The influence of laser parameter configurations at 9.3 μm on incisional and collateral effects in soft tissue

Histologic evaluation of thermal damage produced on soft tissues by CO2, Er,Cr:YSGG and diode lasers

“…Moreover, the epithelial thickness of the pig mucosa is higher than in rabbit mucosa, attributing to a smaller size of hyalized area found in pig sample. To reproduce the body temperature, the specimen can be previously stored in an aqueous fluid at body temperature (16), but one of the most used study models, which was employed in our investigation, does not consider this variable (11). In the present investigation, the results of the diode laser group were similar to those reported by Goharkhay et al (4) in their in vitro study on soft tissues of a pig jaw.…”

“…The literature describes different methodologies to measure it, such as measurement of temperature increase on the tissue (5,8), energy absorption by the target tissue (9,10) and the most common, the histological evaluation of the tissue next to the irradiated area (4,11,12). Most reports point out that the result of this temperature increase can be inferred from denaturalization and hyalinization of the tissue next to the irradiated area, and it can be assessed using conventional techniques of microscopy and standard staining of hematoxillin-eosin, which show an area of eosinophilic coagulation (1,12,13).…”

Comparison of lateral thermal injury and healing of porcine skin incisions performed by CO2‐laser, monopolar electrosurgery and radiosurgery: a preliminary study based on histological and immunohistochemical results

“…The investigated animal model is common in studies of this sort, due to the similarity of structural and healing characteristics between porcine and human skin. However, animal studies should only be considered a useful indicator rather than a directly transferable predictor of potential effects of various surgical instruments in humans 11,31,32 …”

Relationship between CO2 laser–induced artifact and glottic cancer surgical margins at variable power doses

“…However, in terms of objective voice comparisons, irradiated patients scored higher. Postoperative discomfort is also reported to be less when laser surgical methods are used …”

“…Postoperative discomfort is also reported to be less when laser surgical methods are used. 11 In order to achieve local disease control and therefore ultimate cure, complete oncologic excision of the early glottic carcinoma with an adequate margin is paramount. It is well-established that patients with close or involved surgical margins have significantly higher rates of locoregional recurrence and potentially decreased survival.…”