The Influence of Perceived Social Support on Medication Adherence in First-Episode Psychosis

Rabinovitch, Mark A.; Cassidy, Clifford; Schmitz, N.; Joober, Ridha; Malla, Ashok

doi:10.1177/070674371305800111

Cited by 37 publications

(27 citation statements)

References 29 publications

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“…23,[48][49][50] A majority of studies also used a dichotomous subjective measure of adherence in the analysis, whereby an individual was considered nonadherent to medication when he or she reported taking less than 75% of the medication as prescribed. 21,41,[51][52][53][54] This has been shown to be comparable to the results of pill counting for FEP patients, although any subjective report tends to overestimate adherence to medication, as is the case in other psychiatric disorders. 55 The informers that tend to overestimate adherence the most are family members, followed by patients themselves and, to a much lesser extent, clinicians.…”

Section: Measures Of Adherencesupporting

confidence: 57%

Determinants of adherence to treatment in first-episode psychosis: a comprehensive review

Leclerc

Noto

Bressan

et al. 2015

Rev. Bras. Psiquiatr.

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Objective: To conduct a comprehensive review of current evidence on factors for nonadherence to treatment in individuals with first-episode psychosis (FEP). Methods: MEDLINE, LILACS, PsycINFO, and SciELO databases were searched with the keywords first episode psychosis, factor, adherence, nonadherence, engagement, disengagement, compliance, and intervention. References of selected studies were consulted for relevant articles. Results: A total of 157 articles were screened, of which 33 articles were retained for full review. The factors related to nonadherence were: a) patient-related (e.g., lower education level, persistent substance use, forensic history, unemployment, history of physical abuse); b) environment-related (e.g., no family involved in treatment, social adjustment difficulties); c) medication-related (e.g., rapid remission of negative symptoms when starting treatment, therapeutic alliance); and d) illness-related (e.g., more positive symptoms, more relapses). Treatment factors that improve adherence include a good therapeutic alliance and a voluntary first admission when hospitalization occurs. Conclusion:The results of this review suggest that nonadherence to treatment in FEP is multifactorial. Many of these factors are modifiable and can be specifically targeted in early intervention programs. Very few studies have assessed strategies to raise adherence in FEP.

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Section: Measures Of Adherencesupporting

confidence: 57%

Determinants of adherence to treatment in first-episode psychosis: a comprehensive review

Leclerc

Noto

Bressan

et al. 2015

Rev. Bras. Psiquiatr.

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“…Family members skeptical of medication and treatment may have a corrosive effect, 54 which in early illness appears dynamic, depending on contact and family function. 43 Consistent with this is the positive effect of family intervention on adherence and relapse in chronic illness, 2 even with 8 weeks of family psychoeducation. 88 5.…”

Section: Antipsychotic Formulation Long Acting Injectablementioning

confidence: 78%

“…[38][39][40][41] Information technology-based interventions are discussed below. Family support is important in young patients in first episode services, [42][43][44] but little other recent work specific to early schizophrenia focuses on setting, support, and adherence. 3.…”

Section: Antipsychotic Formulation Long Acting Injectablementioning

confidence: 99%

“…50,52 The timing of their "baseline" assessments may be critical for assessing their longitudinal effect because attitudes and adherence are dynamic in early psychosis. 5,20,43,46 Because variables directly predicting attitudes to medication in early psychosis appear to be fluid and so potentially amenable to change, it is worth considering what influences them:…”

Section: Antipsychotic Formulation Long Acting Injectablementioning

confidence: 99%

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Modeling Determinants of Medication Attitudes and Poor Adherence in Early Nonaffective Psychosis: Implications for Intervention

Drake

Nordentoft

Haddock

et al. 2015

Schizophrenia Bulletin

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We aimed to design a multimodal intervention to improve adherence following first episode psychosis, consistent with current evidence. Existing literature identified medication attitudes, insight, and characteristics of support as important determinants of adherence to medication: we examined medication attitudes, self-esteem, and insight in an early psychosis cohort better to understand their relationships. Existing longitudinal data from 309 patients with early Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, nonaffective psychosis (83% first episode) were analyzed to test the hypothesis that medication attitudes, while meaningfully different from "insight," correlated with insight and self-esteem, and change in each influenced the others. Rosenberg SelfEsteem Scale, Birchwood Insight Scale, and Positive and Negative Syndrome Scale insight were assessed at presentation, after 6 weeks and 3 and 18 months. Drug Attitudes Inventory (DAI) and treatment satisfaction were rated from 6 weeks onward. Structural equation models of their relationships were compared. Insight measures' and DAI's predictive validity were compared against relapse, readmission, and remission. Analysis found five latent constructs best fitted the data: medication attitudes, selfesteem, accepting need for treatment, self-rated insight, and objective insight. All were related and each affected the others as it changed, except self-esteem and medication attitudes. Low self-reported insight at presentation predicted readmission. Good 6-week insight (unlike drug attitudes) predicted remission. Literature review and data modeling indicated that a multimodal intervention using motivational interviewing, online psychoeducation, and SMS text medication reminders to enhance adherence without damaging self-concept was feasible and appropriate.

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“…During the study, a significant correlation was determined between monthly compliance percentage and means of familial support levels. No significant correlation was determined between social support and general compliance in all of the study period (55). Kelleci and Ata (56) investigated correlation between drug compliance and social support in psychiatry patients, and they reported statistically significant, positively directed weak correlation between friend support and drug compliance (57).…”

Section: Discussionmentioning

confidence: 99%

Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder

Aksoy¹,

Kelleci²

2016

Dusunen Adam

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Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder Objective: In bipolar disorder, recurrence rate is relatively high. With each episode, the risk of a new episode is increased. The first choice is drug treatment. However, patients have serious difficulties in drug compliance. This study was conducted to investigate drug compliance of patients with bipolar disorder, and to determine relationships between drug compliance, coping with stress, and social support. Method: The target population of the study included 280 patients registered in a state hospital with the diagnosis of bipolar disorder in 2011, residing in the city center, and having no other psychiatric disorders. Of these 280 patients, 150 who agreed to participate in the study and accepted to be visited at home after they were telephoned comprised the study sample. Of the patients in the target population, phone numbers and addresses were changed in 112 patients, and 18 refused to have a home-visit, so they were excluded from the study. Data were collected using the personal information form, Morisky Medication Adherence Scale, Multidimensional Scale of Perceived Social Support and Ways of Coping Scale. Results: In this study, it was determined that 55.3% of the patients did not comply with drug treatment. The patients with poor drug compliance preferred mainly desperate approach and submissive approach subdimensions of the Ways of Coping Scale more. There was no difference between patients with and without drug compliances in terms of social support. Conclusions: It is considered that development of effective coping strategies would promote drug compliance in patients with bipolar disorder. Keywords: Bipolar disorder, coping, medication compliance, nursing, social support ÖZET Bipolar hastalarda ilaç uyumunun stresle başetme ve sosyal destekle ilişkisi Amaç: Bipolar bozukluğun tekrarlama oranı oldukça yüksektir. Geçirilen her atak yeni bir atak geçirme riskini arttırır. Tedavide ilk seçenek ilaç tedavisidir. Ancak hastaların ilaç tedavisine uyumla ilgili ciddi sorunları bulunmaktadır. Bu çalışma bipolar hastaların ilaç uyumunu belirlemek, stresle başetme ve sosyal destekle ilişkisini incelemek amacı ile yapılmıştır. Yöntem: Araştırmanın evrenini bir devlet hastanesine 2011 yılında bipolar bozukluk tanısı ile kayıtlı olan, il merkezinde yaşayan, ek psikiyatrik tanısı olmayan 280 hasta, örneklemi ise telefonla aranarak araştırmaya katılmayı ve ev ziyaretini kabul eden 150 hasta oluşturdu. Evreni oluşturan hastalardan 112 kişiye telefon ve adres değişikliği, 18 kişiye ise ev ziyaretini kabul etmeme nedeni ile ulaşılamamıştır. Veriler, "Kişisel Bilgi Formu", "Morisky Uyum Ölçeği", "Çok Boyutlu Algılanan Sosyal Destek Ölçeği" ve "Stresle Başa Çıkma Tarzları Ölçeği" ile toplandı. İlaç uyumu iyi olan ve ilaç uyumu olmayan hastalar stresle baş etme biçimleri ve sosyal destek puanları açısından karşılaştırıldı. Bulgular: Çalışmada hastaların %55.3'ünün ilaç tedavisine uyumsuz olduğu belirlendi...

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The Influence of Perceived Social Support on Medication Adherence in First-Episode Psychosis

Cited by 37 publications

References 29 publications

Determinants of adherence to treatment in first-episode psychosis: a comprehensive review

Determinants of adherence to treatment in first-episode psychosis: a comprehensive review

Modeling Determinants of Medication Attitudes and Poor Adherence in Early Nonaffective Psychosis: Implications for Intervention

Relationship between drug compliance, coping with stress, and social support in patients with bipolar disorder

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