The influence of natural mineral water on the structural and functional changes in the rat kidneys under urolithiasis modelling

Abstract

In the experiment on the white Wistar rats, the authors evaluated kidneys changes in urolithiasis modelling (Kidney stone disease, KSD) and the possibility of correcting these changes by internal use of the mineral water (MW) with high organic matter content. The results of the studies revealed structural pathological changes in the kidneys in the form of changes of the part of glomeruli capillaries and gross changes in the kidneys tubules and interstitial layers. At the same time, the functional kidneys activity is manifested in the form of increased urination and a significant increase in urination. Urine metabolic characteristics are also change. The use of MW leads to an improvement in the capillaries of the renal corpuscles structure and almost complete restoration of the tubules structure. The functional activity of the kidneys and the quality of urine have significantly improving. The authors believe that the organic compounds of MW, which mainly determine its biological activity, contribute to the improvement of the regulation of metabolic processes and, accordingly, have a positive effect on the structural and functional parameters of the kidneys.. Keywords: urolithiasis, structural and functional characteristics of the kidneys, mineral water,

Determining the State of the Structural-Functional Continuum of the Kidney Under the Influence of Natural Mineral Water With Increased Content of Organic Substances

“…This relationship is not evident under physiological loads or, for example, when using natural therapeutic resources (NTR), particularly mineral waters (MW) of different physical and chemical compositions. This is especially true for NTRs with a high content of organic matter (C org ), which tend to affect the body's regulatory mechanisms [15][16][17][18][19][20]. One such factor, which is a priority for Ukraine, is considered to be natural mineral waters (MWs) with a high C org content.…”

“…При фізіологічних навантаженнях, або, наприклад при застосуванні природних лікувальних ресурсів (ПЛР) зокрема мінеральних вод (МВ) різного фізико-хімічного складу, такий зв'язок не наочний. Особливо це актуально для ПЛР з підвищеним вмістом органічних речовин (С орг ), яким властиво впливати на регуляторні механізми організму [15][16][17][18][19][20]. Одним з таких чинників, який є пріоритетом України, вважаються природні мінеральні води (МВ) з підвищеним вмістом С орг .…”