The influence of pancreas-derived stem cells on scaffold based skin regeneration

Salem, Haitham; Ciba, P.; Rapoport, Daniel H.; Egaña, José Tomás; Reithmayer, K.; Kadry, M.; Machens, H.G.; Kruse, Charli

doi:10.1016/j.biomaterials.2008.10.050

Cited by 23 publications

(16 citation statements)

References 34 publications

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“…4). This data was partially and recently described [8]. However, in this work, the use of a highly degradable scaffold (MatridermÔ), and the presence of subcutaneous vascularized tissue do not allow obtaining such conclusions with a transillumination method.…”

Section: Discussioncontrasting

confidence: 54%

“…Previously, we described gland-derived stem cells as adult pluripotent stem cells that can spontaneously differentiate into multiple cell lineages [7]. Moreover, we had recently shown that stem cells derived from rat pancreas can be used to improve both, epidermalization and vascularization in skin regeneration [8]. Here we extend these data to other glands, emphasizing in their possible mechanisms of contribution, showing for the first time the therapeutic potential of pancreatic stem cells (PSC) and submandibular stem cells (SSC), showing their potential to enhance vascular regeneration and elucidating the possible cellular and molecular mechanisms behind the therapeutic effects of these newly described stem cell populations.…”

Section: Introductionmentioning

confidence: 98%

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The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration

Egaña¹,

Danner²,

Kremer³

et al. 2009

Biomaterials

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 98%

The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration

Egaña¹,

Danner²,

Kremer³

et al. 2009

Biomaterials

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“…It found up to a 100% healing rate for CCHL in a 2-week period. Previous studies mentioned nearly the same percentages of healing with pancreas-derived stem cells on scaffold, but this was not infection wounds (Salem et al, 2009). In general, the results suggested that CCHL was a promising dressing for MRSA infected burn wounds, although in our studies there were not sufficient positive controls such as bactroban, silver sulfadizine, and others.…”

Section: Discussioncontrasting

confidence: 41%

Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillin-resistant Staphylococcus aureus and promotion wound healing properties

Cui¹,

Li²,

Huang³

et al. 2010

Drug Delivery

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“…ADSCs secrete various growth factors that control and regenerate damaged skin-type cells, a function that has been termed essential for the regenerative mechanisms of ADSCs [224]. Salem et al seeded pancreatic stem cells (PSCs) on "matriderm" and used the matrix to replace the bilateral full-thickness skin wounds made on the dorsum of Nu/Nu nude mice [225]. The vascularization rate showed a significant increase in the PSC-seeded scaffolds, and the morphology and immunohistochemistry showed new skin-like structures positive to epidermal markers of healing wound.…”

Section: Stem Cell-scaffold Constructs For Skin Tissue Engineeringmentioning

confidence: 99%

Stem Cells and Nanostructures for Advanced Tissue Regeneration

Prabhakaran

Venugopal

Ghasemi‐Mobarakeh

et al. 2011

Biomedical Applications of Polymeric Nanofibers

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Stem cells are a promising alternative for cell therapy applications because of their self-renewing capability and potential to differentiate into a wide range of specialized cell lineages, including osteoblasts, chondrocytes, cardiomyocytes, and neuronal cells. Different kinds of stem cells are considered for cell-based tissue engineering approaches, of which bone-marrow-derived mesenchymal stem cells (BM-MSCs), adipose-derived stem cells (ADSCs) and embryonic stem cells (ESCs) are frequently utilized for advancement of new tissue engineering strategies. Nanostructures created by natural, synthetic, or composite polymeric biomaterials provide artificial templates of the extracellular matrix (ECM). They possess a high surface area to volume ratio, are porous with good mechanical properties, are sufficient to serve as a biomimetic platform to attract stem cells, cause differentiation, and provide functioning of the tissues. Nanoscale features such as fibers, pits, and grooves modulate cell behavior and might even stimulate the differentiation of stem cells to specific lineages; for example, the nanotopographical cues combined with chemical cues influence the neuronal induction of MSCs, resulting in high microtubule-associated protein expressions. Scaffolds can also be impregnated with several ligands for adhesion of receptors to the cells, or with other regulatory molecules and growth M.P. Prabhakaran (*) and J. Venugopal E3-05-12, Health Care and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore e-mail: nnimpp@nus.edu.sg L. Ghasemi-Mobarakeh Islamic Azad University, Najafabad Branch, Isfahan, Iran D. Kai NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore G. Jin and S. Ramakrishna Department of Mechanical Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore factors for designed cell behavior or controlled cell differentiations. Different polymeric blends or fibers incorporated with nanoparticles (such as hydroxyapatite) in aligned or custom-made patterns can induce specific differentiation of stem cells for bone, cartilage, cardiac, nerve, and skin tissue regeneration. In this review, we will discuss the current state of the art and future perspectives on stem cells and their differentiation on nanoengineered substrates for advanced tissue regeneration.

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The influence of pancreas-derived stem cells on scaffold based skin regeneration

Cited by 23 publications

References 34 publications

The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration

The use of glandular-derived stem cells to improve vascularization in scaffold-mediated dermal regeneration

Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillin-resistant Staphylococcus aureus and promotion wound healing properties

Stem Cells and Nanostructures for Advanced Tissue Regeneration

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