The influence of local administration of simvastatin in calvarial bone healing in rats

Calixto, Jimmy Cavalcanti; Lima, Carlos Eugênio Villaboim de Castro; Frederico, L; Lima, Rafaela Pio dos Santos de Castro; Anbinder, Ana Lia

doi:10.1016/j.jcms.2010.03.009

Cited by 34 publications

(26 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Collagen sponges were used in 2 out of these 3 studies [17,20] yet, they were of different origin and the simvastatin dose used in both studies was also different. In the third study gelatin sponge was used as a carrier for simvastatin.…”

Section: Results:-mentioning

confidence: 99%

“…The second study that used collagen sponge was performed by Calixto et al in 2011 [17] in which it was of swine origin due to the outbreak of bovine spongiform at this time. A bilateral critical sized bone defects were created in the parietal bones of 64 Wistar rats using a 5-mm diameter trephine.…”

Section: Results:-mentioning

confidence: 99%

“…[14,15] However, on addressing the anti-inflammatory effect of simvastatin, it should be kept in mind that, simvastatin in high doses can actually induce inflammation around the site of local application, [16] that is to say, while a low dose can be inefficient in bone formation, high doses may stimulate an excessive inflammatory response [17] which is well recognized as a major contributing factor to delay healing in both animal and human models. [18,19] The effect of locally applied simvastatin on bone formation received the main attention of researchers in the last few years as it was used in combination with various carriers such as collagen sponge, [17,20] Alpha tricalcium phosphate (α-TCP), [12,21]Beta tricalcium phosphate(β-TCP), [21]hydroxyapatite (HA), [21] gelatin sponge [22]and bioglass. [23] The results of these studies showed that the local effect of Simvastatin on bone depends on 2 main factors which are the used carrier and the simvastatin dose.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

See 2 more Smart Citations

Simvastatin as a Sole Osteopromotive Material in Critically Sized Bone Defects: Systematic Review.

Gouda¹,

Helal²,

Bakry³

et al. 2017

IJAR

View full text Add to dashboard Cite

Section: Results:-mentioning

confidence: 99%

Section: Results:-mentioning

confidence: 99%

Section: Issn: 2320-5407mentioning

confidence: 99%

See 1 more Smart Citation

Simvastatin as a Sole Osteopromotive Material in Critically Sized Bone Defects: Systematic Review.

Gouda¹,

Helal²,

Bakry³

et al. 2017

IJAR

View full text Add to dashboard Cite

“…Impregnation of bone scaffolds with Simvastatin is the simplest way, but because the drug has high delivery rate (burst release effect) in the injured area, most of the drug is dissolved in the blood circulation and removed from the body so that the bioavailability of the drug is too short to be effective in influencing the reparative and remodelling phase of bone healing. 58,60 Alternatively, Simvastatin can be coated on the bone scaffolds by various methods such as spray techniques and ultrasonic dispersion. 1,113 However, in this method only low concentrations of Simvastatin can be coated and thus, the drug availability is more valuable in the inflammatory phase of bone healing and cannot be increased in order to influence later stages (e.g.…”

Section: Drug Delivery Systems Used In Simvastatin Therapymentioning

confidence: 99%

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

Moshiri

Sharifi

Oryan

2016

Clin Exp Pharma Physio

View full text Add to dashboard Cite

SUMMARYSimvastatin is a lipid lowering drug whose beneficial role on bone metabolism was discovered in 1999. Several in vivo studies evaluated its role on osteoporosis and fracture healing, however, controversial results are seen in the literature. For this reason, Simvastatin has not been the focus of any clinical trials as yet. This systematic review clears the mechanisms of action of Simvastatin on bone metabolism and focuses on in vivo investigations that have evaluated its role on osteoporosis and fracture repair to find out (i) whether Simvastatin is effective on treatment of osteoporosis and fracture repair, and (ii) which of the many available protocols may have the ability to be translated in the clinical setting. Simvastatin induces osteoinduction by increasing osteoblast activity and differentiation and inhibiting their apoptosis. It also reduces osteoclastogenesis by decreasing both the number and activity of osteoclasts and their differentiation. Controversial results between the in vivo studies are mostly due to the differences in the route of administration, dose, dosage and carrier type. Local delivery of Simvastatin through controlled drug delivery systems with much lower doses and dosages than the systemic route seems to be the most valuable option in fracture healing. However, systemic delivery of Simvastatin with much higher doses and dosages than the clinical ones seems to be effective in managing osteoporosis. Simvastatin, in a particular range of doses and dosages, may be beneficial in managing osteoporosis and fracture injuries. This review showed that Simvastatin is effective in the treatment of osteoporosis and fracture healing.

show abstract

“…Simvastatin has been shown to enhance osseointegration of pure titanium implants in osteoporotic rats. (11) Other experimental study shows that locally administered simvastatin was detrimental to the repair of defects in the calvaria of rats (12) . The period required generally for an osseointegration to be achieved and for dental implant to be loaded is about 3-6 months which still represent a relatively long period for patients and any efforts focusing on reducing this period are entitled for consideration and scientific research which is the objective of this study.…”

Section: Introductionmentioning

confidence: 99%

Effect of Systemic Administration of Simvastatin on Dental Implant Stability: A Random Clinical Study

Mohammed¹,

Kayat²

2016

Iraqi dent. j.

View full text Add to dashboard Cite

Background: the primary objective for many researches carried out in dental implantology was to reduce the period needed for functional implant loading, simvastatin (cholesterol lowering medication) had many pleiotropic effects, one of which was increasing bone density around titanium implants (1) and subsequently establishing faster osseointegrated dental implants (2,3) . Aim of the study: this study aims to reduce the period of time needed to establish secondary stability of dental implant measured in ISQ (Implant Stability Quotient) by investigating the effect of orally administered simvastatin on bone. Materials and methods: simvastatin tablets (40mg/day for three months) were administered orally for 11 healthy women aged (40-51) years old who received 15 dental implants (Dentium, Implantium) in the traumatic functional implant zone (4) , this is the intervention group, the control group (n=11) received 14 dental implants in the same zone. 3 dental implants in 2 subjects were lost, leaving a total of 26 dental implants in 20 patients with 10 patients in each group. All subjects were radiographed with OPG for preliminary assessment and with CT scan for registering bone density in Hounsfield Units. Different dental implant sizes were used according to optimal patients' needs. an informed consent was obtained from the intervention group and the recommended monitoring protocol was followed. Dental implant stability ISQ were recorded using RFA by Osstell TM ISQ for both groups three times: immediately after implant placement (at surgery) and after 8,12 weeks respectively. Results: results showed that the mean implant stability for the intervention group was significantly higher P= 0.01 after 12 weeks in comparison to that of the control group. Simvastatin showed statistically significant effect on implant stability among the intervention group after 8 and 12 weeks (P value for both times <0.001) with the attributed risk percent was 70.8 and 50 respectively. Conclusions: this study concluded that the intervention group had higher implant stability and was ready for functional loading prior to control group and that simvastatin might enhanced and/or accelerated the process of osseointegration.

show abstract

The influence of local administration of simvastatin in calvarial bone healing in rats

Cited by 34 publications

References 32 publications

Simvastatin as a Sole Osteopromotive Material in Critically Sized Bone Defects: Systematic Review.

Simvastatin as a Sole Osteopromotive Material in Critically Sized Bone Defects: Systematic Review.

Role of Simvastatin on fracture healing and osteoporosis: a systematic review onin vivoinvestigations

Effect of Systemic Administration of Simvastatin on Dental Implant Stability: A Random Clinical Study

Contact Info

Product

Resources

About