The influence of marine oil intake upon levels of lipids, .ALPHA.-tocopherol and lipid peroxidation in serum and liver of rats.

Mouri, Kayo; Ikesu, Hiromi; Esaka, Tomomi; Igarashi, Osamu

doi:10.3177/jnsv.30.307

Cited by 62 publications

(18 citation statements)

References 16 publications

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“…Peroxidation of lipids is associated with oxygen toxicity and causes degeneration of cell membranes and other lipid-containing structures, and thus is closely associated with pathologies. 5) We have shown in previous studies that the ingestion of DHA, [6][7][8][9][10] as with the ingestion of fish oil, [11][12][13][14] enhanced the susceptibility of rat liver and kidney to lipid peroxidation and increased the requirement for vitamin E (VE). This enhanced lipid peroxidation was a function of the dietary DHA level and was thought to be attributable to the replacement of membrane fatty acids with highly unsaturated DHA.…”

Section: -4)mentioning

confidence: 99%

Induction of Multidrug Resistance-Associated Protein MRP3 in the Liver of Rats Fed with Docosahexaenoic Acid

Kubo

Sekine²,

Saito³

2006

Bioscience, Biotechnology, and Biochemistry

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Section: -4)mentioning

confidence: 99%

Induction of Multidrug Resistance-Associated Protein MRP3 in the Liver of Rats Fed with Docosahexaenoic Acid

Kubo

Sekine²,

Saito³

2006

Bioscience, Biotechnology, and Biochemistry

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“…Lipid peroxidation is a destructive process that can alter membrane function and stability. Increased amounts of dietary polyunsaturated fatty acids thus increase the requirement for VE for prevention of lipid peroxidation [13][14][15][16][17][18][19][20]. Accordingly, the determination of plasma lipid peroxide level as well as the RBC hemolysis test [21][22][23] is also considered to be useful for the assessment of VE nutritional status.…”

mentioning

confidence: 99%

Comparison of Vitamin E Levels in Human Plasma, Red Blood Cells, and Platelets Following Varying Intakes of Vitamin E.

Saito¹,

Nakatsugawa

Oh-hashi³

et al. 1992

J. Clin. Biochem. Nutr.

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SummaryPlasma, red blood cells (RBC), and platelets from young female subjects on varying intakes of vitamin E (YE) as butter or margarine (rich in YE) were analyzed for tocopherols to estimate which blood components most closely followed changes in the dietary intake. The vE nutritional status of the subjects at the beginning of the study was marginally deficient from the normal range of RBC cr-tocopherol. No significant changes in the plasma a-tocopherol concentrations were observed, even though the vE intake had increased. The a-tocopherol level in RBC, however, increased with an increase in vE intake; and that in platelets, to a lesser extent. The plasma lipid peroxide levels were lowered with increased vE intake, showing an inverse change to the cr-tocopherol levels in red blood cells and platelets. Consequently, changes in a-tocopherol levels in RBC closely followed varying dietary intakes of vE when compared with data from platelets and plasma.

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“…In previous studies, we showed that DHA ingestion [7][8][9][10][11], similar to fish oil ingestion [12][13][14][15], enhanced the susceptibility of rat liver and kidney to lipid peroxidation and increased the requirement for vitamin E (Vit. E).…”

Section: Introductionmentioning

confidence: 99%

Docosahexaenoic Acid-Induced Lipid Peroxidation and Urinary Excretion of Mercapturic Acid in Rats

Sekine¹,

Kubo²,

Tadokoro³

et al. 2006

J. Clin. Biochem. Nutr.

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Summary We hypothesized a suppressive mechanism for dietary docosahexaenoic acid (DHA)-induced tissue lipid peroxidation in which the degradation products, especially aldehydic compounds, are conjugated with glutathione (GSH) through catalysis by glutathione S-transferases (GSTs), and then excreted into urine as mercapturic acids. Sprague-Dawley rats were fed a diet containing DHA (8.4 % of total energy) for 31 days. Lipid peroxides in the liver and kidney, liver GST and urinary excretion of mercapturic acid were measured. The lipid peroxide levels in the liver and kidney except the liver aldehydic compounds were higher, and the urinary excretion of mercapturic acid also tended to be higher in the DHA-fed rats although the activity of GST was not increased after DHA intake. We presume from our results that a proportion of the lipid peroxidation-derived aldehydic degradation products might be excreted into urine as mercapturic acid after intake of DHA, thus suppressing the accumulation of aldehydic products in tissues, particularly in the liver.

show abstract

The influence of marine oil intake upon levels of lipids, .ALPHA.-tocopherol and lipid peroxidation in serum and liver of rats.

Cited by 62 publications

References 16 publications

Induction of Multidrug Resistance-Associated Protein MRP3 in the Liver of Rats Fed with Docosahexaenoic Acid

Induction of Multidrug Resistance-Associated Protein MRP3 in the Liver of Rats Fed with Docosahexaenoic Acid

Comparison of Vitamin E Levels in Human Plasma, Red Blood Cells, and Platelets Following Varying Intakes of Vitamin E.

Docosahexaenoic Acid-Induced Lipid Peroxidation and Urinary Excretion of Mercapturic Acid in Rats

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