The influence of morphology on the (hydrolytic degradation of as-polymerized and hot-drawn poly(L-lactide))

Joziasse, Cornelis A.P.; Grijpma, Dirk W.; Bergsma, J. E.; Cordewener, F. W.; Bos, R. R. M.; Pennings, A. J.

doi:10.1007/s003960050335

Cited by 44 publications

(30 citation statements)

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“…Estimates based on in vitro and in vivo degradation studies indicate that highly crystalline PAE degradation debris may even take much longer than that to fully degrade. 25,36,43 From that perspective, the term complete degradation should be used very cautiously. At present, it seems prudent to assume that crystalline debris from PAE implants will remain present in the recipient indefinitely with the potential for the development of unforeseen complications.…”

Section: Discussionmentioning

confidence: 99%

Particulate retrieval of hydrolytically degraded poly(lactide-co-glycolide) polymers

Cordewener

Dijkgraaf

Ong

et al. 2000

J. Biomed. Mater. Res.

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This article describes a technique for the retrieval of polymeric particulate debris following advanced hydrolytic in vitro degradation of a biodegradable polymer and presents the results of the subsequent particle analysis. Granular 80/20 poly(L-lactide-co-glycolide) (PLG) was degraded in distilled, deionized water in Pyrextrade mark test tubes at 80 degrees C for 6 weeks. Subsequently, a density gradient was created by layering isopropanol over the water, followed by a 48-h incubation. Two opaque layers formed in the PLG tubes, which were removed and filtered through 0.2-micrometer polycarbonate membrane filters. In addition, Fourier transform IR spectroscopy (FTIR) was performed to confirm the presence of polymer in the removed layers. The filters were gold sputter coated, and scanning electron microscopy (SEM) images were made. FTIR analysis confirmed that the removed material was PLG. SEM images of the extracts from the upper (lowest density) opaque layer showed a fine, powderlike substance and globular structures of 500-750 nm. The SEM images of the lower (highest density) opaque layer showed particles with a crystalline-like morphology ranging in size from 4 to 30 micrometer. Particulate PLG debris generated with the described technique can be useful for further studies of its biological role in complications associated with poly(alpha-hydroxy)ester implants. This study shows the presence of very persistent nano- and microparticles in the degradation pathway of PLG.

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Section: Discussionmentioning

confidence: 99%

Particulate retrieval of hydrolytically degraded poly(lactide-co-glycolide) polymers

Cordewener

Dijkgraaf

Ong

et al. 2000

J. Biomed. Mater. Res.

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“…18 The in vitro degradation of PLLA fibers in phosphate buffered saline (PBS, pH 7.4) was investigated previously. 19,20 Hyon et al reported that the PLLA fibers produced by melt spinning underwent almost no degradation in PBS at 37°C over 6 months, but these fibers degraded very fast at 100°C and lost their mechanical strength completely after 20 h. 19 Joziasse et al reported that the PLLA fibers prepared by solution spinning exhibited very stable mechanical properties under a static load at room temperature in PBS; these fibers were noted to retain 75% of their initial strength after 5.3 years. 20 The degradation of PLLA fibers in Ringer's lactate solution at 37°C was studied by Pegoretti et al 21 The results showed that the thinner the PLLA fibers, the faster was their degradation.…”

Section: Introductionmentioning

confidence: 95%

In vitro degradation of poly(L‐ lactic acid) fibers in phosphate buffered saline

Yuan

Mak

Yao

2002

J of Applied Polymer Sci

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ABSTRACT:In vitro degradation of poly(L-lactic acid) (PLLA) fibers was studied by incubating the fibers in phosphate buffered saline (pH 7.4) at 37°C for 35-45 weeks. Three kinds of PLLA fibers with different diameters and different initial viscosityaverage molecular weights were tested. The viscosity-average molecular weight, crystallinity, morphology, and tensile properties of the PLLA fibers were monitored along the degradation period. The results showed that the viscosity-average molecular weight of the PLLA fibers dropped gradually during the in vitro degradation period, and it decreased by 40 -60% at the end of the experimental period. The crystallinity of the PLLA fibers measured by differential scanning calorimetry was noted to increase slightly. The tensile moduli, ultimate strengths, and elongations of the fibers did not exhibit significant changes in 35 weeks of degradation but PLLA fibers with a smaller diameter of 113 m showed significant decreases in their ultimate strengths with respect to the initial value after 35-45 weeks of degradation. Microcracks appeared on part of the fiber surfaces, which might ultimately lead to the decrease of the mechanical strength of the PLLA fibers. The spotty defects reported in this study apparently did not affect the mechanical properties of the fibers. The results suggested that the tensile properties of the PLLA fibers were mechanically stable in 35 weeks of in vitro degradation, although their molecular weights decreased remarkably and obvious spotty defects appeared on their surfaces.

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“…After 15 months of incubation, these parameters are up to 60 % higher than at the beginning of the degradation process (σ , E, ε: p < 0.05). This change is associated with faster degradation of the amorphous regions of the polymer [23,24]. Moreover, degradation can be accompanied by the phenomenon of crystallization, i.e.…”

Section: Tests Of Static Propertiesmentioning

confidence: 99%

Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants

et al. 2012

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The biggest challenge in the treatment of arterial stenosis remains the issue of optimization of stent design. Despite continuous improvement in surgical techniques and use of intensive pharmacotherapy, the results of stent coronary interventions may be unsatisfactory, and long-term interaction of a metal implant with a blood vessel results in complications such as recurrent stenosis and thrombosis. Therefore, it is necessary to search for new materials and stent designs to obtain a stent capable of restoring flow in the vessel and disappearing after fulfilling its function. Such stent must also be compatible with the vessel wall to enable regeneration of new structure of endothelium and deeper artery layers damaged during implantation. Consequently, there is ongoing search for functional solutions with minimum effects of long-term implant-tissue interaction. In light of the above, the team investigated the possibility of using biodegradable polymers already mentioned in the literature as a construction material for vascular stent. The study used three polyhydroxyacids based on lactic acid and glycolic acid: poly(l-lactide), poly(lactideco-glycolide) and poly(d,l-lactide-co-glycolide). The research focused on assessing changes in mechanical, thermomechanical, rheological, and fatigue properties during the process of hydrolytic degradation. The analysis also covered the rate of release of degradation products. The results of the conducted tests indicate the possibility of developing a vascular stent with biodegradable polymers.

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The influence of morphology on the (hydrolytic degradation of as-polymerized and hot-drawn poly(L-lactide))

Cited by 44 publications

References 0 publications

Particulate retrieval of hydrolytically degraded poly(lactide-co-glycolide) polymers

Particulate retrieval of hydrolytically degraded poly(lactide-co-glycolide) polymers

In vitro degradation of poly(L‐ lactic acid) fibers in phosphate buffered saline

Mechanical, rheological, fatigue, and degradation behavior of PLLA, PGLA and PDGLA as materials for vascular implants

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