The influence of low-level laser on orthodontic relapse in rats

Franzen, Tanya Jeanette; Zahra, Sherif Essam; Elkadi, Abbadi; Vandevska‐Radunovic, Vaska

doi:10.1093/ejo/cju053

Cited by 25 publications

(23 citation statements)

References 34 publications

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“…Long-term stability of OTM needs the coordination of appropriate tissue remodeling, growth development, good treatment result, and a suitable retention protocol. 22 The essence of OTM is a process in which malposed teeth move to the normal but not stable position, and the promotion of restoration of normal periodontal tissue is essential to stabilize the teeth in the alveolar cavity. This investigation therefore examined the effects of IP on the relapse potential after OTM, with particular attention to proliferation, osteogenic differentiation, and GPR30-induced signaling pathway of hPDLCs.…”

Section: Discussionmentioning

confidence: 99%

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway

Han¹,

Wang²,

Ma³

et al. 2018

DDDT

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ObjectivesThis study was performed to investigate the effects and mechanism of ipriflavone (IP) on the proliferation and osteoblastic differentiation of periodontal ligament cells in vitro and periodontal tissue remodeling following orthodontic tooth movement (OTM) in vivo.Materials and methodsHuman periodontal ligament cells (hPDLCs) were cultured in vitro and cell counting kit-8, alkaline phosphatase (ALP) activity assay, plate clone formation assay, and alizarin red staining were used to test proliferation and osteogenic differentiation of hPDLCs. What is more, the expression of ALP, Runx2, and GPR30 was examined by real-time polymerase chain reaction and Western blot. To find out if PI3K/AKT signaling pathway was involved in the process, AKT and p-AKT were examined by Western blot. LY294002 (PI3K signaling pathway inhibitor) and small interfering RNA targeting GPR30 mRNA (siGPR30) were used to verify the function of GPR30-mediated PI3K/AKT pathway in this process. Twenty-four male Wistar rats were randomized into 2 groups, the control group with force application and the IP group with force application plus IP. Morphological changes in the periodontal tissue between roots of teeth were investigated using hematoxylin and eosin (HE) staining and bone morphogenetic protein-2 was detected to assess bone remodeling by immunohistochemical staining.ResultsIn vitro, 10−7 M IP was selected significantly promoting proliferation, ALP activity, colony forming efficiency, and mineral deposition (P<0.05) on hPDLCs. Gene expressions of ALP, Runx2, GPR30, and p-AKT were all upregulated than the control group (P<0.05). According to the mechanism, promotion of ALP and Runx2 interdicted by LY294002 and siGPR30 reduced the activation of PI3K/AKT signaling pathway. In addition, HE staining and immunohistochemical staining results showed that the IP group had more new bone formation in the periodontal tissue compared to the control group in vivo.ConclusionIP can promote the expression of ALP and Runx2 which was probably related to the GPR30-mediated PI3K/AKT signaling pathway. Moreover, IP coordination seemed to have the potential to prevent relapsing following OTM.

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Section: Discussionmentioning

confidence: 99%

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway

Han¹,

Wang²,

Ma³

et al. 2018

DDDT

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“…(24,25) Two studies of LLLT (continuous wave GaAlAs at 808nm at 0.71J/cm² and 4.98 J/cm² respectively) significantly increases the remodeling and the turnover rate of the connective tissues surrounding the root during tooth movement in rats. (21,26) These results indicate that LLLT application at the range of 830 nm wavelength is an effective modality in stimulating the remodeling activity and the regenerative capability of the connective tissues around the dental root. (27) Similar results were concluded with light-emitting diode-mediated-photobiomodulation therapy (LPT), on the rate of orthodontic tooth movement (TM) and orthodontically induced root resorption, in rats.…”

Section: A Resorption Inhibiting Agentmentioning

confidence: 86%

An extensive review of literature: considering bone reaction to different agents in orthodontically induced root and alveolar resorption

2017

IJODR

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Objective: Orthodontically induced root resorption is a common problem in day to day practice. If such root resorption could be prevented, it would be an important contribution toward reducing risk factors in orthodontic treatment. The aim of the review is to focus on different agents which can be therapeutically useful in orthodontic tooth movement. Methods and Materials: The article reviews various agents inhibiting as well as promoting root and alveolar bone resorption to orthodontic tooth movement based on advanced PubMed Central (PMC), Cochrane database, Wiley online search of the English language literature from the year 1951 to present in order to help us select the most suitable among them fulfilling the desired criteria of being safe, having less adverse effects, minimal contraindications, rare cross reactions, economically viable, having a scope to be used for successful prognosis and possibly not requiring any special considerations to interpret the results. Results: Forty-nine articles were included in the review, but their interpretation was hindered by the variability in experimental design, magnitude of force applied during tooth movement, and medication regimens. Corticosteroid hormones, parathyroid hormone, and thyroxin have all been shown to increase tooth movement. Bisphosphonates had a strong inhibitory effect. Conclusion: By this review, we conclude that low laser therapy and arginylglycylaspartic acid (RGD) peptide emerges as the clear winner and can result in better prognosis in orthodontic treatment. These techniques are new and cannot replace the conventional agents as a whole.

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“…16 On the other hand, many studies supported the accelerating effects of LLLT on bone resorptive and bone formative activities by the simultaneous activation of all the periodontal cells. [18][19][20] Nevertheless, the present study is valuable in elucidating early PDL tissue response, which is considered to be more critical for immediate relapse than subsequent bone remodeling. …”

Section: Discussionmentioning

confidence: 98%

Combined effect of photobiomodulation with a matrix metalloproteinase inhibitor on the rate of relapse in rats

Lee

Kim

Anderson

et al. 2015

The Angle Orthodontist

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Objective: To investigate combined effect of photobiomodulation with a matrix metalloproteinase (MMP) inhibitor on the relapse rate in relation to MMP expression in rats. Materials and Methods: Fifty-two rats were divided into four groups according to the treatment modality: control group, irradiation group, doxycycline group, and irradiation with doxycycline group. During a relapse period of 5 days after orthodontic movement, maxillary central incisors were treated by low-level laser therapy (LLLT) as a photobiomodulation and/or doxycycline as a synthetic MMP inhibitor. Relapse rate was evaluated in association with MMP expression at the gene and protein levels. Results: Relapse rates were increased by LLLT (1.57-fold) and decreased by doxycycline (0.83-fold) compared with the control, showing positive correlation with the levels of expression for all MMPs in the periodontal ligament (PDL). LLLT concomitant with doxycycline administration resulted in no significant differences of relapse rate and MMP expression from the control. Conclusions: The combined effect of photobiomodulation with an MMP inhibitor around the relapsing teeth proved to be antagonistic to PDL remodeling activity during relapse. This study suggests a basis for developing a novel biologic procedure targeting the MMP-dependent PDL remodeling to control the relapse rate. (Angle Orthod. 2016;86:206-213.)

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The influence of low-level laser on orthodontic relapse in rats

Abstract: These results indicate that LLLT may reduce the relapse tendency, possibly due in part to bone formation in previous tension areas, and to redistribution of osteoclasts following removal of orthodontic force. The role of LLLT in the prevention of orthodontic relapse requires further study.

Cited by 25 publications

References 34 publications

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway

An extensive review of literature: considering bone reaction to different agents in orthodontically induced root and alveolar resorption

Combined effect of photobiomodulation with a matrix metalloproteinase inhibitor on the rate of relapse in rats

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