The Influence of Lactobacillus paracasei HII01 Supplementation on Performance in Attention (Go/No-Go) Tasks and Quinolinic Acid and 5-Hydroxyindoleacetic Acid Levels in Thai Children—A Preliminary Study

Abstract

Cognitive development is defined as the capacity of a child to think, reason, and use language, which are all vital to their overall growth. Attention deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder. Though several factors are associated with the incidence of ADHD, gut microbiota and gut homeostasis play critical roles in it. Gut dysbiosis and altered gut homeostasis are linked to several physical and psychological complications that affect gut–brain communication (the gut–brain axis). Probiotics, live microorganisms that confer a health benefit to the host when administered in adequate amounts, are considered therapeutic supplements that can be used to manage mental and cognitive disorders. Intervention with probiotics can improve the gut microbial ecosystem and the gut–brain axis, thereby improving cognitive function. We hypothesized that the supplementation of Lactobacillus paracasei HII01 might reduce the risk of the development of neuropsychiatric disorders; thus, we evaluated the efficacy of L. paracasei HII01 on the attention state of healthy children and the changes in representative neuroinflammatory markers. Ten healthy Thai children were supplemented with 109 CFU of L. paracasei HII01 for 12 weeks. Go/no-go tasks were undertaken to assess changes in attention state. Alterations in brain waves were measured by electroencephalographic (EEG)/event-related potential (ERP) recordings. The levels of quinolinic acid (QA, a metabolite of tryptophan) and 5-hydroxyindoleacetic acid (5-HIAA, a metabolite of serotonin) were determined in the urine at baseline and after 12 weeks of probiotic intervention. The levels of QA and 5-HIAA significantly decreased and increased, respectively. The QA/5-HIAA ratio also decreased significantly. Go/No-go tasks revealed that the percentages of go accuracy and go error increased and decreased significantly, respectively. EEG/ERP recordings showed that theta, alpha, and beta waves were substantially altered at the 12th week of study compared to baseline values. The results suggested that L. paracasei HII01 might improve the gut microbiota and oscillate the brain function, which sustained the attention state of the subjects. These preliminary findings require further detailed study to confirm the role of L. paracasei HII01 in the improvement in the attention of healthy children.

Ingestion of Lacticaseibacillus rhamnosus Fmb14 prevents depression-like behavior and brain neural activity via the microbiota–gut–brain axis in colitis mice

“…A preliminary study on the cognition of children in Thailand found that Lactobacillus paracasei HII01 increased the levels of HIAA in urine after 12 weeks of supplementation and the attention state of children significantly improved. 62 Additionally, the decreased levels of ZO-1 and Ocln indicated that DSS exposure caused the tight junctions of the brain to disappear, which indicated the disordered permeability of the blood–brain barrier, 63 and the ZO-1 levels were restored to those of the control group in the Fmb14 group. Alterations in the blood–brain barrier lead to the loss of protection against exposure of the brain to molecules and bacterial metabolites in blood, which may cause damage to astrocytes or pericytes in the brain.…”

Normative cognition and the effects of a probiotic food intervention in first grade children in Côte d’Ivoire

“…Most important, consistent and prolonged administration will be necessary to draw strong conclusions about probiotic effects on cognitive outcomes. Indeed, such studies are warranted given recent evidence pointing to probiotic effects on attention tasks in Thai children (6-12-year-olds) after prolonged (12 weeks) administration 49 . Moreover, multiple reviews published since this study was conducted have found evidence for a potential role of probiotics and prebiotics in improved cognitive function in humans [50][51][52] .…”

Nutritional considerations in major depressive disorder: current evidence and functional testing for clinical practice

“…Specific nutritional factors have been shown to influence quinolinic acid levels and reduce quinolinic induced damage. These include probiotics (65) , polyphenols (66) and essential fatty acids (67) . Assessing intake of these dietary components may therefore be valuable.…”