The influence of occupational chronic lead exposure on the levels of selected pro-inflammatory cytokines and angiogenic factors

Machoń-Grecka, Anna; Dobrakowski, Michał; Boroń, Marta; Lisowska, Grażyna; Kasperczyk, Aleksandra; Kasperczyk, Sławomir

doi:10.1177/0960327117703688

Cited by 23 publications

(16 citation statements)

References 41 publications

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“…Lead damages many tissues through the induction of oxidative stress [ 26 , 57 ], leading to lipid peroxidation, which induces inflammatory processes [ 58 ]. Moreover, occupational exposure of humans to lead increases serum levels of some pro-inflammatory cytokines [ 59 ] such as IL-1, IL-6, and TNF- α [ 60 ]. TNF-α is produced at the site of inflammation by activated macrophages and lymphocytes and participates with IL-1β and IL-6 to induce systemic inflammatory reactions [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Effects of Azolla pinnata Ethanolic Extract against Lead-Induced Hepatotoxicity in Rats

et al. 2020

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The current study investigated the protective potential of Azolla pinnate ethanolic extract (APE) against lead-induced hepatotoxicity in rats. Sixty male Wistar albino rats were randomly allocated into six groups (n = 10). The control group was orally administrated with saline. The second group received lead acetate (100 mg/kg body weight (BW) orally for 60 days). The third group was fed with APE (10 mg/kg BW orally for 60 days). The fourth group was administrated with lead acetate like the second group and APE like the third group, concomitantly, for 60 days. The fifth group was administrated with APE like the third group for 30 days, then orally administrated with the lead acetate like the second group for another 30 days. The sixth group was administrated with lead acetate like the second group for 30 days, then with APE like the third group for a further 30 days. Phytochemical analysis of APE indicated the presence of peonidin 3-O-glucoside cation, vitexin, rutin, thiamine, choline, tamarixetin, hyperoside, astragalin, and quercetin. The latter has been elucidated using one- and two-dimensional nuclear magnetic resonance (1D and 2D NMR) and liquid chromatography–mass spectrometry (LC–MS-MS). Lead acetate increased the serum levels of alanine and aspartate aminotransferases and that of urea, creatinine, tumor necrosis factor alpha, and interleukin 1β, hepatic tissue malondialdehyde contents, and caspase 3 protein expression, as well as altering the hepatic tissue architecture. However, it decreased the serum levels of interleukin 10 and glutathione (GSH) contents, and the activities of catalase and superoxide dismutase in hepatic tissue. In contrast, the administration of APE ameliorated the lead-induced alterations in liver function and structure, exemplifying the benefits of Azolla’s phytochemical contents. Collectively, A. pinnate extract is a protective and curative agent against lead-induced hepatotoxicity via its antioxidant, anti-inflammatory, and anti-apoptotic impacts.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Effects of Azolla pinnata Ethanolic Extract against Lead-Induced Hepatotoxicity in Rats

et al. 2020

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“…Lead poisoning is a worldwide public health hazard and several studies have indicated the deleterious effects of Pb on kidney and testis 12 , 17 . Studies in humans have shown that high blood Pb level increases the risk of developing kidney diseases by affecting transportation in proximal tubules and diminishing creatinine clearance 14 .…”

Section: Discussionmentioning

confidence: 99%

“…The metal also inhibits cellular energy production and induces apoptosis subsequent to mitochondrial impairment and DNA damage 9 , 10 . Additionally, Pb simultaneously upregulates and inhibits the production of several pro- and anti-inflammatory cytokines 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats

BaSalamah

Abdelghany

El‐Boshy

et al. 2018

Sci Rep

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This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative control, for four weeks with lead acetate in drinking water (1,000 mg/L) and/or intramuscular VD (1,000 IU/kg; 3 days/week). Pb toxicity markedly reduced serum VD and Ca2+, induced substantial renal and testicular injuries with concomitant significant alterations in the expression of VD metabolising enzymes, its receptor and binding protein, and the calcium sensing receptor. Pb also significantly promoted lipid peroxidation and pro-inflammatory cytokines (IL-4 and TNF-α) in the organs of interest concomitantly with declines in several anti-oxidative markers (glutathione, glutathione peroxidase and catalase) and the anti-inflammatory cytokine, IL-10. The co-administration of VD with Pb markedly mitigated renal and testicular injuries compared with positive controls. This was associated with restoration of the expression of VD related molecules, promotion of anti-oxidative and anti-inflammatory markers, but tissue Pb concentrations were unaffected. In conclusion, this report is the first to reveal potential protective effects for VD against Pb-induced renal and testicular injuries via anti-inflammatory and anti-oxidative mechanisms.

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“…Similar results were obtained in lead recycling plant workers (BLL =30.7 μg/d l ), who exhibited significantly higher TNF-α than controls 19) . Our previous study on chronically Pb exposed workers (BLL=37.0 μg/d l ) demonstrated not only higher levels of TNF-α, but also higher levels of IL-6 and IL-1β 14) .…”

Section: Discussionmentioning

confidence: 80%

“…Furthermore, in vitro studies indicate the influence of Pb on growth and tube formation by cultured human umbilical vascular endothelial cells (HUVEC) 12 , 13) . It has been postulated that Pb promotes inflammatory processes via induction of the pro-inflammatory cytokines and modulates angiogenesis in chronically occupational lead exposed workers 14) . However, there are no studies on the relationship between other parameters of the immune response and angiogenic factors during short-term lead exposure.…”

Section: Introductionmentioning

confidence: 99%

The effect of subacute lead exposure on selected blood inflammatory biomarkers and angiogenetic factors

Machoń-Grecka

Dobrakowski

Kasperczyk

et al. 2018

Journal of Occupational Health

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Objectives: The aim of the study was to examine blood levels of selected pro-inflammatory cytokines, C reactive protein (CRP), and selected factors that influence angiogenesis in workers exposed to lead for a short period of time. Methods: The study population consisted of 36 male workers (mean age 41 ± 14 years) exposed to lead for 40 days. Results: The mean blood lead level (BLL) was 10.7 ± 7.67 μg/dl at the beginning of the study, and increased to 49.1 ± 14.1 μg/dl at the end of the study period. The levels of macrophage inflammatory protein 1-α (MIP-1α) were significantly higher after the studied exposure to lead compared to the baseline by 71%. Similarly, the values of CRP increased by 35%. Conversely, the values of soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and fibroblast growth factor-basic (FGF-basic) decreased by 14% and 21%, respectively. After the examined period of lead exposure, analysis of correlations showed positive correlations between vascular endothelial growth factor (VEGF) levels and the levels of interleukin 1β (IL-1β) (R = 0.39), interleukin 6 (IL-6) (R = 0.42), and MIP-1α (R = 0.54). Positive correlations were identified between MIP-1α and FGF-basic (R = 0.38), soluble angiopoietin receptor (sTie-2) (R = 0.41), and sVEGFR-1 (R = 0.47). Discussion: Short-term exposure to lead induces the inflammatory response; however, these mechanisms seem to be different from those observed in chronic lead exposure. Subacute exposure to lead may dysregulate angiogenesis via modifications in the levels of angiogenic factors.

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The influence of occupational chronic lead exposure on the levels of selected pro-inflammatory cytokines and angiogenic factors

Cited by 23 publications

References 41 publications

Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Effects of Azolla pinnata Ethanolic Extract against Lead-Induced Hepatotoxicity in Rats

Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Effects of Azolla pinnata Ethanolic Extract against Lead-Induced Hepatotoxicity in Rats

Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats

The effect of subacute lead exposure on selected blood inflammatory biomarkers and angiogenetic factors

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