The Influence of Permanent Magnetic Field Therapy on Wound Healing in Suction Lipectomy Patients: A Double-Blind Study

Man, Daniel; Man, Boris; Plosker, Harvey

doi:10.1097/00006534-199912000-00053

Cited by 50 publications

(27 citation statements)

References 10 publications

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“…It is also clear that cells undergoing tumorigenesis have been observed to have altered cytoskeletons with enhanced motility and less polarity [30]–[31]. Similar effects were also observed in migrating cells during many biological processes, such as tissue repair and regeneration [1], [2], [18], [19]. All of these cytoskeletal dynamics of migrating cells are highly associated with the EGFR signal pathway because there is intensive cross talk between the cytoskeleton and the EGFR signal pathways.…”

Section: Discussionmentioning

confidence: 76%

Weak Power Frequency Magnetic Field Acting Similarly to EGF Stimulation, Induces Acute Activations of the EGFR Sensitive Actin Cytoskeleton Motility in Human Amniotic Cells

Cao

Shen

et al. 2014

PLoS ONE

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In this article, we have examined the motility-related effects of weak power frequency magnetic fields (MFs) on the epidermal growth factor receptor (EGFR)-sensitive motility mechanism, including the F-actin cytoskeleton, growth of invasive protrusions and the levels of signal molecules in human amniotic epithelial (FL) cells. Without extracellular EGF stimulation, the field stimulated a large growth of new protrusions, especially filopodia and lamellipodia, an increased population of vinculin-associated focal adhesions. And, an obvious reduction of stress fiber content in cell centers was found, corresponding to larger cell surface areas and decreased efficiency of actin assembly of FL cells in vitro, which was associated with a decrease in overall F-actin content and special distributions. These effects were also associated with changes in protein content or distribution patterns of the EGFR downstream motility-related signaling molecules. All of these effects are similar to those following epidermal growth factor (EGF) stimulation of the cells and are time dependent. These results suggest that power frequency MF exposure acutely affects the migration/motility-related actin cytoskeleton reorganization that is regulated by the EGFR-cytoskeleton signaling pathway. Therefore, upon the MF exposure, cells are likely altered to be ready to transfer into a state of migration in response to the stimuli.

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Section: Discussionmentioning

confidence: 76%

Weak Power Frequency Magnetic Field Acting Similarly to EGF Stimulation, Induces Acute Activations of the EGFR Sensitive Actin Cytoskeleton Motility in Human Amniotic Cells

Cao

Shen

et al. 2014

PLoS ONE

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“…[Eccles, 2005;Salomonowitz et al, 2011]. Several studies have reported that SMF can reduce patients' pain sensitivity, and reduce pain of various diseases, such as, all chronic pain [Brown et al, 2002;Langford and McCarthy, 2005;Kanai et al, 2011], osteoarthritis pain [Segal et al, 2001;Harlow et al, 2004;Wolsko et al, 2004], neuropathic pain [Weintraub et al, 2003], and postoperative pain [Man et al, 1999]. Except for clinical trials, animal experiments have also been performed to prove analgesia effects of SMF [Antal and Laszlo, 2009;Laszlo and Hernadi, 2012].…”

Section: Introductionmentioning

confidence: 99%

Effect of static magnetic field on pain level and expression of P2X3 receptors in the trigeminal ganglion in mice following experimental tooth movement

Zhu

Wang

Long

et al. 2016

Bioelectromagnetics

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Recent research has demonstrated that static magnetic fields (SMF) can generate an analgesic effect in different conditions. The present study explored effects of SMF on pain levels and expressions of P2X3 receptors in trigeminal ganglion (TG) in mice after experimental tooth movement (tooth movement induced by springs between teeth). Experiments were performed in male mice (body mass: 25-30 g) and divided into SMF + force group, force group, and no force group. Exposure time was over 22 h per day. Mouse Grimace Scale was used for evaluating orofacial pain levels during experimental tooth movement at 4 h and 1, 3, 7, and 14 days. Meanwhile, expression levels of P2X3 receptors in the TG were evaluated by immunohistochemistry and western blotting at same time points. We finally found that during experimental tooth movement, pain levels of mice peaked at 3 days, and then decreased. While pain levels of mice were reduced in the SMF environment at 4 h, 1 and 3 days, there was a significant difference at 1 and 3 days. Meanwhile, under the action of SMF, expression levels of P2X3 receptors in TG were significantly lower at 4 h, 3 and 7 days. These results suggest that SMF can reduce pain levels in mice, and down-regulate P2X3 receptors in TG. Bioelectromagnetics. 38:22-30, 2017. © 2016 Wiley Periodicals, Inc.

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“…Biophysical forces such as electromagnetic fields (EMFs) and static magnetic field (SMF) have attracted interest for their effects on bone remodeling 18,19 and wound healing, [20][21][22] and have been used as adjuvant treatments for cartilage regeneration. [23][24][25][26][27][28][29][30][31] For example, EMFs apparently stimulated chondrocyte proliferation and proteoglycan synthesis in bovine and human cartilage cells.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of Chondrogenic Differentiation of Adult Human Bone Marrow-Derived Stromal Cells by a Moderate-Strength Static Magnetic Field

Amin

Brady

St-Pierre

et al. 2014

Tissue Engineering Part A

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Tissue-engineering strategies for the treatment of osteoarthritis would benefit from the ability to induce chondrogenesis in precursor cells. One such cell source is bone marrow-derived stromal cells (BMSCs). Here, we examined the effects of moderate-strength static magnetic fields (SMFs) on chondrogenic differentiation in human BMSCs in vitro. Cells were cultured in pellet form and exposed to several strengths of SMFs for various durations. mRNA transcript levels of the early chondrogenic transcription factor SOX9 and the late marker genes ACAN and COL2A1 were determined by reverse transcription-polymerase chain reaction, and production of the cartilage-specific macromolecules sGAG, collage type 2 (Col2), and proteoglycans was determined both biochemically and histologically. The role of the transforming growth factor (TGF)-β signaling pathway was also examined. Results showed that a 0.4 T magnetic field applied for 14 days elicited a strong chondrogenic differentiation response in cultured BMSCs, so long as TGF-β3 was also present, that is, a synergistic response of a SMF and TGF-β3 on BMSC chondrogenic differentiation was observed. Further, SMF alone caused TGF-β secretion in culture, and the effects of SMF could be abrogated by the TGF-β receptor blocker SB-431542. These data show that moderate-strength magnetic fields can induce chondrogenesis in BMSCs through a TGF-β-dependent pathway. This finding has potentially important applications in cartilage tissue-engineering strategies.

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The Influence of Permanent Magnetic Field Therapy on Wound Healing in Suction Lipectomy Patients: A Double-Blind Study

Cited by 50 publications

References 10 publications

Weak Power Frequency Magnetic Field Acting Similarly to EGF Stimulation, Induces Acute Activations of the EGFR Sensitive Actin Cytoskeleton Motility in Human Amniotic Cells

Weak Power Frequency Magnetic Field Acting Similarly to EGF Stimulation, Induces Acute Activations of the EGFR Sensitive Actin Cytoskeleton Motility in Human Amniotic Cells

Effect of static magnetic field on pain level and expression of P2X3 receptors in the trigeminal ganglion in mice following experimental tooth movement

Stimulation of Chondrogenic Differentiation of Adult Human Bone Marrow-Derived Stromal Cells by a Moderate-Strength Static Magnetic Field

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