The influence of omega-3 supplementation on vitamin D levels in humans: a systematic review and dose-response meta-analysis of randomized controlled trials

Alhabeeb, Habeeb; Kord‐Varkaneh, Hamed; Tan, Shing Cheng; Găman, Mihnea‐Alexandru; Otayf, Bander Yayha; Qadri, Almuhannad; Alomar, Osama; Salem, Hany; Al‐Badawi, Ismail A.; Abu‐Zaid, Ahmed

doi:10.1080/10408398.2020.1863905

Cited by 7 publications

(2 citation statements)

References 51 publications

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“…In another study, researchers concluded that severe VitD deficiency in healthy children caused deterioration of T/DS homeostasis together with increased protein oxidation and that this situation could not be successfully treated with external VitD supplementation [ 11 ]. In a meta-analysis of randomized controlled trials evaluated by Alhabeeb et al, omega-3 supplementation was shown to increase 25 (OH)D concentration [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing Oxidative Stress by Thiol/Disulfide Homeostasis Among Vitamin D-Deficient Patients

Gemcioğlu¹,

Başer²,

Çakmak³

et al. 2021

Cureus

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Objective: Thiol/disulfide (T/DS) homeostasis represents a promising new approach to evaluate oxidative stress. Therefore, we aimed to examine T/DS homeostasis in vitamin D (VitD)-deficient patients.Methods: We enrolled 154 patients with VitD deficiency and 154 healthy control subjects in the study. For both groups, native thiol, total thiol, and disulfide values were measured. Additionally, considering the obtained 25-hydroxycholecalciferol [25(OH)D] levels, the patient group was further divided into two subgroups (Group 1: <10 ng/mL, Group 2: 10-20 ng/mL), which were compared in more depth according to the specified parameters.Results: Values of native thiol, total thiol, and disulfide measured in the combination of Groups 1 and 2, comprising individuals with VitD deficiency, proved to be higher in comparison to the control group with statistical significance (p=0.007, p=0.028, and p<0.001, respectively). When subgroups were considered according to VitD classifications, native thiol and total thiol were again higher in Group 1 in comparison to the values obtained for control subjects (p=0.022; p<0.001). While the total thiol level of Group 2 was higher than that of controls (p<0.001), no difference with statistical significance was obtained in the comparison of disulfide levels among the indviduals of Group 1, Group 2, and the controls (p=0.081). Conclusion:In this study, among patients with VitD deficiency, we have confirmed that values of native thiol and total thiol were increased, while the T/DS balance was found to have shifted in favor of the thiol level.

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Section: Discussionmentioning

confidence: 99%

Assessing Oxidative Stress by Thiol/Disulfide Homeostasis Among Vitamin D-Deficient Patients

Gemcioğlu¹,

Başer²,

Çakmak³

et al. 2021

Cureus

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“…11,[46][47][48][49] Vitamin D levels can be modulated by consuming other drugs/supplements, eg, omega-3 fatty acids. 50 Thus, there have been recommendations that taking vitamin supplements may potentially contribute to NAFLD treatment. However, the results are inconsistent.…”

mentioning

confidence: 99%

The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study

Xing¹,

Tien²,

Zhou³

et al. 2022

DMSO

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To investigate the association between vitamin D deficiency and NAFLD risk in patients with type 2 diabetes mellitus (T2DM). Methods: Overall, 434 patients with T2DM admitted to Hebei General Hospital from January 2019 to December 2019 were selected as the study subjects. According to abdominal ultrasound findings, patients were divided into the NAFLD group and the non-NAFLD group. Participants were divided into two study groups according to the 25-hydroxyvitamin D [25(OH)D] level. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were <20 ng/mL. Chi-square test and one-way analysis of variance were used to compare groups. The relationship between 25(OH)D and NAFLD risk was analyzed using correlation and regression analyses. Furthermore, subgroup analyses were performed to verify the robustness of the results. Results:The 25(OH)D level in patients with T2DM complicated by NAFLD was significantly lower than in patients with T2DM only. Vitamin D deficiency was highly prevalent among T2DM patients with NAFLD. This study suggested that vitamin D deficiency was an independent factor for developing NAFLD in patients with T2DM. T2DM patients with vitamin D deficiency had 2.045 times higher risk of developing NAFLD than those without vitamin D deficiency. Vitamin D deficiency was associated with high NAFLD preference in T2DM patients with BMI >23kg/m 2 , but not those with BMI ≤23kg/m 2 . The significant correlation between vitamin D deficiency and NAFLD was found in participants with BMI >23kg/m 2 , age ≤65 years, without hypertension, TG <1.7mmol/l, HDL ≥1 mmol/l in men, ≥1.3 mmol/l in women, HBA1C ≤7%, or females. Conclusion:This study suggests that T2DM people with BMI >23kg/m 2 were more susceptible to NAFLD by vitamin D deficiency and that it is necessary to maintain optimal serum vitamin D levels in this population.

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The Effects of Vitamin D on Markers of Glucose and Obesity in Postmenopausal Women: A Meta-analysis of Randomized Controlled Trials

Hao,

Lu,

Gao

et al. 2023

Clinical Therapeutics

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The influence of omega-3 supplementation on vitamin D levels in humans: a systematic review and dose-response meta-analysis of randomized controlled trials

Cited by 7 publications

References 51 publications

Assessing Oxidative Stress by Thiol/Disulfide Homeostasis Among Vitamin D-Deficient Patients

Assessing Oxidative Stress by Thiol/Disulfide Homeostasis Among Vitamin D-Deficient Patients

The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study

The Effects of Vitamin D on Markers of Glucose and Obesity in Postmenopausal Women: A Meta-analysis of Randomized Controlled Trials

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