The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials

Zhang, Juyi; Wang, Yubin; Xu, Hao; Yang, Juan

doi:10.1097/sle.0000000000000601

Cited by 9 publications

(15 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to a recent meta-analysis in cholecystectomy, melatonin interventions showed no substantial impact on sleep quality and pain score after 1 and 3 hours. 31 However, Kirksey A. et al concluded melatonin did not have effect on subjective sleep assessment but improved sleep efficiency and sleep time by actigraphy wrist bracelet measurement. 32 Acute postoperative pain after hysterectomy may be complicated by anxiety state and psychological factors.…”

Section: Discussionmentioning

confidence: 97%

Efficacy of Melatonin on Postoperative Outcomes after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial

Laosuwan,

Dechaworawut,

Rodanant

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Melatonin became a part of multimodal analgesia in several recent studies because of its analgesic, anxiolytic and anti-inflammatory properties. Incidence of anxiety and pain in patients who underwent hysterectomy are not low. Moreover, preoperative anxiety was related to postoperative pain. The hypothesis of this study was whether melatonin could improve pain and other postoperative conditions after hysterectomy.Methods: A randomized, double-blinded, placebo-controlled trial recruitment of 54 patients, aged between 18 and 65 years old, planned to undergo hysterectomy, with or without oophorectomy under spinal anesthesia. The patients were allocated to receive 4 mg prolonged-release melatonin at night before surgery and in the morning before surgery or 2 doses of placebo at the same time point. Morphine consumption within 24 hours with patient-controlled analgesia machine and visual analog scale (VAS) pain score were recorded. In addition, quality of sleep, Thai standard anxiety level score, fatigue, general well-being and satisfaction score were measured by a blinded assessor and analyzed.Results: Mean of cumulative dose of morphine consumption in melatonin and placebo group were 33.04 ±10.42 and 42.63 ±8.21 mg, respectively. (p < 0.001) Mean of postoperative VAS pain scale was lower in the melatonin group at recovery room arrival (T0) (23.41 vs 8.07, p = 0.01). However, there was not a significant difference between postoperative groups at 1(T1), 6 (T6) and 24 h (T24). Fatigue and general well-being score in the melatonin group were better than the placebo group.Conclusion: Prolonged-release formulation of melatonin decreased pain intensity in post anesthetic care room and lowered doses of postoperative morphine within 24 hours after surgery. Postoperative fatigue, general well-being and satisfaction scores were better in the treatment group. However, there was no anxiety and sleep quality improvement. Melatonin may be an additional choice of multimodal analgesia for hysterectomy. Clinical trial registration: TCTR20140516001, Registered 16 May, 2014, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=1076, Efficacy of melatonin on postoperative outcomes after hysterectomy: a randomised, doubl-blinded, placebo-controlled trial

show abstract

Section: Discussionmentioning

confidence: 97%

Efficacy of Melatonin on Postoperative Outcomes after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial

Laosuwan,

Dechaworawut,

Rodanant

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Similar to a recent meta-analysis in cholecystectomy, melatonin interventions showed no substantial impact on sleep quality and pain score after 1 and 3 hours. [33] However, Kirksey A. et al concluded melatonin did not have effect on subjective sleep assessment but improved sleep e ciency and sleep time by actigraphy wrist bracelet measurement. [34] Acute postoperative pain after hysterectomy may be complicated by anxiety state and psychological factors.…”

Section: Discussionmentioning

confidence: 97%

Efficacy of Melatonin on Postoperative Outcomes After Hysterectomy: A Randomized, Double-Blind, Placebo-Controlled Trial

Laosuwan

Dechaworawut

Rodanant

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Melatonin became a part of multimodal analgesia in several recent studies because of its analgesic, anxiolytic and anti-inflammatory properties. Incidence of anxiety and pain in patients undergoing hysterectomy is not low. Moreover, preoperative anxiety is related to postoperative pain. The hypothesis of this study was whether melatonin could improve pain and other postoperative conditions after hysterectomy.Methods: A randomized, double-blinded, placebo-controlled trial involved recruitment of 54 patients, aged between 18 and 65 years old, planned to undergo hysterectomy, with or without oophorectomy under spinal anesthesia. The patients were allocated to receive 4 mg prolonged-release melatonin at night before surgery and in the morning before surgery or 2 doses of placebo at the same time point. Morphine consumption within 24 hours with patient-controlled analgesia machine and visual analog scale (VAS) pain score were recorded. In addition, quality of sleep, Thai standard anxiety level score, fatigue, general well-being and satisfaction score were measured by a blinded assessor and analyzed.Results: Mean of cumulative dose of morphine consumption in melatonin and placebo group were 33.04 ±10.42 and 42.63 ±8.21 mg, respectively. (p < 0.001) Mean of postoperative VAS pain scale was lower in the melatonin group at recovery room arrival (T0) (23.41 vs 8.07, p = 0.01). However, there was not a significant difference between postoperative groups at 1(T1), 6 (T6) and 24 h (T24). Fatigue and general well-being score in the melatonin group were better than the placebo group.Conclusion: Prolonged-release formulation of melatonin decreased pain intensity in post anesthetic care room and lowered doses of postoperative morphine within 24 hours after surgery. Postoperative fatigue, general well-being and satisfaction scores were better in the treatment group. However, there was no anxiety and sleep quality improvement. Melatonin may be an additional choice of multimodal analgesia for hysterectomy. Clinical trial registration: TCTR20140516001, Registered 16 May, 2014, http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=1076, Efficacy of melatonin on postoperative outcomes after hysterectomy: a randomised, doubl-blinded, placebo-controlled trial

show abstract

“…Overall, the duration of melatonin administration ranged from 3 to 3.5 years, or preoperative temporarily. [24,25,29] Diagnostic criteria for reported mental illness also varied, using NINCDS-ADRDA, ICD-10, or DSM-IV. [20,[30][31][32] The most frequently performed subgroup analysis was high versus low dose of melatonin.…”

Section: Study Characteristicsmentioning

confidence: 99%

Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials

Lim

Park

Koyanagi

et al. 2022

Pharmacological Research

View full text Add to dashboard Cite

The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials

Cited by 9 publications

References 37 publications

Efficacy of Melatonin on Postoperative Outcomes after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial

Efficacy of Melatonin on Postoperative Outcomes after Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial

Efficacy of Melatonin on Postoperative Outcomes After Hysterectomy: A Randomized, Double-Blind, Placebo-Controlled Trial

Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials

Contact Info

Product

Resources

About