The Influence of Naringin on the Oxidative State of Rats with Streptozotocin- Induced Acute Hyperglycaemia

Mamdouh, Mediana; Monira, A.

doi:10.1515/znc-2004-9-1018

Cited by 56 publications

(6 citation statements)

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“…In rodents, naringin reversed metabolic complications by ameliorating oxidative stress in mice as indicated by improved GPx activity and decreased MDA levels (Adebiyi et al, 2015;Liu et al, 2016). Naringin also had a protective effect in diabetic animals via improving antioxidant enzymes such as SOD, CAT, and GPx in hyperglycemic rats (Ali & El Kader, 2004;Punithavathi et al, 2008). In the current study, dietary naringin improved oxidative stability in pigs via increasing SOD and T-AOC activity in meat, as well as SOD and GPx activities in the liver.…”

Section: Discussionsupporting

confidence: 54%

Naringin supplementation affects performance, carcass traits, meat quality and oxidative stability of finishing pigs

Wang¹,

Wang²,

Qi³

et al. 2020

SA J. An. Sci.

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Naringin is a major flavanone derivate that has many important biological functions in animals. However, its effect on pigs is unknown. The aim of this study was to investigate the effect of naringin supplementation on performance, carcass traits, meat quality and oxidative stability in finishing pigs. Ninety-six pigs, with an average initial body weight of 66.2 ± 0.63 kg, were randomly divided into four groups. One group was fed a basal diet without supplementation (control), and the three others were fed diets supplemented with 0.5, 1.0 or 1.5 g naringin /kg DM of feed for 50 days. Each treatment was replicated six times with four pigs per replicate. Feed and water were available ad libitum. The 0.5 g/kg naringin treatment group had an improved loin eye muscle area, reduced serum triglycerides and were leaner compared with the other groups. Pigs in the 1.5 g/kg naringin treatment had higher pH45min values and inosine monophosphate concentrations, and lower MyHC IIb mRNA expression in muscle than the other groups. MyHC IIa mRNA expression was significantly up-regulated in all naringin-supplemented diet groups. Naringin significantly increased superoxide dismutase (SOD) activity and total anti-oxidative capacity in meat, as well as SOD and glutathione peroxidase activity in the liver. These results indicate that the dietary addition of naringin at 0.5 g/kg improved carcass characteristics, while 1.5 g/kg improved the oxidative stability and pork quality in finishing pigs. Keywords: antioxidant capacity; carcass characteristics; naringin-supplemented diets; pork quality

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Section: Discussionsupporting

confidence: 54%

Naringin supplementation affects performance, carcass traits, meat quality and oxidative stability of finishing pigs

Wang¹,

Wang²,

Qi³

et al. 2020

SA J. An. Sci.

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show abstract

“…Furthermore, IL-6 and TNF-a concentrations were found to be higher in people with insulin resistance and type 2 diabetes in various investigations (Kado et al, 1999;Pickup et al, 2000). Naringin's hypoglycemic effect has been thoroughly documented (Jung et al, 2004;Ali and Kader, 2004). Cotreatment of streptozotocininduced diabetes in rats with naringin (30 mg/kg) and vitamin C (50 mg/kg) improved insulin concentration and reduced oxidative stress (Punithavathi, 2008).…”

Section: Antidiabetic Properties Of Naringinmentioning

confidence: 99%

Antidiabetic and Antihypertensive Properties of Naringin: A Review

Ghosh¹,

Sarkar²,

Mistry³

et al. 2023

Intern. J. Zool. Invest.

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Despite the availability of various medications that successfully lower blood glucose levels and blood pressure, diabetes mellitus (DM) and hypertension (HTN) continue to place a tremendous strain on global medical resources. The prevention of numerous complications, which remain the leading cause of mortality due to these diseases, is a key challenge in the management of these two disorders. Phytochemicals are a rich source of plantderived molecules that are critical for the discovery of substances with medicinal potential. Flavonoids have a history of being important natural components with a variety of biological functions. Naringin, a flavanone glycoside found mostly in grapefruit and citrus fruits, is a natural flavanone glycoside. Obesity, diabetes, high blood pressure, and metabolic syndrome can all be treated with naringin. A few molecular pathways underpinning its beneficial properties have been discovered. Naringin has a wide spectrum of pharmacological properties, including antiinflammatory and cancer-fighting properties.

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“…Naringin significantly improvesthe hypoglycemic and antioxidative activity in STZ induced diabetic rats. There was a depletion in glucose level and TBARS level and an increment in serum insulin concentration and antioxidative enzyme activities in diabetic rats treated with naringin (CAT, SOD, GPx, PON) (Mamdouh and Abd, 2004). Naringin protects pancreatic β-cells against oxidative stressinduced apoptosis by limiting both intrinsic (mitochondria-mediated) and extrinsic (death receptormediated) pathways (Lim et al, 2018).…”

Section: Naringinmentioning

confidence: 99%

Antidiabetic potential of natural phytochemical antioxidants

FAHIM¹,

RAHMAN²,

NASEEM³

et al. 2022

JCNB

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Diabetes mellitus is a chronic metabolic ailment caused due to complex interactions of genetic and environmental factors (dietary and lifestyle). It causes remarkable morbidity and mortality due to microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (heart attack, peripheral vascular disease, and stroke) complications. Treatment of microvascular complications focuses on blood sugar control. Although preventing macrovascular complications requires correcting classical cardiovascular risk factors that involve insulin resistance (metabolic) syndrome. The use of traditional drugs adopts several antidiabetic remedies. These drugs are effectivebecause most of these drugs are taken by patients for their entire life and causeseveral adverse effects like diarrhoea, abdominal distention, and flatulence emanate by intaking these drugs. Due to these restrictions,there is a need to explore management strategies in medicinal plants with cost-effective antidiabetic potentials and fewer or negligible side effects. Applying traditional medicine for diabetes and its associated complications has received increasing attention. This review explores the antidiabetic potential of some commonly and extensively used phytochemicals obtained from traditional medicinal plants.

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The Influence of Naringin on the Oxidative State of Rats with Streptozotocin- Induced Acute Hyperglycaemia

Cited by 56 publications

References 0 publications

Naringin supplementation affects performance, carcass traits, meat quality and oxidative stability of finishing pigs

Naringin supplementation affects performance, carcass traits, meat quality and oxidative stability of finishing pigs

Antidiabetic and Antihypertensive Properties of Naringin: A Review

Antidiabetic potential of natural phytochemical antioxidants

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