A B S T R A C TFor both ethical and practical reasons accurate tissue simulant materials are essential for ballistic testing applications. A wide variety of different materials have been previously adopted for such roles, ranging from gelatin to ballistics soap. However, while often well characterised quasi-statically, there is typically a paucity of information on the high strain-rate response of such materials in the literature. Here, building on previous studies by the authors on other tissue analogues, equation-of-state data for the elastomeric epithelial/muscular simulant material Perma-Gel ® is presented, along with results from a series of ballistic tests designed to illustrate its impact-related behaviour. Comparison of both hydrodynamic and ballistic behaviour to that of comparable epithelial tissues/analogues (Sylgard ® and porcine muscle tissue) has provided an insight into the applicability of both Perma-Gel ® and, more generally, monolithic simulants for ballistic testing purposes. Of particular note was an apparent link between the high strain-rate compressibility (evidenced in the Hugoniot relationship in the Us-up plane) and subsequent ballistic response of these materials. Overall, work conducted in this study highlighted the importance of fully characterising tissue analogues -with particular emphasis on the requirement to understand the behaviour of such analogues under impact as part of a system as well as individually.