The influence of olfactory dysfunction on risk of malnutrition is mediated by depressive symptoms in cancer patients undergoing chemotherapy

Lin, Yanfeng; Jiang, Xiaocong; Huang, Xinmei; Lv, Yifan

doi:10.21037/apm-21-2221

Cited by 2 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than 50% of patients with gastric cancer are in a state of malnutrition after surgery, and their average weight decreases by 10-20% (4). In addition, chemotherapy leads to severe gastrointestinal reactions and immunosuppression, also affecting nutritional status (5,6). From the perspective of pathophysiology, the nutritional status of patients is closely associated with material metabolism, the functional operation of important organs, the immune response, and cell membrane stability.…”

Section: Introductionmentioning

confidence: 99%

Construction and validation of a predictive model for the risk of three-month-postoperative malnutrition in patients with gastric cancer: a retrospective case-control study

Tian¹,

Wu²,

Tang³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

Background: This study analyzed both the influencing factors of malnutrition in patients with gastric cancer and established a multi-dimensional risk model to predict postoperative malnutrition three months after surgery. Methods:The clinical data of gastric cancer patients hospitalized for the first time and receiving laparoscopic surgery in the general surgery department of our hospital were retrospectively analyzed through the hospital information system and divided into a training set and a validation set in the ratio of 7:3. Nutritional status was assessed using the Patient Generated Subjective Global Assessment scale and follow-up records three months after surgery. Patients were divided into a non-malnutrition group and a malnutrition group, and a risk prediction model was established and displayed in the form of a nomogram. Results: A total of 344 patients were included, with 242 in the training and 102 in the validation set. Tumor node metastasis stage (TNM Stage, P=0.020), cardiac function grading (CFG, P=0.013), prealbumin (PAB, P<0.001), neutrophil-to-lymphocyte ratio (NLR, P=0.027), and enteral nutrition within 48 hours post-operation (EN 48h post-op, P=0.025) were independent risk factors. We established a prediction model with the above variables and displayed it via a nomogram, then verified its effectiveness through internal and external verification. This revealed a C-index of 0.84 (95% CI: 0.79-0.89), and the area under curve (AUC) areas of 0.840 (training set) and 0.854 (validation set), which was better than the nutritional risk screening 2002 (NRS2002) scale. The calibration curve brier scores were 0.159 and 0.195, and the Hosmer-Lemeshow test chi-square values were 14.070 and 1.989 (P>0.05). The decision curve analysis (DCA) of the training set model indicated the clinical applicability was good and within the threshold probability range of 10%-85%, which was also better than NRS2002. Conclusions: A clinical prediction model including multi-dimensional variables was established based on independent risk factors of malnutrition three months after gastrectomy in patients with gastric cancer. The model yields greater prediction accuracy of the risk of three-month-postoperative malnutrition in patients with gastric cancer, helps screen high-risk patients, formulates targeted nutritional prescriptions early, and improves the overall prognosis of patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Construction and validation of a predictive model for the risk of three-month-postoperative malnutrition in patients with gastric cancer: a retrospective case-control study

Tian¹,

Wu²,

Tang³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…Other important functions of olfaction relate to maintaining proper nutrition status, sensation of pleasure, and interpersonal behavior 6 . The olfactory impairment will therefore result in deterioration of social life and higher risk of depression 3–10 . The olfactory dysfunctions are also considered as an early biomarker in neurodegenerative disorders and as a negative prognostic factor of the 5‐year mortality in older adults 11,12 .…”

Section: Introductionmentioning

confidence: 99%

“… 6 The olfactory impairment will therefore result in deterioration of social life and higher risk of depression. 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 The olfactory dysfunctions are also considered as an early biomarker in neurodegenerative disorders and as a negative prognostic factor of the 5‐year mortality in older adults. 11 , 12 Nasal cavity obstruction due to chronic rhinosinusitis is one of the most common cause for the olfactory dysfunction together with others nasal cavity pathologies like allergic rhinitis, septal deviation with hypertrophic mucosal changes.…”

Section: Introductionmentioning

confidence: 99%

Reliability and validity of the Polish version of the Questionnaire of Olfactory Disorders

Tuz-Hrycyna

Rzepakowska

Niemczyk

2023

Laryngoscope Investig Oto

View full text Add to dashboard Cite

BackgroundThe comprehensive counseling of patients with olfactory dysfunctions requires accurate diagnosis. The recommendations include subjective assessment. The Questionnaire of Olfactory Disorders (QOD) is a disease‐specific questionnaire for the subjective evaluation of olfactory dysfunctions.MaterialThe study included 54 patients with olfactory dysfunctions, who were recruited to the study group (SG). The other 47 patients without the history of olfactory dysfunction and nasal cavity pathology were voluntarily allocated to the control group (CG). The protocol of the study was introduced to each patient and included: olfactory testing with Sniffin' Stick test, fulfillment of the Polish version of World Health Organization Quality of Life brief questionnaire and completing of the Polish version of the QOD. All participants (101) were invited for refilling the QOD questionnaire after 2 weeks for the test–retest statistics.ResultsThe Polish QOD statements were significantly correlated and met the requirement by having test–retest correlation larger than 0.7. We found that internal consistency of the test measured by Cronbach's alpha coefficient was very high. The mean scores of the QOD test in normosmic SG patients were compared with corresponding scores in normosmic CG patients using U Mann–Whitney test. The analysis revealed statistically significant differences on mean QOD scores for each domains except QOD‐S between both groups.ConclusionsThe Polish version of the QOD demonstrated high rate of the validity and the reliability. This instrument may be widely used in research projects and clinical practice concerning olfactory disorders in Polish patients.Level of EvidenceNA.

show abstract

The influence of olfactory dysfunction on risk of malnutrition is mediated by depressive symptoms in cancer patients undergoing chemotherapy

Cited by 2 publications

References 19 publications

Construction and validation of a predictive model for the risk of three-month-postoperative malnutrition in patients with gastric cancer: a retrospective case-control study

Construction and validation of a predictive model for the risk of three-month-postoperative malnutrition in patients with gastric cancer: a retrospective case-control study

Reliability and validity of the Polish version of the Questionnaire of Olfactory Disorders

Contact Info

Product

Resources

About