The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs

Debackere, M.; Landuyt, José; Vercruysse, Jozef; McKellar, Quintin

doi:10.1111/j.1365-2885.1993.tb00173.x

Cited by 16 publications

(8 citation statements)

References 15 publications

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“…These results are similar to those that have been observed in other animals (Baert et al, 1993;Debackere et al, 1993;Ben-Zvi et al, 1996).…”

Section: Discussionsupporting

confidence: 92%

“…In the present research, we examined the pharmacokinetics of febantel after oral administration to healthy tiger puffer, in order to determine if the drug is also metabolized to fenbendazole in tiger puffer as in other animals (Baert et al, 1993;Debackere et al, 1993;BenZvi et al, 1996), and also if febantel, more specifically fenbendazole, is absorbed into blood of the host. We also report the potentially significant anti-H. okamotoi activity of febantel in both tiger puffer experimentally infected and those naturally infected with this parasite.…”

mentioning

confidence: 99%

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Efficacy of Orally Administered Febantel against Monogenean Heterobothrium okamotoi infection of Cultured Tiger Puffer Takifugu rubripes

武志¹,

守²,

昌功

et al. 2006

Fish Pathol.

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ABSTRACT-We examined the efficacy of febantel against the infection of the diclidophorid monogenean Heterobothrium okamotoi in cultured tiger puffer Takifugu rubripes. Febantel is a prodrug of fenbendazole, a benzimidazole drug, which is widely used in the field of veterinary medicine. Febantel was metabolized to fenbendazole in tiger puffer just like veterinary animals for oral administration. At the doses of 12.5 mg/kg and 25 mg/kg for 5 days, and 50 mg/kg for 3 days, 88%, 96% and 94%, respectively, of mature worms, and 97%, 95% and 97%, respectively, of immature worms were eradicated at 22-23∞C. These results suggest that febantel has high anti-H. okamotoi activity.

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“…These results are similar to those that have been observed in other animals (Baert et al, 1993;Debackere et al, 1993;Ben-Zvi et al, 1996).…”

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Efficacy of Orally Administered Febantel against Monogenean Heterobothrium okamotoi infection of Cultured Tiger Puffer Takifugu rubripes

武志¹,

守²,

昌功

et al. 2006

Fish Pathol.

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show abstract

“…This concentration was at least 10 times lower than those of the febantel metabolites (Debackere et al 1993). However, it seems that it is mainly taken up via the surface, at least when it is given as a single drug.…”

Section: Discussionmentioning

confidence: 93%

Effects of the synergistic action of febantel and pyrantel on the nematode Heterakis spumosa : a light and transmission electron microscopy study

Mehlhorn

Harder

1997

Parasitology Research

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The present study proved that combined administration of pyrantel and febantel to Heterakis spumosa-infected mice yielded clear synergistic effects (seen in a quicker expulsion of the worms and a significant higher degree of worm degeneration), whereas the different doses of both drugs never reached the same efficacy, when given alone. It is concluded that the synergistic action of pyrantel and febantel on the functions of different organs of the parasites (muscle, nerve, inertine etc.) seen in the rodent model - also holds for the gut dwelling nematodes of the dog.

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“…Kidney deficiency may hinder drug excretion (Guerrini et al, 1984;Terao & Shen, 1984). Gastrointestinal diseases may decrease the rate and extent of absorption of drugs administered orally (van Gogh et al, 1984;Debackere et al, 1993). Diseases of the heart and circulatory system may influence the distribution of drugs in the body (Benowitz & Meister, 1976;Sweeney et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of ampicillin and sulfadimidine in pigs infected experimentally with Streptococcus suum

Yuan

Miao

Yin

1997

Vet Pharm & Therapeutics

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Twenty-three hybrid pigs (23 +/- 3 kg body wt) were assigned to three groups to investigate the pharmacokinetics of ampicillin (APC, 10 mg/kg) administered intravenously (i.v.) and intramuscularly (i.m.), and sulfadimidine (SDM, 50 mg/kg) administered intravenously as a bolus injection. In the first series of experiments the animals remained healthy. Subsequently, the pigs were infected with Streptococcus suum by subcutaneous (s.c.) inoculation and the experiments were repeated. The total apparent distribution volume of APC given intravenously was increased from 0.512 +/- 0.026 L/kg in uninfected pigs to 0.68 +/- 0.06 L/kg (P < 0.01) in infected pigs, whereas there were no significant changes in the same parameter for SDM (P > 0.05). The clearance of APC was increased markedly from 0.52 +/- 0.07 L/kg/h in uninfected pigs to 0.62 +/- 0.10 L/kg/h in infected pigs. In contrast, SDM clearance was decreased markedly from 0.023 +/- 0.003 L/kg/h to 0.017 +/- 0.003 L/kg/h (P < 0.05). As a result, the biological half-lives of the drugs were altered to varying degrees in infected pigs. The half-life of SDM was increased from 15.0 +/- 3.0 h in uninfected pigs to 20 +/- 7h in infected pigs (P < 0.05), but differences in APC half-lives between uninfected and infected animals were not observed (P > 0.05). There were no statistically significant differences in pharmacokinetic parameters of APC administered by intramuscular injection between the healthy and the diseased status, although its half-life was shortened from 0.76 +/- 0.22 h in the healthy to 0.57 +/- 0.23 h in the diseased. The results suggest that blood concentrations of APC and SDM are affected differently by the same disease due to its specific effects on their distribution and elimination.

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The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs

Cited by 16 publications

References 15 publications

Efficacy of Orally Administered Febantel against Monogenean Heterobothrium okamotoi infection of Cultured Tiger Puffer Takifugu rubripes

Efficacy of Orally Administered Febantel against Monogenean Heterobothrium okamotoi infection of Cultured Tiger Puffer Takifugu rubripes

Effects of the synergistic action of febantel and pyrantel on the nematode Heterakis spumosa : a light and transmission electron microscopy study

Pharmacokinetics of ampicillin and sulfadimidine in pigs infected experimentally with Streptococcus suum

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