The influence of midazolam on active avoidance retrieval and acquisition rate in rats

Obradović, Dragana; Savić, Miroslav M.; Andjelkovic, Darinka; Ugresic, N.; Bokonjić, Dubravko

doi:10.1016/j.pbb.2003.09.018

Cited by 17 publications

(6 citation statements)

References 54 publications

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“…A similar promnesic action [72,75] has been observed after acute administration affecting imprinting in chicks, a phenomenon first described by Konrad Lorenz. Along the same line, "paradoxical" memory-enhancing effects of benzodiazepines have also been reported in some cases [74]. Mayo et al [11] pursued an hypothesis first made by Sarter et al [76] and found that direct intracerebral administration of beta-CCM (at extremely low doses: 3 µg/0.5 µl) injected into the nucleus basalis magnocellularis of the rat enhanced recognition in a two-trial recognition task.…”

Section: Effects On Memorymentioning

confidence: 87%

From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory

Venault

Chapouthier

2007

The Scientific World JOURNAL

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A number of beta-carbolines are inverse agonists of the GABA-A receptor complex, acting on the benzodiazepine site. They show convulsive properties when administered at high doses, anxiogenic properties at moderate doses, and learning-enhancing effects at low doses. These data suggest a possible physiological relationship, through the GABA-A receptor channel, between memory processes, anxiety, and ultimately, in pathological states, epileptic seizures. This relationship seems to be confirmed partially by experiments on mouse strains selected for their resistance (BR) and sensitivity (BS) to a single convulsive dose of a beta-carboline. These two strains also show differences in anxiety and learning abilities. However, some opposite results found while observing the behavior of the two strains suggest that in addition to pharmacologically induced anxiety, there is spontaneous anxiety, no doubt involving other brain mechanisms.

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Section: Effects On Memorymentioning

confidence: 87%

From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory

Venault

Chapouthier

2007

The Scientific World JOURNAL

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“…On the other hand, ω-3 supplementation may have prevented these morphologic alterations and produced anxiolitic effects in stressed rats. This, in turn could have improved learning, as has been seen with anxiolitic drugs such as midazolam, which facilitates avoidance retrieval in rats [69]. …”

Section: Discussionmentioning

confidence: 99%

Long-term ω-3 fatty acid supplementation induces anti-stress effects and improves learning in rats

2013

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Chronic stress leads to secretion of the adrenal steroid hormone corticosterone, inducing hippocampal atrophy and dendritic hypertrophy in the rat amygdala. Both alterations have been correlated with memory impairment and increased anxiety. Supplementation with ω-3 fatty acids improves memory and learning in rats. The aim of this study was to evaluate the effects of ω-3 supplementation on learning and major biological and behavioral stress markers. Male Sprague–Dawley rats were randomly assigned to three experimental groups: 1) Control, 2) Vehicle, animals supplemented with water, and 3) ω-3, rats supplemented with ω-3 (100 mg of DHA+25 mg of EPA). Each experimental group was divided into two subgroups: one of which was not subjected to stress while the other was subjected to a restraint stress paradigm. Afterwards, learning was analyzed by avoidance conditioning. As well, plasma corticosterone levels and anxiety were evaluated as stress markers, respectively by ELISA and the plus-maze test. Restraint stress impaired learning and increased both corticosterone levels and the number of entries into the open-arm (elevated plus-maze). These alterations were prevented by ω-3 supplementation. Thus, our results demonstrate that ω-3 supplementation had two beneficial effects on the stressed rats, a strong anti-stress effect and improved learning.

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“…Regarding the retrieval process, some experiments carried out in rats showed an enhancement effect from benzodiazepines in this phase in a fear-conditioning paradigm (Harris and Westbrook, 1998) and in an active avoidance task (Obradovic et al, 2004). However, pure retrieval deficits have also been observed in both humans and animals (Lombardi et al, 1997;Pompeia et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation

et al. 2013

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The influence of midazolam on active avoidance retrieval and acquisition rate in rats

Cited by 17 publications

References 54 publications

From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory

From the Behavioral Pharmacology of Beta-Carbolines to Seizures, Anxiety, and Memory

Long-term ω-3 fatty acid supplementation induces anti-stress effects and improves learning in rats

Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation

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