The influence of patient’s age on metabolic and bariatric results of laparoscopic sleeve gastrectomy in 2-year observation

Abstract

Background The incidence of obesity has been constantly growing and bariatric procedures are considered to be the most effective treatment solution for morbidly obese patients. The results of laparoscopic sleeve gastrectomy (LSG) may differ depending on patient’s age, gender, preoperative body mass index (BMI) and physical activity. Methods The aim of this study was to evaluate age-related differences in the outcome of LSG in terms of weight loss parameters, lipid and carbohydrate profile. The retrospective analysis of 555 patients who had undergone LSG was performed to compare the metabolic outcomes of surgery in individuals < 45 and ≥ 45 years old. Evaluation of weight loss parameters along with selected laboratory data was performed to demonstrate the results of LSG in 2 years follow-up. Results Overall, 238 males and 317 females (43%/57%) with median age of 43 years and median preoperative BMI of 46.41 (42.06–51.02) kg/m2 were analyzed. Patients in both groups presented significant weight loss at 24 months after the surgery with comparable percentage of total weight loss (40.95% in < 45 years old group and 40.44% in ≥ 45 years old group). The percentage of excess weight loss (78.52% vs. 74.53%) and percentage of excess BMI loss (91.95% vs. 88.01%) were higher in patients < 45 years old. However, the differences were not statistically significant (p = 0.662, p = 0.788 respectively). Patients under 45 years old experienced faster decrease in fasting glucose level that was observed after only 3 months (109 mg/dl to 95 mg/dl in < 45 years old group vs. 103.5 mg/dl to 99.5 mg/dl in ≥ 45 years old group, p < 0.001). Both groups presented improvement of lipid parameters during the observation. However, patients < 45 years old achieved lower values of LDL at 3 and 12 months follow-up (115 mg/dl vs. 126 mg/dl, p = 0.010; 114.8 mg/dl vs. 122 mg/dl, p = 0.002). Younger group of patients also showed superior improvement of triglycerides level. Conclusions LSG results in significant weight loss in all patients regardless age. In turn, superior and faster improvement in lipid and carbohydrate profile is achieved in patients under 45 years old.

Enhanced Patient Portal Engagement Associated with Improved Weight Loss Outcomes in Post-Bariatric Surgery Patients

“…This could be attributed to faster metabolic rates in younger individuals. [41] Our findings align with prior studies that reported racial differences in weight loss after bariatric surgery, noting that self-identified Black patients experienced less weight loss compared to their White counterparts; however, the underlying causative reasons remain unclear. [42] We also found that patients with multiple comorbidities exhibited less weight loss, highlighting the needs for tailored postoperative care for patients with more complex health conditions.…”

One‐year outcomes of laparoscopic sleeve gastrectomy in morbidly obese patients regarding the age, gender, and postoperative follow‐ups

“…As opposed to these studies, Woźniewska et al in a very recent study in Poland showed significant weight loss in all patients to be independent of age and all individuals (<45 and ≥45 years old) presented significant weight loss at 24 months after the surgery. However, the improvement in lipid and carbohydrate profile was rather faster and stronger in the older group compared to younger patients 31 …”

“…However, the improvement in lipid and carbohydrate profile was rather faster and stronger in the older group compared to younger patients. 31 The safety and effectiveness of LSG were frequently demonstrated in different studies [32][33][34][35][36] ; however, some studies observed the severity of complications to be higher after LSG than other bariatric procedures. [37][38][39] In conclusion, this study further supports the evidence of LSG being an effective technique for substantial and sustainable weight loss in morbidly obese patients.…”

Bariatric surgery and menopause

“…%EWL was found to be higher in the younger group. The younger group also had more rapid normalization of fasting glucose levels after 3 months of observation (109 down to 95 mg/dl vs. 103.5 vs. 99.5 mg/dl, p < 0.01) and lower values of low-density lipoprotein serum levels at 3 months (115 vs. 126 mg/dl, p < 0.01) and 12 months (114.8 vs. 122 mg/dl, p < 0.01) of follow-up, as well as a more significant decrease of triglyceride serum levels [ 12 ].…”