The Influence of Maternal Iron-deficiency Anaemia on the Haemoglobin of the Infant

Lanzkowsky, Philip

doi:10.1136/adc.36.186.205

Cited by 36 publications

(13 citation statements)

References 23 publications

(28 reference statements)

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“…There was no equivalent difference in cord ferritin concentrations. There are conflicting reports on the influence of maternal iron stores on fetal stores (Sturgeon, 1959;Lanzkowsky, 1961;Rios et al, 1975). We have shown in a previous publication that despite prophylactic iron therapy the maternal ferritin falls with increasing gestation and that 30 per cent of normal patients had low ferritin levels at term although only 6 per cent had low haemoglobin levels (Kelly et al, 1977).…”

Section: Resultsmentioning

confidence: 99%

Observations on Maternal and Fetal Ferritin Concentrations at Term

Kelly

MacDonald

McDougall

1978

BJOG

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Section: Resultsmentioning

confidence: 99%

Observations on Maternal and Fetal Ferritin Concentrations at Term

Kelly

MacDonald

McDougall

1978

BJOG

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“…Earlier studies on iron status during pregnancy suggested that children born to severely iron-deficient mothers develop iron deficiency anaemia themselves later on in infancy, and this might be due to depleted iron stores at birth (Strauss, 1933). Subsequently, several studies on humans and experimental animals disproved this idea and showed that in iron-deficient pregnant mothers total fetal iron was not reduced, though proportionately more of the fetal iron came from maternal iron absorption than from maternal iron stores (Fullerton, 1937;Sturgeon, 1959;Lanzkowsky, 1961;Beischer et al, 1970;Murray and Stein, 1971). These previous studies comparing iron status of pregnant mothers and their newborn babies were based on the standard tests of serum iron, TIBC, and percentage saturation.…”

Section: Discussionmentioning

confidence: 99%

Relation of maternal and cord blood serum ferritin.

Hussain¹,

Gaafar²,

Laulicht³

et al. 1977

Archives of Disease in Childhood

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SUMMARY Serum ferritin was measured in 51 term normal pregnant mothers and the corresponding cord blood samples. All of the mothers had received prophylactic oral iron and folate during pregnancy. The mean (ISD) maternal serum ferritin at the end of pregnancywas 584±429 ,ug/l (range ,ug/l), compared to a mean of 183 *2±61 *2 ,ug/l (range 62-313 ,ug/l) in these newborns.No correlation was found between the serum ferritin of mothers and babies, nor between the serum ferritin and serum iron of mothers at the end of pregnancy or between these parameters in the newborn.The iron content of the newborn infant is an important source of iron for haemoglobin formation in the first few months of life since the iron content of milk is low. Until recently it has been difficult to assess the influence of maternal iron stores on the iron status of the newborn infant. The introduction of the serum ferritin assay (Addison et al., 1972) has provided a simple, sensitive guide of body iron stores. The purpose of the present study was to determine the relation of serum ferritin of mothers at the time of delivery, and the corresponding cord blood. Patients and methodsFifty-one pregnant women (age range 17-38 years; each had 1-6 pregnancies) attending the Obstetric Clinic at Hull Maternity Hospital contributed in this study. All of them had a term normal pregnancy and normal delivery. Their babies were all term and of normal weight. All of the mothers had received one tablet of Ferrograd-folic per day (ferrous sulphate BP 325 mg and 350 ,ug folic acid BP) since early pregnancy.When the mothers were admitted for delivery, blood samples were obtained from them for determination of Hb, serum iron, total iron binding capacity (TIBC), and serum ferritin. Similar tests were done on cord blood samples.The method used for serum iron and TIBC was that recommended by the International Committee for Standardization in Hematology (1971). Normal range for serum iron is 75-130 ,ug/100 ml (13-4-23-3 ,umol/l), and for TIBC 270-390 Vg/100 ml

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“…The substantially-reduced hepatic stores in the riboflavin-deficient animals rel ative to those in the weight-matched and the rapidly growing ad libitum groups suggest that whereas absorbed iron and reutilizable iron may have satisfied the demands of erythropoiesis in these rats there was little surplus for storage. Human studies indicate that maternal iron deficiency, unless severe, does not compromise the iron status of the newborn [8,13]. Riboflavin deficiency dur ing pregnancy on the other hand has been associated with deficiency of riboflavin in the suckling neonate [2,11], It is possible that, if riboflavin deficiency persists in the neonate it may interfere with the process of hepatic iron accumulation.…”

Section: Discussionmentioning

confidence: 99%

Experiment to Determine the Effect of Riboflavin Deficiency at Weaning on Iron Economy and Heme Synthesis

Powers¹

1985

Ann Nutr Metab

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21 -day-old female Norwegian Hooded rats were fed a riboflavin-deficient diet for 7 weeks. A control group consisted of individually weight-matched rats fed a complete diet. Reticulocytosis was induced by phlebotomy and heme synthesis measured in a reticulocyte-rich preparation in vitro. Concentrations of circulating iron and liver stores of ferritin iron and non-heme iron were measured. Riboflavin deficiency significantly impaired the process of accumulation and maintenance of hepatic iron stores but did not appear to influence the rate of heme synthesis in an in vitro system. A primary lesion in iron metabolism in young fiboflavin-deficient rats may be at the level of iron absorption so that assimilated iron is diverted to the erythroid marrow at the expense of repleting iron stores.

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The Influence of Maternal Iron-deficiency Anaemia on the Haemoglobin of the Infant

Cited by 36 publications

References 23 publications

Observations on Maternal and Fetal Ferritin Concentrations at Term

Observations on Maternal and Fetal Ferritin Concentrations at Term

Relation of maternal and cord blood serum ferritin.

Experiment to Determine the Effect of Riboflavin Deficiency at Weaning on Iron Economy and Heme Synthesis

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