The Influence of Nutrition on Lung Development before and after Birth

Harding, Richard; Matteo, Robert De

doi:10.1016/b978-0-12-799941-8.00019-5

Cited by 7 publications

(15 citation statements)

References 158 publications

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“…The increase in lactate and the significant depletion of ATP in NCDH sug- Although all nitrofen-treated animals showed an increase in lactate compared to control, further induction of the lactate elevation in nitrofen-CDH was observed in this study. The lactate production in the lung is higher than in other tissues [34]. One potential explanation is that the lung has evolved to utilize aerobic glycolysis to decrease the local oxygen consumption to deliver more oxygen to other tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Even though normal pulmonary development occurs in the uterus in a relatively hypoxic environment, compression in the fetal CDH lungs by the abdominal content could decrease the lung perfusion, causing a drop in the nutrients and oxygen delivery. Previous studies demonstrated that excessive prenatal lung hypoxia has significant and lasting effects on the pulmonary vasculature, structurally and functionally [ 34 , 35 , 36 ]. On the other hand, cells undergo anaerobic metabolism under hypoxia [ 37 ], putting them at risk of energetic failure if unable to produce enough ATP for cellular functions [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

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Lung Metabolomics Profiling of Congenital Diaphragmatic Hernia in Fetal Rats

et al. 2021

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Congenital diaphragmatic hernia (CDH) is characterized by the herniation of abdominal contents into the thoracic cavity during the fetal period. This competition for fetal thoracic space results in lung hypoplasia and vascular maldevelopment that can generate severe pulmonary hypertension (PH). The detailed mechanisms of CDH pathogenesis are yet to be understood. Acknowledgment of the lung metabolism during the in-utero CDH development can help to discern the CDH pathophysiology changes. Timed-pregnant dams received nitrofen or vehicle (olive oil) on E9.5 day of gestation. All fetal lungs exposed to nitrofen or vehicle control were harvested at day E21.5 by C-section and processed for metabolomics analysis using nuclear magnetic resonance (NMR) spectroscopy. The three groups analyzed were nitrofen-CDH (NCDH), nitrofen-control (NC), and vehicle control (VC). A total of 64 metabolites were quantified and subjected to statistical analysis. The multivariate analysis identified forty-four metabolites that were statistically different between the three groups. The highest Variable importance in projection (VIP) score (>2) metabolites were lactate, glutamate, and adenosine 5′-triphosphate (ATP). Fetal CDH lungs have changes related to oxidative stress, nucleotide synthesis, amino acid metabolism, glycerophospholipid metabolism, and glucose metabolism. This work provides new insights into the molecular mechanisms behind the CDH pathophysiology and can explore potential novel treatment targets for CDH patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lung Metabolomics Profiling of Congenital Diaphragmatic Hernia in Fetal Rats

et al. 2021

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“…Selenium acts together with vitamin E to prevent peroxide formation [ 9 ]. In rats selenium deficiency impairs lung development, in particular alveolar septation [ 146 ].…”

Section: Influence Of Micronutrients On Lung Developmentmentioning

confidence: 99%

“…Nutrition has a key role in prenatal lung development, directly affecting mechanisms of lung growth but also influencing developmental programming through epigenetic changes [ 7 , 8 ]. The influence of nutrition on lung growth also continues in post-natal life, especially in early infancy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Nutrition and Lung Growth

Arigliani¹,

Spinelli²,

Liguoro³

et al. 2018

Nutrients

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Experimental evidence from animal models and epidemiology studies has demonstrated that nutrition affects lung development and may have a lifelong impact on respiratory health. Chronic restriction of nutrients and/or oxygen during pregnancy causes structural changes in the airways and parenchyma that may result in abnormal lung function, which is tracked throughout life. Inadequate nutritional management in very premature infants hampers lung growth and may be a contributing factor in the pathogenesis of bronchopulmonary dysplasia. Recent evidence seems to indicate that infant and childhood malnutrition does not determine lung function impairment even in the presence of reduced lung size due to delayed body growth. This review will focus on the effects of malnutrition occurring at critical time periods such as pregnancy, early life, and childhood, on lung growth and long-term lung function.

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“…Algunos nutrientes son determinantes de los cambios epigenéticos que modifican el desarrollo pulmonar [1]. Sin embargo, la influencia sobre el crecimiento pulmonar no acaba en el momento del nacimiento, pues se extiende a la edad posnatal, especialmente en la infancia temprana [2].…”

Section: Nutrición En La Prevención De Las Enfermedades Respiratorias Crónicasunclassified

Aspectos Nutricionales De Las Enfermedades Respiratorias Cronicas De La Infancia

Vildoso¹,

Mario²

2019

Neumol Pediatr

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Las enfermedades respiratorias crónicas comprometen la oxigenación en grado variable y ocasionan problemas en el uso de los nutrientes, la generación de energía y la utilización de ésta por los distintos tejidos y órganos, con potencial daño en la función respiratoria y en los sistemas no respiratorios. La evidencia disponible señala que tanto la energía disponible y algunos micronutrientes, particularmente con actividad antioxidante, durante la gestación, son claves para un adecuado desarrollo pulmonar y por lo tanto una adecuada función pulmonar en prematuros, lactantes y niños mayores, en particular si cursan con displasia broncopulmonar. Sin embargo tanto la desnutrición materna y fetal, como las deficiencias de ciertos nutrientes y la presencia de sobrepeso u obesidad en el niño, influirían en el desarrollo de asma en la infancia. En lo referente a la asistencia nutricional, la corrección del déficit nutricional así como de micronutrientes, es indispensable en el tratamiento de enfermedades como la displasia broncopulmonar, la bronquiolitis obliterante y el asma. Esta revisión pretende establecer cómo la nutrición determina el desarrollo, evolución y pronóstico de estas patologías y la necesidad de considerar la asistencia nutricional en la atención integral de estos pacientes.

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The Influence of Nutrition on Lung Development before and after Birth

Cited by 7 publications

References 158 publications

Lung Metabolomics Profiling of Congenital Diaphragmatic Hernia in Fetal Rats

Lung Metabolomics Profiling of Congenital Diaphragmatic Hernia in Fetal Rats

Nutrition and Lung Growth

Aspectos Nutricionales De Las Enfermedades Respiratorias Cronicas De La Infancia

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