizado pelo retorno do estro após contracepção cirúrgica devido à presença de fragmento de tecido ovariano na cavidade abdominal. Frequentemente, o ovário remanescente está situado no pedículo ovariano direito, sobretudo devido a sua posição topográfica mais profunda e cranial em comparação ao ovário esquerdo. Os principais sinais clínicos de SOR em pequenos animais são cio e presença de edemaciamento/secreção vulvar/vaginal, especialmente em caninos. O diagnóstico deve ser realizado por meio de citologia vaginal quando detecta-se o interesse dos machos pela cópula com a fêmea acometida, dosagem sérica de estrógeno e progesterona e/ou por meio do teste provocativo com administração de GnRH ou hCG. Contudo, citologia vaginal constitui a opção de melhor custo-benefício para o diagnóstico. Atualmente, o tratamento de escolha é cirúrgico por meio de laparotomia exploratória ou laparoscopia, seguido pela remoção do ovário remanescente. O tratamento cirúrgico tem maiores taxas de sucesso quando realizado com o animal em diestro (i.e., entre 15 e 60 dias após detectada a atração dos machos). Ademais, a

show abstract

The Influence of Pharmaceutical Compounds on Male Fertility*

Cited by 50 publications

References 92 publications

Die antiandrogene Therapie aus urologischer Sicht

Die antiandrogene Therapie aus urologischer Sicht

Effects of cyproterone acetate on the reproductive tract and pituitary-gonadal axis of the golden hamster

Ovarian remnant syndrome in small animals

Contact Info

Product

Resources

About