The Influence of Oily Vehicle Composition and Vehicle-Membrane Interactions on the Diffusion of Model Permeants across Barrier Membranes

Najib, Omaima N.; Martin, Gary P.; Kirton, Stewart B.; Botha, Michelle; Sallam, Al Sayed; Murnane, Darragh

doi:10.3390/membranes11010057

Cited by 4 publications

(3 citation statements)

References 27 publications

(42 reference statements)

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“…For transdermal diffusion, attempts have been made to create synthetic membranes to be used as human skin models for pharmaceutical and cosmetic formulations [5]. Recently, great effort has been put into developing artificial membranes as surrogates for human skin [18,19]. However, additional efforts must be made to mimic the complex composition of the lipid structure of the SC [20].…”

Section: Introductionmentioning

confidence: 99%

A Synthetic Model of the Mucosa for Oral Penetration Studies

Alonso,

Martí,

Ramos

et al. 2023

Membranes

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The main objective of this study is the evaluation of the use of a synthetic membrane, Nuclepore, as a model for permeation studies through sublingual mucosa. The permeability of two types of membranes, porcine sublingual oral mucosa and a synthetic Nuclepore membrane, to water was compared. Moreover, the water permeability of membranes modified with waterproofing formulations was measured to study their ability to protect against the penetration of viruses, toxins, etc. A relatively high correlation (R2 0.88) was obtained between the transmucosal water loss (TMWL) values of the artificial membrane and the mucosa. These results support the possible use of this synthetic membrane in the screening of the water permeability of formulations. In addition, studies of the permeation of different actives, drugs, and biocides through the two membranes were carried out, and these results were compared with their skin permeation data. The synthetic membrane does not seem to discern between compounds in terms of permeability. However, the permeation of caffeine through intact or modified membranes incorporating waterproofing formulations presents similar permeation profiles through the synthetic membrane and mucosa. The results from these assays should lend support to the use of this synthetic membrane when screening formulations to be applied in oral penetration studies.

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Section: Introductionmentioning

confidence: 99%

A Synthetic Model of the Mucosa for Oral Penetration Studies

Alonso,

Martí,

Ramos

et al. 2023

Membranes

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“…Additionally, attempts have been made to create synthetic membranes that can be used as human skin models to investigate the transdermal diffusion properties of pharmaceutical and cosmetic formulations [7]. Recently, great effort has been put into developing artificial Membranes 2021, 11, 444 2 of 14 membranes as surrogates for human skin [8,9]. Such synthetic membranes are made up of a thin film of polymeric macromolecules that can content the transfer of components through them.…”

Section: Introductionmentioning

confidence: 99%

Lanolin-Based Synthetic Membranes for Transdermal Permeation and Penetration Drug Delivery Assays

et al. 2021

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Due to the high similarity in composition and structure between lanolin and human SC lipids, we will work with two models from wool wax. Two types of lanolin were evaluated: one extracted with water and surfactants (WEL) and the other extracted with organic solvents (SEL). Skin permeation and skin penetration studies were performed with two active compounds to study the feasibility of the use of lanolin-based synthetic membranes as models of mammalian skin. Diclofenac sodium and lidocaine were selected as the active compounds considering that they have different chemical natures and different lipophilicities. In the permeation assay with SEL, a better correlation was obtained with the less permeable compound diclofenac sodium. This assay suggests the feasibility of using artificial membranes with SEL as a model for percutaneous absorption studies, even though the lipophilic barrier should be improved. Penetration profiles of the APIs through the SEL and WEL membranes indicated that the two membranes diminish penetration and can be considered good membrane surrogates for skin permeability studies. However, the WEL membranes, with a pH value similar to that of the skin surface, promoted a higher degree of diminution of the permeability of the two drugs, similar to those found for the skin.

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“…The linking of optical microscopy and computational microscopy (MD simulation) is particularly effective when studying the mechanisms of lipid conformation dynamics, nanodomain formation, phase separation, and membrane homeostasis. Another interesting study is that of Najib et al [2] who focused on issues concerning lipid vehicles and their interactions with membranes. They investigated the uptake of different oily vehicles and blends of oils into silicone membrane and its effect on the diffusion of model permeants.…”

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confidence: 99%