The Influence of L‐tryptophan and Monoamine Oxidase Inhibitors on Catecholamine Metabolism in Rat Brain

Eccleston, D.; Nicolaou, Nicos

doi:10.1111/j.1476-5381.1978.tb08655.x

Cited by 20 publications

(2 citation statements)

References 18 publications

(24 reference statements)

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“…Suppression of ejaculation was also associated with increase in the dopamine content of the lower lumbar segments. This might be explained as a consequence of dopamine release caused by the increase in serotonin, as reported by Eccleston and Nicolaou (1978). It is recognized that spinal contents of noradrenaline and serotonin are varied with different animal species.…”

Section: Discussionmentioning

confidence: 80%

The Spinal Monoaminergic Systems Relating to Ejaculation

et al. 2009

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In the previous paper (Kimura et al. -1982) the authors reported on the distribution on noradrenaline, dopamine, serotonin and 5-hydroxyindole acetic acid in the spinal cord and recognized that changes of monoamine levels occurred in the spinal cord by administration of various psychotropic drugs and that the spinal catecholamines might have direct functional significance in ejaculation.In the present study the effect on ejaculation of administration of 5-hydroxytryptophan (5-HTP), the direct precursor of serotonin with pretreatment with Ro 44602, a peripheral decarboxylase inhibitor, was investigated in an attempt to elucidate the role of the spinal serotonergic system in ejaculation. Materials and MethodsAnimals: Twenty-seven male adult mongrel dogs weighing 10-1 5 Kg were used for the study. The dogs were selected 3 days prior to the start of administration for the following drugs and those showing both normal erection and ejaculation by manual stimulation of the penis were admitted to the study. Dncgs: The drugs used in the present study were Ro 4-4602 (Japan Roche) and L-5hydroxytryptophan (L-5HTP) (Kyowa Hakko Co.). Ro 4-4602 was administered as a solution in saline and L-5HTP as a suspension in 0.5% tween 80. These drugs were administered intraperitoneally. Procedure: Penile erection and ejaculation were induced in these animals by manual stimulation of the penis as described in the previous papers (Kimura et al. -1976(Kimura et al. - ,1977(Kimura et al. - and 1982. The contents of noradrenaline, dopamine, serotonin and 5-hydroxyindole acetic acid were determined by the method reported previously (Kimura et al. -1976 and. Results Effect ofRo 4-4602 plus L-SHTP on ejaculation:Adult dogs with normal erection and ejaculation were administered 12.5,25 or 50 rng/Kg of L-5HTP with pretreatment with 20 mg/Kg of Ro 44602. One hour after the administration ejaculation was suppressed in 6 of 8 dogs receiving 12.5 mg/Kg, in all dogs given 25 mg/Kg and in 10 of 11 dogs given 50 mg/Kg of L-5 HTP. Penile erection was maintained in most of dogs so treated ( Table 1). Changes in noradrenaline (NA), dopamine (DA), serotonin (5-HT) and 5-hydroxyindoleKey words: Ejaculationspinal monoaminesserotonindopaminenoradrenaline -S-hydroxyindole acetic acid andrologia 15 (1983)

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Section: Discussionmentioning

confidence: 80%

The Spinal Monoaminergic Systems Relating to Ejaculation

et al. 2009

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“…It has been suggested that the increase in brain 5-hydroxytryptamine (5-HT) which this treatment causes in animals (Ashcroft, Eccleston & Crawford, 1965) might be the therapeutic agent. In a recent paper, Eccleston & Nicolaou (1978) showed that although 5-HT levels do rise after such treatment, the rise is associated with an increase of concentrations of CA metabolites, suggesting that the release of CA is another possible therapeutic effect. Such a mechanism was actually proposed by one of the earliest clinical investigations of the efficacy of combined tryptophan and MAOI (Pare.…”

Section: Introductionmentioning

confidence: 99%

Uptake of 5‐hydroxytryptamine in the Catecholamine Containing Areas of the Hypothalamus of the Rat After Treatment With Phenelzine and Tryptophan

Arbuthnott

Eccleston

László

et al. 1981

British J Pharmacology

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Alterations in stress‐induced responses in the rat produced by amino acids

Quirce¹,

Vargas²,

Coto³

et al. 1985

Stress Med.

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The effects of repetitive exposure of rats to immobilization stress were examined in terms of alterations in body weight gain, adrenal size and plasma levels of corticosterone, fatty acids and glucose. Prestress administrations of small doses of L‐alanine, L‐tryptophan and L‐tyrosine were tested for ability to modulate the stress‐induced effects. In general, L‐alanine had no characteristic actions, L‐tryptophan exacerbated and L‐tyrosine modulated the stress effects.

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The Influence of L‐tryptophan and Monoamine Oxidase Inhibitors on Catecholamine Metabolism in Rat Brain

Cited by 20 publications

References 18 publications

The Spinal Monoaminergic Systems Relating to Ejaculation

The Spinal Monoaminergic Systems Relating to Ejaculation

Uptake of 5‐hydroxytryptamine in the Catecholamine Containing Areas of the Hypothalamus of the Rat After Treatment With Phenelzine and Tryptophan

Alterations in stress‐induced responses in the rat produced by amino acids

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