The Influence of NaCl Supplementation on the Postnatal Development of Urinary Excretion of Noradrenaline, Dopamine, and Serotonin in Premature Infants

Sulyok, E.; Gyódi, G; Erti, Tibor; Bódis, József; Hartmann, G

doi:10.1203/00006450-198501000-00002

Cited by 15 publications

(5 citation statements)

References 18 publications

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“…The results of this study show that motor and neuropsychological development of a group of premature infants, studied at 10-13 years of age, was greatly influenced by whether or not they had received sodium supplementation of their feeds during the neonatal period (postnatal days [4][5][6][7][8][9][10][11][12][13][14]. The 16 children in the supplemented group had significantly better developed motor skills (table 3) and perceptual organisation skills and superior IQs (table 4) than the 21 in the unsupplemented control group.…”

Section: Discussionmentioning

confidence: 77%

Effect of salt supplementation of newborn premature infants on neurodevelopmental outcome at 10-13 years of age

Al-Dahhan

Jannoun²,

Haycock

2002

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Background: The nutritional requirements of prematurely born infants are different from those of babies born at term. Inadequate or inappropriate dietary intake in the neonatal period may have long term adverse consequences on neurodevelopmental function. The late effect of neonatal sodium deficiency or repletion in the premature human infant on neurological development and function has not been examined, despite evidence in animals of a serious adverse effect of salt deprivation on growth of the central nervous system. Methods: Thirty seven of 46 children who had been born prematurely (gestational age of 33 weeks or less) and allocated to diets containing 1-1.5 mmol sodium/day (unsupplemented) or 4-5 mmol sodium/day (supplemented) from the 4th to the 14th postnatal day were recalled at the age of 10-13 years. Detailed studies of neurodevelopmental performance were made, including motor function and assessment of intelligence (IQ), memory and learning, language and executive skills, and behaviour. Sixteen of the children were found to have been in the supplemented group and 21 in the unsupplemented group. Results: Children who had been in the supplemented group performed better in all modalities tested than those from the unsupplemented group. The differences were statistically significant (analysis of variance) for motor function, performance IQ, the general memory index, and behaviour as assessed by the children's parents. The supplemented children outperformed the unsupplemented controls by 10% in all three components of the memory and learning tests (difference not significant but p < 0.1 for each) and in language function (p < 0.05 for object naming) and educational attainment (p < 0.05 for arithmetic age). Conclusions: Infants born at or before 33 weeks gestation require a higher sodium intake in the first two weeks of postnatal life than those born at or near term, and failure to provide such an intake (4-5 mmol/day) may predispose to poor neurodevelopmental outcome in the second decade of life.

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Section: Discussionmentioning

confidence: 77%

Effect of salt supplementation of newborn premature infants on neurodevelopmental outcome at 10-13 years of age

Al-Dahhan

Jannoun²,

Haycock

2002

Archives of Disease in Childhood - Fetal and Neonatal Edition

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“…The excretion of dopamine is higher in the pediatric population than in elderly subjects [190]. However, urinary dopamine increases postnatally in very low birth weight infants [191, 192]. In rats, intrarenal levels of dopamine have a tendency to increase between 3 and 20 days after birth, but significantly decrease between 20 to 80 days after birth [193].…”

Section: Development Of Renal Dopaminementioning

confidence: 99%

Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice

et al. 2008

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Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D1-like (D1, D5) and D2-like (D2, D3, D4) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.

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“…Urinary DA excretion, however, increased with increasing postnatal age. Sulyok et al [12] found that in sodium-supplemented preterm infants urinary NE and DA excretion did not increase with increasing postnatal age unlike in non-supplemented infants, suggesting that hyponatremia could be indirectly stimulating the sympathoadrenal activity in non-supplemented infants. We conclude that the NE excretion, which reflects plasma NE concentrations, reflects the general sympathoadrenal activity in the newborn infant, whereas DA excretion is primarily of renal origin.…”

Section: Discussionmentioning

confidence: 94%

Effect of extreme prematurity on renal dopamine and norepinephrine excretion during the neonatal period

Vanpée

Herin

Lagercrantz

et al. 1997

Pediatric Nephrology

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Dopamine (DA), produced in proximal tubular cells, is believed to be an important intrarenal natriuretic hormone. Experimental studies have shown that the natriuretic effect of DA is less pronounced in the fetal kidney. We have evaluated renal DA and norepinephrine (NE) in the neonatal period, using urinary excretion as an indicator of renally produced/released-catecholamines. In very low-birth-weight infants (25-30 weeks gestational age) there was an increase in urinary DA (pmol/mumol urinary creatine) and NE (pmol/mumol urinary creatinine) from 1 to 13 days postnatal age, despite a decrease in sodium excretion. Urinary NE correlated with plasma NE, whereas plasma DA was undetectable. In summary, NE excretion parallels plasma levels and could reflect the general sympathoadrenal activity, whereas DA is primarily of renal origin. Renal DA and NE increase in the first 2 weeks of life in immature infants. We conclude that the catecholamine system of the human kidney undergoes maturational changes postnatally.

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The Influence of NaCl Supplementation on the Postnatal Development of Urinary Excretion of Noradrenaline, Dopamine, and Serotonin in Premature Infants

Cited by 15 publications

References 18 publications

Effect of salt supplementation of newborn premature infants on neurodevelopmental outcome at 10-13 years of age

Effect of salt supplementation of newborn premature infants on neurodevelopmental outcome at 10-13 years of age

Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice

Effect of extreme prematurity on renal dopamine and norepinephrine excretion during the neonatal period

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