The influence of obesity and obstructive sleep apnea on metabolic hormones

Sánchez‐de‐la‐Torre, Manuel; Mediano, Olga; Barceló, Antònia; Piérola, Javier; Peña, Mónica de la; Esquinas, Cristina; Miro, Angelina; Durán-Cantolla, Joaquín; Agustí, Àlvar; Capote, Francisco; Marı́n, José Marı́a; Montserrat, Josep M.; García‐Río, Francisco; Barbé, Ferrán

doi:10.1007/s11325-011-0552-7

Cited by 62 publications

(67 citation statements)

References 31 publications

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“…A similar result was obtained in a previous study (5), suggesting that apoA1concenteration may not be affected by the excess oxidative stress in sleep apnea. In our study OSA was not associated with alterations in adiponectin and insulin sensitivity, consistent with a recent study showing an association between adiponectin and obesity, but not OSA (35).…”

Section: Discussionsupporting

confidence: 93%

Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea

Yadav

Aghamohammadzadeh

Liu

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionsupporting

confidence: 93%

Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea

Yadav

Aghamohammadzadeh

Liu

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…One of them was randomized clinical trial (RCT) [19], the remaining studies were observational [20][21][22][23][24][25][26][27][28][29]. One study [27] reported results separately for obese group and non-obese group. The information of author, year of publication, nation, sample size, inclusion criteria, mean daily CPAP usage time, therapy duration and study design of each study was presented in Table 1.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis

Chen

Lin

Liu

2016

Chest

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ObjectiveObstructive sleep apnea (OSA) has been suggested to be associated with low levels of adiponectin. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; however, previous studies assessing the effect of CPAP on adiponectin in patients with OSA yielded conflicting results. The present meta-analysis was performed to determine whether CPAP therapy could increase adiponectin levels. MethodsTwo reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before February 2015. Information on characteristics of subjects, study design and pre-and post-CPAP treatment of serum adiponectin was extracted for analysis. Standardized mean difference (SMD) was used to analyze the summary estimates for CPAP therapy. ResultsEleven studies involving 240 patients were included in this meta-analysis, including ten observational studies and one randomized controlled study. The meta-analysis showed that there was no change of adiponectin levels before and after CPAP treatment in OSA patients (SMD = 0.059, 95% confidence interval (CI) = −0.250 to 0.368, z = 0.37, p = 0.710). Subgroup analyses indicated that the results were not affected by age, baseline body mass index, severity of OSA, CPAP therapy duration, sample size and racial differences.

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“…Five articles were excluded from the sample because of following reasons: four papers due to lack of data for the necessary calculation means and SMD [16,[23][24][25], another research because of the inclusion of children [26]. At last, 10 articles, containing 2 clinical randomized controlled studies, which included 289 patients met the inclusion criteria were analyzed in meta-analysis [9][10][11][12][13][14][15][17][18][19]. The principal characteristics of these studies are outlined in Table 1.…”

Section: Results General Characteristics Of Studiesmentioning

confidence: 99%

“…Alternatively, subgroup analysis suggested that possible factors which could influence the results of CPAP therapy were not observed. [11]. As we know, many disorders, such as OSA [4], overweight [5], and insulin resistance [30], were found to be associated with decreased adiponectin levels.…”

Section: Discussionmentioning

confidence: 99%

“…So far, a large majority of studies had evaluated clinical effects of CPAP on serum concentration of adiponectin in OSA patients [11,12]. However, the findings remain equivocal, some studies showed an increase of adiponectin levels were determined in OSA patients after CPAP treatment [11][12][13][14][15], whereas others did not [9,10,[16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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No elevation of serum adiponectin in OSA patients after continuous positive airway pressure treatment: a meta-analysis

et al. 2016

Sleep Biol. Rhythms

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It is reported that the level of serum adiponectin is closely associated with status of obstructive sleep apnea (OSA). However, the effect of continuous positive airway pressure (CPAP) on adiponectin concentration remains controversial. Therefore, the aim of study is to testify the hypothesis that there is a systematic elevation in serum adiponectin with CPAP. We reviewed relevant studies by searching Medline, Pubmed, Embase, and the Cochrane library from 2006 to 2014. Eligible studies which focused on effects of CPAP on adiponectin levels in OSA patients, were identified by two independent reviewers. RevMan and STATA software were utilized for data synthesis and analysis. Association between CPAP and adiponectin was evaluated by polled analysis, and subgroup analysis, basing on detection method, duration of CPAP, sample size, body mass index (BMI), apnea hypopnea index and regional distribution. In total 10 articles were enrolled into the meta-analysis. The results demonstrated that standardised mean difference of the adiponectin levels pre-and post-CPAP therapy was -0.04 (95 % CI -0.21 to 0.12), test for overall effect z = 0.49 (P = 0.62). Subgroup analysis showed that differences in detection method, duration of CPAP, sample size, BMI, OSA severity and regional distribution did not affect the results of polled analysis. The study demonstrated that there was no systematic change in serum adiponectin with CPAP in OSA patients.

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The influence of obesity and obstructive sleep apnea on metabolic hormones

Cited by 62 publications

References 31 publications

Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea

Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea

Effect of Continuous Positive Airway Pressure on Adiponectin in Patients With Obstructive Sleep Apnea: A Meta-analysis

No elevation of serum adiponectin in OSA patients after continuous positive airway pressure treatment: a meta-analysis

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