Jimmy Cavalcanti Calixto, Carlos Eugênio Villaboim de Castro Lima, Lilian Frederico, Rafaela Pio dos Santos de Castro Lima, Ana Lia Anbinder
Abstract:Some authors have associated the use of statins, hypolipidemic drugs, and new bone formation. The aim of this work was to evaluate the effect of locally administered simvastatin on bone healing. Bone calvarial defects 5mm in diameter were made in 64 rats. The animals were divided into four groups according to the graft material: the control group, in which the defects were not treated, the SIM-1 group, which received a sponge of collagen soaked with simvastatin (2.2 mg/50 μl), the SIM-2 group, which received a…
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