The influence of mouse strain and housing on the immune response

Rabin, Bruce S.; Lyte, Mark; Hamill, Ellen C.

doi:10.1016/0165-5728(87)90027-0

Cited by 36 publications

(10 citation statements)

References 9 publications

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“…However, sex differences in corticosterone concentrations were unaffected by the social environment. This observation is consistent with previous work in mice, which demonstrated that differences in antibody production between isolated and group-housed animals were not explained by serum corticosterone concentrations (Rabin et al, 1987b). …”

Section: Discussionsupporting

confidence: 93%

“…The stable presence or absence of familiar conspecifics has long been known to alter immune responsiveness in rodent models, with social isolation in particular generally associated with impaired measures of immune function (Edwards et al, 1980; Plaut et al, 1969; Rabin et al, 1987a; Vessey, 1964). Social isolation impacts diverse aspects of the immune system: individual- relative to group-housing results in decreased mitogen-stimulated lymphocyte proliferation (Bartolomucci et al, 2003; Jessop et al, 1988), decreased antigen-specific IgG production (Demas et al, 2004; Klein et al, 1997; Shanks et al, 1994), delayed wound healing (Detillion et al, 2004), increased parasitic load (Schuster & Schaub, 2001), and increased tumor growth following tumor cell transplantation (Kerr et al, 1997; Kerr et al, 2001; Strange et al, 2000) across different animal models.…”

Section: Introductionmentioning

confidence: 99%

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Sex-specific social regulation of inflammatory responses and sickness behaviors

Yee¹,

Prendergast²

2010

Brain, Behavior, and Immunity

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In many mammals, the availability of familiar conspecifics in the home environment can affect immune function and morbidity. Numerous sex differences exist in immune responses, but whether the social environment impacts the immune system differently in males and females is not fully understood. This study examined behavioral and physiological responses to simulated bacterial infection in adult male and female Wistar rats housed either with 3 same-sex non-siblings (Group) or alone (Isolate). Rats were injected with bacterial lipopolysaccharide (E. coli LPS; 150 µg/kg, i.p.), and behavioral (orectic, locomotor, and social) and physiological (thermoregulatory, cytokine, and corticosterone) inflammatory responses were measured. Among males, LPS-induced fever, suppressed locomotor activity, and inhibited feeding behavior and the magnitude of these responses were greater in Isolate relative to Group housed individuals. In contrast, among females group housing exacerbated behavioral and physiological symptoms of simulated infection. LPS treatments elicited IL-1β production in all groups, but plasma IL-1β concentrations were higher and peaked earlier in Isolate relative to Group males, and in Group relative to Isolate females. Furthermore, plasma concentrations of TNFα and IL-2 were higher in Group relative to Isolate males. Plasma corticosterone concentrations did not vary as a function of social housing conditions. Together, the data indicate that the social environment markedly influences innate immune responses. Group housing exacerbates inflammatory responses and sickness behaviors in females, but attenuates these responses in males. These sex differences are mediated in part by differential effects of the social environment on pro-and anti-inflammatory cytokine production.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Sex-specific social regulation of inflammatory responses and sickness behaviors

Yee¹,

Prendergast²

2010

Brain, Behavior, and Immunity

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“…However, the intraspecific aggression expressed by males of this strain made them difficult to house in groups, and thus the older individuals were housed individually. In previous studies, housing mice singly has been demonstrated to increase immune responses [26], [27], [28], and would theoretically increase their resistance to infection.…”

Section: Discussionmentioning

confidence: 99%

Inactivation of the CovR/S Virulence Regulator Impairs Infection in an Improved Murine Model of Streptococcus pyogenes Naso-Pharyngeal Infection

et al. 2013

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Streptococcus pyogenes is a leading cause of pharyngeal infection, with an estimated 616 million cases per year. The human nasopharynx represents the major reservoir for all S. pyogenes infection, including severe invasive disease. To investigate bacterial and host factors that influence S. pyogenes infection, we have devised an improved murine model of nasopharyngeal colonization, with an optimized dosing volume to avoid fulminant infections and a sensitive host strain. In addition we have utilized a refined technique for longitudinal monitoring of bacterial burden that is non-invasive thereby reducing the numbers of animals required. The model was used to demonstrate that the two component regulatory system, CovR/S, is required for optimum infection and transmission from the nasopharynx. There is a fitness cost conferred by covR/S mutation that is specific to the nasopharynx. This may explain why S. pyogenes with altered covR/S have not become prevalent in community infections despite possessing a selective advantage in invasive infection.

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“…Assumptions underlying the isolation stress model in mice and rats have been reviewed by Brain (27) and Brain and Benton (28). Recent reports also suggest that differential housing in rodents influences various components of the immune system (6,20,29) and experimental tumor growth (17, …”

Section: Discussionmentioning

confidence: 99%

“…Housing condition is also known to affect immune function. Individually housed mice had higher specific immune responses (6) and higher macrophage activity (20) than did group-housed mice. Mouse natural killer cell activity was reported to be unaffected by long-term differential housing of the animals, although an acute change in housing modulated the response (21).…”

mentioning

confidence: 99%

Effect of Differential Housing in Mice on Natural Killer Cell Activity, Tumor Growth, and Plasma Corticosterone

Hoffman‐Goetz

MacNeil

Arumugam

1992

Experimental Biology and Medicine

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Various forms of stress have been shown to alter natural killer (NK) cell activity and tumorigenesis; however, few studies have measured these two variables simultaneously. Isolation of mice was utilized as a model of stress by which to study NK cell activity and pulmonary metastatic response following a tumor challenge. Male C3H mice were group or individually housed for 3 weeks, after which CIRAS 3 fibrosarcoma tumor cells or the tumor vehicle was injected intravenously (tail vein), NK cell activity, pulmonary metastasis, and plasma corticosterone were measured 1, 7, and 21 days following tumor cell inoculation. Individually housed mice, irrespective of tumor or vehicle condition, had a higher NK response on Day 1 relative to group-housed animals (P less than 0.001). By Day 21, tumor condition, rather than housing, was the major significant factor affecting NK activity (P less than 0.001). Nevertheless, individually housed, tumor-injected mice still had higher NK activity compared with the other treatment groups on Day 21. No effect of housing condition was present for the incidence of pulmonary metastases or frequency of metastases in affected animals. Plasma corticosterone levels generally increased over the study period, with no housing or injection effects at Days 1 and 7. Individually housed, vehicle-injected mice had higher corticosterone levels at Day 21 (P less than 0.01). These data suggest that in response to housing condition, NK cell activity differs in tumor-bearing mice and vehicle controls. Furthermore, CIRAS 3 pulmonary tumor formation is not affected by differences in NK activity consequent to housing condition. Plasma corticosterone does not appear to be a major in vivo regulator of NK activity in this experimental tumor system. Finally, the interpretation of housing effects on NK activity and plasma corticosterone levels depends on the temporal window in which sampling occurs.

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The influence of mouse strain and housing on the immune response

Cited by 36 publications

References 9 publications

Sex-specific social regulation of inflammatory responses and sickness behaviors

Sex-specific social regulation of inflammatory responses and sickness behaviors

Inactivation of the CovR/S Virulence Regulator Impairs Infection in an Improved Murine Model of Streptococcus pyogenes Naso-Pharyngeal Infection

Effect of Differential Housing in Mice on Natural Killer Cell Activity, Tumor Growth, and Plasma Corticosterone

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